{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T10:26:39Z","timestamp":1747218399931,"version":"3.40.5"},"reference-count":29,"publisher":"Aboutscience Srl","issue":"1","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Grhta"],"abstract":"<jats:p>Background and Objectives:\u00a0The objective of this study is to evaluate the economic impact of the device Navina Smart on patients affected by neurogenic bowel dysfunction and dependent on transanal irrigation within the Italian context. This study employs the perspective of the Italian National Health Service.\nMethods:\u00a0The analysis was conducted through a Markov model, comparing two scenarios: standard bowel care vs. transanal irrigation. The model operates on a 30-year time period. The results were reported in terms of net monetary benefit.\nResults:\u00a0Transanal irrigation therapy was dominant in all scenarios with lower costs and higher effectiveness. The population was assumed to be composed of 1,000 subjects. Setting the willingness to pay at \u20ac35,000.00\/QALYs (quality-adjusted life years), the analysis yielded a net monetary benefit of \u20ac81,087 and cost savings of \u20ac66,101 per patient over 30 years.\nConclusion:\u00a0The results of this study substantiate that transanal irrigation therapy treatment employing the Navina Smart device can significantly benefit patients suffering from neurogenic bowel dysfunction by relieving their symptoms. In addition, this therapy offers important cost savings for the Italian National Health Service by reducing resource utilization.<\/jats:p>","DOI":"10.33393\/grhta.2024.3168","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T13:24:31Z","timestamp":1731936271000},"page":"214-222","source":"Crossref","is-referenced-by-count":0,"title":["A cost-effectiveness analysis of Navina Smart on adult patients affected by neurogenic bowel dysfunction"],"prefix":"10.33393","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-7424","authenticated-orcid":false,"given":"Matteo","family":"Ruggeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9768-3252","authenticated-orcid":false,"given":"Alessandro","family":"Signorini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Caravaggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6655-9518","authenticated-orcid":false,"given":"Gabriele","family":"Righi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18642","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"13799","unstructured":"Bennett J, Das JM, Emmady PD. Spinal cord injuries. StatPearls Treasure Island, Florida: StatPearls Publishing; 2022. PMID: 32809556"},{"key":"13800","unstructured":"Altems, Valutazione HTA del dispositivo medico Peristeen Plus\u00ae. https:\/\/altems.unicatt.it\/altems-research-consultancy-valutazione-hta-del-dispositivo-medico-peristeen-plus. Accessed June 2024."},{"key":"13801","doi-asserted-by":"crossref","unstructured":"Emmanuel A, Kumar G, Christensen P, et al. Long-term cost-effectiveness of transanal irrigation in patients with neurogenic bowel dysfunction. PLoS One. 2016;11(8):e0159394. https:\/\/doi.org\/10.1371\/journal.pone.0159394 PMID:27557052","DOI":"10.1371\/journal.pone.0159394"},{"key":"13802","doi-asserted-by":"crossref","unstructured":"Emmanuel A, Kurze I, Krogh K, et al. An open prospective study on the efficacy of Navina Smart, an electronic system for transanal irrigation, in neurogenic bowel dysfunction. PLoS One. 2021;16(1):e0245453. https:\/\/doi.org\/10.1371\/journal.pone.0245453 PMID:33513187","DOI":"10.1371\/journal.pone.0245453"},{"key":"13803","doi-asserted-by":"crossref","unstructured":"Dale M, Morgan H, Carter K, White J, Carolan-Rees G. Peristeen transanal irrigation system to manage bowel dysfunction: a NICE medical technology guidance. Appl Health Econ Health Policy. 2019;17(1):25-34. https:\/\/doi.org\/10.1007\/s40258-018-0447-x PMID:30426450","DOI":"10.1007\/s40258-018-0447-x"},{"key":"13804","doi-asserted-by":"crossref","unstructured":"Knowles CH, Booth L, Brown SR, et al. Non-drug therapies for the management of chronic constipation in adults: the CapaCiTY research programme including three RCTs. Programme Grants for Applied Research. 2021;9(14):1-134. https:\/\/doi.org\/10.3310\/pgfar09140 PMID:34855315","DOI":"10.3310\/pgfar09140"},{"key":"13805","doi-asserted-by":"crossref","unstructured":"Musco S, Bazzocchi G, Martellucci J, et al. Treatments in neurogenic bowel dysfunctions: evidence reviews and clinical recommendations in adults. Eur J Phys Rehabil Med. 2020;56(6):741-755. PMID:32935955","DOI":"10.23736\/S1973-9087.20.06412-6"},{"key":"13806","doi-asserted-by":"crossref","unstructured":"Sengoku A, Noto S, Nomi M, Emmanuel A, Murata T, Mimura T. Cost-effectiveness analysis of transanal irrigation for managing neurogenic bowel dysfunction in Japan. J Health Econ Outcomes Res. 2018;6(1):37-52. https:\/\/doi.org\/10.36469\/9781 PMID:32685570","DOI":"10.36469\/9781"},{"key":"13807","doi-asserted-by":"crossref","unstructured":"Sakakibara R. Gastrointestinal dysfunction in movement disorders. Neurol Sci. 2021;42(4):1355-1365. https:\/\/doi.org\/10.1007\/s10072-021-05041-4 PMID:33538914","DOI":"10.1007\/s10072-021-05041-4"},{"key":"13808","doi-asserted-by":"crossref","unstructured":"Hultling C. Neurogenic bowel management using transanal irrigation by persons with spinal cord injury. Phys Med Rehabil Clin N Am. 2020;31(3):305-318. https:\/\/doi.org\/10.1016\/j.pmr.2020.04.003 PMID:32624096","DOI":"10.1016\/j.pmr.2020.04.003"},{"key":"13809","doi-asserted-by":"crossref","unstructured":"Emmanuel AV, Krogh K, Bazzocchi G, et al; Members of working group on Trans Anal Irrigation from UK, Denmark, Italy, Germany, France and Netherlands. Consensus review of best practice of transanal irrigation in adults. Spinal Cord. 2013;51(10):732-738. https:\/\/doi.org\/10.1038\/sc.2013.86 PMID:23958927","DOI":"10.1038\/sc.2013.86"},{"key":"13810","unstructured":"National Institute for Health and Care Excellence (NICE). NICE Guidance. Peristeen transanal irrigation system for managing bowel dysfunction. Feb. 23, 2018. https:\/\/www.nice.org.uk\/guidance\/mtg36. (Accessed June 2024)."},{"key":"13811","doi-asserted-by":"crossref","unstructured":"Juul T, Christensen P. Prospective evaluation of transanal irrigation for fecal incontinence and constipation. Tech Coloproctol. 2017;21(5):363-371. https:\/\/doi.org\/10.1007\/s10151-017-1635-7 PMID:28550422","DOI":"10.1007\/s10151-017-1635-7"},{"key":"13812","unstructured":"Wellspect Italia. Navina Medical Internal Documents. Wellspect Italia; 2024."},{"key":"13813","doi-asserted-by":"crossref","unstructured":"Christensen P, Andreasen J, Ehlers L. Cost-effectiveness of transanal irrigation versus conservative bowel management for spinal cord injury patients. Spinal Cord. 2009;47(2):138-143. https:\/\/doi.org\/10.1038\/sc.2008.98 PMID:18679401","DOI":"10.1038\/sc.2008.98"},{"key":"13814","doi-asserted-by":"crossref","unstructured":"Emmanuel A, Collins B, Henderson M, Lewis L, Stackhouse K. Development of a decision guide for transanal irrigation in bowel disorders. Gastrointest Nurs. 2019;17(7):24-30. https:\/\/doi.org\/10.12968\/gasn.2019.17.7.24","DOI":"10.12968\/gasn.2019.17.7.24"},{"key":"13815","doi-asserted-by":"crossref","unstructured":"Bardsley A. Transanal irrigation systems for managing bowel dysfunction: a review. Gastrointest Nurs. 2020;18(5):18-28. https:\/\/doi.org\/10.12968\/gasn.2020.18.5.18","DOI":"10.12968\/gasn.2020.18.5.18"},{"key":"13816","doi-asserted-by":"crossref","unstructured":"Crawshaw A, Marshall J, Bartolo DC, et al. Evaluating gravity versus pump irrigation for bowel dysfunction. Gastrointest Nurs. 2009;7(7):34-42. https:\/\/doi.org\/10.12968\/gasn.2009.7.7.44267","DOI":"10.12968\/gasn.2009.7.7.44267"},{"key":"13817","unstructured":"Association of the British Pharmaceutical Industry (ABPI). Our industry: facts, figures and industry data. https:\/\/www.abpi.org.uk\/facts-figures-and-industry-data\/. (Accessed June 2024)."},{"key":"13818","unstructured":"Ministero della Salute. Gazzetta Ufficiale. Prestazioni Di Assistenza Specialistica Ambulatoriale \u2013 Allegato 3. Jan. 28, 2013. https:\/\/www.gazzettaufficiale.it\/atto\/serie_generale\/caricaArticolo?art.progressivo=0&art.idArticolo=1&art.versione=1&art.codiceRedazionale=13A00528&art.dataPubblicazioneGazzetta=2013-01-28&art.idGruppo=0&art.idSottoArticolo1=10&art.idSottoArticolo=1&art.flagTipoArticolo=3 (Accessed June 2024)"},{"key":"13819","unstructured":"Ministero della Salute. Gazzetta Ufficiale. Tariffe Delle Prestazioni Di Assistenza Ospedaliera Per Acuti, Per Tipo Di Ricovero \u2013 Allegato 1. Jan. 28, 2013. https:\/\/www.gazzettaufficiale.it\/atto\/serie_generale\/caricaArticolo?art.progressivo=0&art.idArticolo=1&art.versione=1&art.codiceRedazionale=13A00528&art.dataPubblicazioneGazzetta=2013-01-28&art.idGruppo=0&art.idSottoArticolo1=10&art.idSottoArticolo=1&art.flagTipoArticolo=1. (Accessed June 2024)"},{"key":"13820","unstructured":"UK Drug Database. UK Drug Information. https:\/\/www.drugs.com\/uk\/. (Accessed June 2024)."},{"key":"13821","unstructured":"Analytic Health. Data-driven actionable insights. https:\/\/analytichealth.co.uk\/pharmly-analytics\/?gad_source=1&gclid=CjwKCAjwoJa2BhBPEiwA0l0ImNRj_Zmn4lLZR2Wf11K0lJqivzDeS_Zi0nAcbk6vo1xUnI2bIvvHlRoCiUoQAvD_BwE. (Accessed June 2024)."},{"key":"13822","unstructured":"National Health System Business Service Authority (NHS BSA). NHS Prescription Services, Drug Tariff. https:\/\/www.nhsbsa.nhs.uk\/pharmacies-gp-practices-and-appliance-contractors\/drug-tariff. (Accessed June 2024)."},{"key":"13823","doi-asserted-by":"crossref","unstructured":"Fattore G. A proposal for guidelines for the economic evaluation of health interventions in Italy. PharmacoEcon Ital Res Artic. 2009;11(2):83-93. https:\/\/doi.org\/10.1007\/BF03320660","DOI":"10.1007\/BF03320660"},{"key":"13824","doi-asserted-by":"crossref","unstructured":"Ruggeri M, Signorini A, Caravaggio S, et al. Estimation model for healthcare costs and intensive care units access for Covid-19 patients and evaluation of the effects of remdesivir in the Portuguese context: hypothetical study. Clin Drug Investig. 2022;42(4):345-354. https:\/\/doi.org\/10.1007\/s40261-022-01128-8 PMID:35298832","DOI":"10.1007\/s40261-022-01128-8"},{"key":"13825","doi-asserted-by":"crossref","unstructured":"Ruggeri M, Signorini A, Caravaggio S, et al. Modeling the potential impact of remdesivir treatment for hospitalized patients with COVID-19 in Saudi Arabia on healthcare resource use and direct hospital costs: a hypothetical study. Clin Drug Investig. 2022;42(8):669-678. https:\/\/doi.org\/10.1007\/s40261-022-01177-z PMID:35838880","DOI":"10.1007\/s40261-022-01177-z"},{"key":"13826","doi-asserted-by":"crossref","unstructured":"Ruggeri M, Signorini A, Drago C, Rosiello F, Marchetti M. Model for estimating the healthcare costs and capacity of intensive care units in Italy in the treatment of patients with COVID-19: remdesivir impact assessment. AboutOpen. 2020;7(1):95-102. https:\/\/doi.org\/10.33393\/abtpn.2020.2213","DOI":"10.33393\/abtpn.2020.2213"},{"key":"13827","doi-asserted-by":"crossref","unstructured":"Rechel B. Funding for public health in Europe in decline? Health Policy. 2019;123(1):21-26. https:\/\/doi.org\/10.1016\/j.healthpol.2018.11.014 PMID:30509874","DOI":"10.1016\/j.healthpol.2018.11.014"}],"container-title":["Global and Regional Health Technology Assessment"],"original-title":[],"link":[{"URL":"https:\/\/journals.aboutscience.eu\/index.php\/grhta\/article\/download\/3168\/3795","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.aboutscience.eu\/index.php\/grhta\/article\/download\/3168\/3796","content-type":"application\/epub+zip","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.aboutscience.eu\/index.php\/grhta\/article\/download\/3168\/3797","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.aboutscience.eu\/index.php\/grhta\/article\/download\/3168\/3795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T13:24:44Z","timestamp":1731936284000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.aboutscience.eu\/index.php\/grhta\/article\/view\/3168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,7,31]]}},"URL":"https:\/\/doi.org\/10.33393\/grhta.2024.3168","relation":{},"ISSN":["2283-5733","2284-2403"],"issn-type":[{"type":"electronic","value":"2283-5733"},{"type":"print","value":"2284-2403"}],"subject":[],"published":{"date-parts":[[2024,11,18]]}}}