{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:10:36Z","timestamp":1774858236690,"version":"3.50.1"},"reference-count":33,"publisher":"Aboutscience Srl","issue":"1","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch. Physioter"],"abstract":"<jats:p>Introduction: Understanding how people with multiple sclerosis (PwMS) acquire motor skills during rehabilitation is essential for optimizing treatment strategies. Motor learning theory suggests that skill acquisition follows predictable trajectories, but the time course and variability of learning during task-oriented rehabilitation remain poorly defined in PwMS. The aim was toinvestigate the learning trajectory and performance variability in PwMS undergoing task-oriented rehabilitation, using mathematical modeling of behavioral changes over time.Methods: This longitudinal prospective study included 44 PwMS admitted to a rehabilitation unit. Participants received either balance-specific or non-specific motor impairment treatments. Balance performance was assessed with the Berg Balance Scale (BBS) after each session. Session-to-session changes were analyzed using linear and exponential models to characterize the learning pattern, and residuals were examined to quantify variability.Results: An exponential mixed model (Akaike information criterion (AIC) = 2514.1) best described learning trajectories and provided more accurate estimates of pre-to-post improvement compared to a linear model (AIC = 2672.1). Performance variability decreased across sessions, from 1.16 to 0.75 points. Participants receiving specific balance treatment reached the minimalclinically important difference after three sessions, while participants receiving non-specific treatments achieved MCID only after 7 sessions.Conclusions: Motor performance changes in PwMS during rehabilitation resemble motor learning in healthy individuals: improvements follow an exponential function and are accompanied by reduced variability. Treatment specificity enhances the velocity and magnitude of learning, underscoring the importance of targeted interventions in neurorehabilitation.<\/jats:p>","DOI":"10.33393\/aop.2026.3864","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T07:21:32Z","timestamp":1774855292000},"page":"44-50","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the clinical pattern of motor relearning in people with multiple sclerosis"],"prefix":"10.33393","volume":"16","author":[{"given":"Davide","family":"Cattaneo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Gervasoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Meotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8287-4881","authenticated-orcid":false,"given":"Johanna","family":"Jonsdottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18642","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"18267","doi-asserted-by":"crossref","unstructured":"1 Cameron MH, Lord S. 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Mobility and balance rehabilitation in multiple sclerosis: A systematic review and dose-response meta-analysis. Mult Scler Relat Disord. 2023;69:104424. https:\/\/doi.org\/10.1016\/j.msard.2022.104424","DOI":"10.1016\/j.msard.2022.104424"},{"key":"18271","unstructured":"5 Schmidt, Richard A, et al. Motor control and learning: a behavioral emphasis. Human kinetics. 2018."},{"key":"18272","doi-asserted-by":"crossref","unstructured":"6 Anderson RB. The power law as an emergent property. Mem Cognit. 2001;29(7):1061-1068. https:\/\/doi.org\/10.3758\/BF03195767 PMID:11820749","DOI":"10.3758\/BF03195767"},{"key":"18273","doi-asserted-by":"crossref","unstructured":"7 Button C, Lee CYM, Dutt MA, et al. Empirical investigations of nonlinear motor learning. The Open Sports Sciences Journal. 2012;5(Suppl 1-M6):49-58 DOI:10.2174\/1875399X01205010049","DOI":"10.2174\/1875399X01205010049"},{"key":"18274","unstructured":"8 Newell A, Rosenbloom PS. 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