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Licorice extract is derived from dried, unpeeled stolons and roots of\u00a0Glycyrrhiza uralensis\u00a0and\u00a0G. glabra. The bioactive ingredients in licorice extract such as glycyrrhizin, licoricidin, glabridin, licochalcone A, and licorisoflavan A have anti-inflammatory, antimicrobial, and anti-adherence effects that are beneficial against periodontal disease. Since periodontal disease has a complex etiology that includes the host response and microorganisms, licorice phytochemicals offer a therapeutic advantage due to their dual functionality. The aim of this review was to enumerate the bioactive compounds present in herbal licorice extract and to elucidate the beneficial effects of licorice and its derivatives in periodontal therapy. Literature review and clinical trials evaluating the effect of licorice on periodontopathogens and periodontal disease are included in this article.<\/jats:p>","DOI":"10.33393\/dti.2023.2583","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T08:28:54Z","timestamp":1685953734000},"page":"70-77","source":"Crossref","is-referenced-by-count":14,"title":["Licorice as a herbal extract in periodontal therapy"],"prefix":"10.33393","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-128X","authenticated-orcid":false,"given":"Safiya Fatima","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8701-3864","authenticated-orcid":false,"given":"Bhavya","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1618-883X","authenticated-orcid":false,"given":"Ibrahim","family":"Fazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2120-0178","authenticated-orcid":false,"given":"Asim","family":"Mustafa Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheem","family":"Muzaffar Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhamood","family":"Moothedath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1345-1452","authenticated-orcid":false,"given":"Reshma","family":"VJ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3445-2983","authenticated-orcid":false,"given":"Muhaseena","family":"Muhamood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18642","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"9705","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6713.2004.003559.x"},{"key":"9706","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00148.x"},{"key":"9707","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510376402"},{"key":"9708","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2022.01.005"},{"key":"9709","doi-asserted-by":"publisher","DOI":"10.26717\/BJSTR.2019.19.003254"},{"key":"9710","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2017.12.004"},{"key":"9711","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2006.06.002"},{"key":"9712","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01842.x"},{"key":"9713","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6316"},{"key":"9714","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064255"},{"key":"9715","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01023-12"},{"key":"9716","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.04.040"},{"key":"9717","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.08.001"},{"key":"9718","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1661-4"},{"key":"9719","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1350698"},{"key":"9720","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.11.019"},{"key":"9721","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22920"},{"key":"9722","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121382"},{"key":"9723","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.06.016"},{"key":"9724","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1074494"},{"key":"9725","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.03.055"},{"key":"9726","unstructured":"Halder RM, Richards GM. 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