{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:52:56Z","timestamp":1791445976396,"version":"4.3.3"},"reference-count":28,"publisher":"Aboutscience Srl","issue":"1","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Grhta"],"abstract":"<jats:p>Introduction: Intermittent catheterization is the standard of care for neurogenic bladder dysfunction; however,urinary tract infections (UTIs) remain a major clinical and economic complication in patients with multiple sclerosis(MS) or spinal cord injury (SCI). Micro-hole Zone Technology (MhZT), implemented in the Luja\u2122 catheter, isdesigned to support bladder emptying.Methods: A static 5-year budget impact model was developed from the perspective of the Italian National HealthService, assuming a stable eligible population and comparing a current scenario without Luja\u2122 with progressiveadoption from 5% to 25%. Direct medical costs of catheters and UTI management were included; no discountingwas applied. Deterministic scenario analyses explored uncertainty in clinical effect, UTI costs and uptake.Results: The eligible population included 64,600 users with SCI and 40,600 with MS. In patients with SCI, Luja\u2122adoption reduced cumulative 5-year expenditure from \u20ac 1,652.9 million to \u20ac 1,643.3 million, preventing 28,861 UTIs.In patients with MS, expenditure decreased from \u20ac 1,039.2 million to \u20ac 1,033.1 million, preventing 18,139 UTIs. Overall, the model estimated approximately 47,000 avoided UTIs and \u20ac 15.8 million in related savings.Conclusions: Under the model assumptions, gradual adoption of MhZT may be economically sustainable andpotentially cost-saving for the Italian National Health Service. Results are mainly driven by an indirectly estimatedreduction in UTIs and should be confirmed using comparative real-world evidence.<\/jats:p>","DOI":"10.33393\/grhta.2026.3943","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:14:13Z","timestamp":1791443653000},"page":"241-248","source":"Crossref","is-referenced-by-count":0,"title":["Budget impact of MhZT for intermittent catheterization in people with multiple sclerosis or spinal cord injury in Italy"],"prefix":"10.33393","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8199-068X","authenticated-orcid":false,"given":"Agostino","family":"Fortunato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-0302","authenticated-orcid":false,"given":"Filippo","family":"Rumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9294-1241","authenticated-orcid":false,"given":"Debora","family":"Antonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Basile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0163-7865","authenticated-orcid":false,"given":"Elena Maria","family":"Calosci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0347-088X","authenticated-orcid":false,"given":"Floriana","family":"D'Ambrosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7964-3348","authenticated-orcid":false,"given":"Eugenio","family":"Di Brino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7524-7847","authenticated-orcid":false,"given":"Alessandra","family":"Fiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Pappalardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Scardigno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5850-9865","authenticated-orcid":false,"given":"Ilaria","family":"Sciomenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Elisa","family":"Calabr\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18642","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"21104","doi-asserted-by":"crossref","unstructured":"Gajewski JB, Schurch B, Hamid R, et al. 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