{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:42:38Z","timestamp":1774478558535,"version":"3.50.1"},"reference-count":44,"publisher":"Aboutscience Srl","issue":"1","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Circ Biomark"],"abstract":"<jats:p>Background and aim:\u00a0The aim of the current study is to assess the relation between carotid intima-media thickness (CIMT) measurements, renal Doppler resistive index (RI) and serum levels of interleukin-13 (IL-13) and annexin-V (An-V) in children with idiopathic nephrotic syndrome (INS).\nMaterials and methods:\u00a0The present case-control study was conducted on 60 children with INS and 60 age- and sex-matched healthy children. All participants were subjected to evaluation of serum levels of IL-13 and An-V and ultrasound Doppler measurement of CIMT and renal RI.\nResults:\u00a0Patients expressed significantly higher An-V (5.9 \u00b1 2.6 vs. 2.1 \u00b1 0.8 ng\/mL, p&lt;0.001) and IL-13 (19.2 \u00b1 7.6 vs. 3.4 \u00b1 1.4 ng\/L) levels when compared with healthy counterparts. Moreover, it was shown that patients had significantly higher CIMT (0.49 \u00b1 0.06 vs. 0.35 \u00b1 0.03, p&lt;0.001) as compared to controls. No significant differences were noted between the studied groups regarding right or left RIs. Correlation analysis identified significant direct correlation between serum An-V levels and albumin\/creatinine ratio (ACR) (r = 0.55), cholesterol (r = 0.48), triglycerides (r = 0.36), IL-13 (r = 0.92) and CIMT (r = 0.53). Similar correlations could be found between serum IL-13 levels and CIMT measurements and the corresponding parameters.\nConclusions:\u00a0The present study suggests an association between higher early atherosclerosis expressed as elevated CIMT measurements in children with INS and elevated serum levels of An-V and IL-13.<\/jats:p>","DOI":"10.33393\/jcb.2024.2689","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T14:03:28Z","timestamp":1718719408000},"page":"7-13","source":"Crossref","is-referenced-by-count":2,"title":["Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome"],"prefix":"10.33393","volume":"13","author":[{"given":"Asmaa","family":"Elsehmawy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha Mahmoud","family":"Gouda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Elzhraa Ahmed","family":"Diab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola Ismail","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba Mohamed","family":"Galal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona Gamal El Din","family":"Al Anany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salwa Samir","family":"Abd Elgwad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa Mohsen","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Ahmed Mostafa Kamal","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Yousri","family":"Elamir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18642","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"12248","unstructured":"Chanchlani R, Parekh RS. 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