{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:31:18Z","timestamp":1783391478288,"version":"3.54.6"},"reference-count":20,"publisher":"Aboutscience Srl","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Circ Biomark"],"abstract":"<jats:p>Introduction: The objective of this study was to conduct a comparative evaluation of systemic inflammatorymarkers in various forms of gallbladder inflammation in patients with acute calculous cholecystitis (ACC).Methods: The article presents information about a scientific study conducted to study the content of peripheralblood leukocytes, taking into account the form of ACC in 116 patients. The patients were divided into two groups:Group I consisted of 53 patients with the catarrhal form of ACC, and Group II included 63 patients with thedestructive forms (phlegmonous and gangrenous). Dynamic studies conducted before and after cholecystectomyin 116 patients showed that the level of leukocytes depended on the form of ACC.Results: The cell indices evaluated in this study, such as lymphocyte neutrophil ratio (LNR), lymphocyte monocyteratio (LMR), neutrophil lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR), and systemic inflammationresponse index (SIRI), present a more accessible and efficient alternative to assess systemic inflammation in clinicalpractice, especially in the context of acute cholecystitis.Conclusion: Systemic inflammatory cell biomarkers, such as the LNR, LMR, NLR, MLR, LER , and SIRI, are significantlyassociated with the clinical forms of ACC and provide useful insights into the intensity of the inflammatoryprocess in the gallbladder.<\/jats:p>","DOI":"10.33393\/jcb.2026.3624","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T08:11:10Z","timestamp":1769415070000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Association of systemic inflammatory biomarkers with the clinical forms of acute cholecystitis"],"prefix":"10.33393","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9820-4746","authenticated-orcid":false,"given":"Novruz","family":"Hajiyev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jabbar","family":"Hajiyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najiba","family":"Eynullayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidadi","family":"Allahverdiyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elman","family":"Tagisoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismayil","family":"Gafarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18642","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"18719","doi-asserted-by":"crossref","unstructured":"Gutt C, Schl\u00e4fer S, Lammert F. The treatment of gallstone disease. Dtsch Arztebl Int. 2020;117(9):148-158. https:\/\/doi.org\/10.3238\/arztebl.2020.0148 PMID: 32234195","DOI":"10.3238\/arztebl.2020.0148"},{"key":"18720","doi-asserted-by":"crossref","unstructured":"Hajiyev NJ, Sultanova MJ, Eynullayeva NA, et al. Peripheral blood leukocyte content in acute calculous cholecystitis: dependence on the clinical form of the disease. Azerbaijan Medical Journal. 2024;4:11\u201316. https:\/\/doi.org\/10.34921\/amj.2024.4.002","DOI":"10.34921\/amj.2024.4.002"},{"key":"18721","unstructured":"Eynullayeva NA, Hajiyev NJ, Sultanova MJ. The role of ultrasound scan in the diagnosis of destructive forms of acute cholecystitis. Abstract of the 20th International Euroasian Congress of Surgery and Hepatogastroenterology. 2024;65."},{"key":"18722","doi-asserted-by":"crossref","unstructured":"Pyfrom DP, Ali MZ, Ghouse F, et al. The use of systemic inflammatory response syndrome (SIRS) and elevated liver enzymes as predictive factors of gangrenous cholecystitis: a case report. Cureus. 2023;15(2):e34727. https:\/\/doi.org\/10.7759\/cureus.34727 PMID:36909064","DOI":"10.7759\/cureus.34727"},{"key":"18723","unstructured":"Hamdamov BZ, Musoev TY, Khaydarov FN, et al. Dynamics of cytokine blood profile at destructive forms of acute calculus cholecystitis. Eur J Psychol. 2021;17(3):93-101."},{"key":"18724","doi-asserted-by":"crossref","unstructured":"Li Q, Ma X, Shao Q, et al. Prognostic impact of multiple lymphocyte-based inflammatory indices in acute coronary syndrome patients. Front Cardiovasc Med. 2022;9:811790. https:\/\/doi.org\/10.3389\/fcvm.2022.811790 PMID:35592392","DOI":"10.3389\/fcvm.2022.811790"},{"key":"18725","doi-asserted-by":"crossref","unstructured":"Varman A, Alkan S. Evaluation of neutrophil\/lymphocyte ratio, platelet\/lymphocyte ratio, mean platelet volume, and neutrophil\/monocyte ratio in patients with benign breast lesions. Bratisl Lek Listy. 2021;122(7):489-492. https:\/\/doi.org\/10.4149\/BLL_2021_079 PMID:34161116","DOI":"10.4149\/BLL_2021_079"},{"key":"18726","doi-asserted-by":"crossref","unstructured":"Xu X, Cai L, Chen T, et al. Predictive value of inflammation-based Glasgow prognostic score, platelet-lymphocyte ratio, and global registry of acute coronary events score for major cardiovascular and cerebrovascular events during hospitalization in patients with acute myocardial infarction. Aging (Albany, NY). 2021;13(14):18274-18286. https:\/\/doi.org\/10.18632\/aging.203273 PMID:34270463","DOI":"10.18632\/aging.203273"},{"key":"18727","doi-asserted-by":"crossref","unstructured":"Kahraman S, Agus HZ, Avci Y, et al. The neutrophil to lymphocyte ratio (NLR) is associated with residual syntax score in patients with ST-segment elevation myocardial infarction. Angiology. 2021;72(2):166-173. https:\/\/doi.org\/10.1177\/0003319720958556 PMID:32945176","DOI":"10.1177\/0003319720958556"},{"key":"18728","doi-asserted-by":"crossref","unstructured":"Dziedzic EA, G\u0105sior JS, Tuzimek A, et al. Investigation of the associations of novel inflammatory biomarkers \u2013 Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI) \u2013 with the severity of coronary artery disease and acute coronary syndrome occurrence. Int J Mol Sci. 2022;23(17):9553. https:\/\/doi.org\/10.3390\/ijms23179553 PMID:36076952","DOI":"10.3390\/ijms23179553"},{"key":"18729","doi-asserted-by":"crossref","unstructured":"Han K, Shi D, Yang L, et al. Prognostic value of systemic inflammatory response index in patients with acute coronary syndrome undergoing percutaneous coronary intervention. 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