{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:06:12Z","timestamp":1787846772413,"version":"build-2784847793"},"reference-count":46,"publisher":"Aboutscience Srl","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch. Physioter"],"abstract":"<jats:p>Introduction:\u00a0Gait impairments are common in People with Multiple Sclerosis (PwMS). Several studies have examined the clinometric properties of Inertial Measurement Units (IMUs), with LDLJa identified as a robust metric for gait smoothness. However, its responsiveness and interpretability have not been explored.\nMethods:\u00a0This cross-sectional study at IRCCS Santa Lucia Hospital enrolled 44 PwMS (age: 28-71; EDSS: 0-6) and 43 age- and gait-speed-matched healthy participants (HP). Two physiotherapists conducted assessments with five synchronized IMUs during a 10-meter walk at participants\u2019 preferred speed. Data were collected at baseline (T0) and after 4 weeks of training (T1).\nResults:\u00a0Significant differences in log dimensionless jerk (LDLJa) were found between PwMS and HP in the AP (p &lt; 0.001, d = 0.63), ML (p &lt; 0.001, d = 1.08), and CC (p = 0.03, d = 0.68) directions. PwMS had lower LDLJaAP values (&lt; -4.88) and LDLJaML values (&lt; -5.40) with probabilities of 63% and 76%, respectively. \u0394LDLJaML demonstrated good responsiveness to rehabilitation (AUC ~0.80), with improvements &gt;4.02% representing the optimal MCID for clinical improvement in MiniBesTest.\nConclusion:\u00a0Lower LDLJa values in the AP and ML directions characterize gait smoothness impairment in PwMS. LDLJa in the ML direction is responsive to balance-focused rehabilitation, highlighting its potential for tracking gait disorders and rehabilitation progress.<\/jats:p>","DOI":"10.33393\/aop.2025.3289","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T03:15:28Z","timestamp":1738638928000},"page":"9-18","source":"Crossref","is-referenced-by-count":7,"title":["Discriminative ability, responsiveness, and interpretability of smoothness index of gait in people with multiple sclerosis"],"prefix":"10.33393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5329-5197","authenticated-orcid":false,"given":"Stefano Filippo","family":"Castiglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-600X","authenticated-orcid":false,"given":"Fulvio","family":"Dal Farra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4739-3441","authenticated-orcid":false,"given":"Dante","family":"Trabassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-8060","authenticated-orcid":false,"given":"Andrea","family":"Turolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3031-680X","authenticated-orcid":false,"given":"Mariano","family":"Serrao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-4441","authenticated-orcid":false,"given":"Ugo","family":"Nocentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2545-3930","authenticated-orcid":false,"given":"Paolo","family":"Brasiliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9055-3981","authenticated-orcid":false,"given":"Elena","family":"Bergamini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6034-0638","authenticated-orcid":false,"given":"Marco","family":"Tramontano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18642","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"15043","doi-asserted-by":"crossref","unstructured":"Comber L, Galvin R, Coote S. 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