{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:02:58Z","timestamp":1777075378400,"version":"3.51.4"},"reference-count":16,"publisher":"Korean Neurosurgical Society","issue":"4","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002449","name":"Jeju National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jkns.or.kr"],"crossmark-restriction":true},"short-container-title":["J Korean Neurosurg Soc"],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:p>Objective : Chiari II malformation (CM II) is still the main cause of severe morbidity and mortality in children with open neural tube defects (ONTDs). The goal of this study was to validate a CM II model in late-stage chick embryos with surgically induced ONTDs.Methods : To make the chick embryo model of ONTD, their neural tubes were opened for a length of 5\u20136 somites at the thoracic level in Hamburger and Hamilton stage 18 chick embryos (n=150). They were reincubated &lt;i&gt;in ovo&lt;\/i&gt;. up to a total age of 17\u201321 days. A total of 19 embryos survived and were assigned to either the postoperative day (POD) 14\u201315 group (n=6) or the POD 17\u201318 group (n=13). Magnetic resonance imaging (MRI) and histopathologic findings of embryo heads with spinal ONTDs were compared with age-matched normal chick embryos.Results : The chick embryos with ONTDs demonstrated definite and constant structural changes, such as downward displacement of the cerebellum to just above the foramen magnum and narrow and small cerebrospinal fluid spaces in the crowded small posterior fossa. These morphologic features were more prominent in the POD 17\u201318 group than in the POD 14\u201315 group.Conclusion : This is the first description of CM II with spinal ONTD in a late-stage chick embryo model with MRI and histopathological analysis. The morphological changes of the posterior fossa in this study mimic those of CM II associated with spinal ONTD in humans. This model will facilitate investigation of the pathogenesis of CM II.<\/jats:p>","DOI":"10.3340\/jkns.2022.0144","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T07:21:25Z","timestamp":1671520885000},"page":"393-399","update-policy":"https:\/\/doi.org\/10.3340\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chiari Malformation with Surgically Induced Open Neural Tube Defect in Late Chick Embryos : Characterization by Magnetic Resonance Imaging and Histopathological Analysis"],"prefix":"10.3340","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-0607","authenticated-orcid":true,"given":"In Sung","family":"Hwang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8238-2043","authenticated-orcid":true,"given":"Kyung Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2281-1221","authenticated-orcid":true,"given":"Ki Bum","family":"Sim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1892","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2003.50078"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420520509"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.12.046"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-009-1459-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/02841850410003572"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000121188"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000120432"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.108867"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198308000-00007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11610-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.1996.11.6.509"},{"key":"ref13","first-page":"25","volume-title":"A study for normal development of the posterior cranial fossa in the chick embryos (gestation 14-20 days) with MR images and histopathology","author":"Sim","year":"2005"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000086827"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8454-5-7"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.151076"}],"container-title":["Journal of Korean Neurosurgical Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/jkns.or.kr\/upload\/pdf\/jkns-2022-0144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jkns.or.kr\/journal\/view.php?doi=10.3340\/jkns.2022.0144","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jkns.or.kr\/upload\/pdf\/jkns-2022-0144.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:45:54Z","timestamp":1688431554000},"score":1,"resource":{"primary":{"URL":"http:\/\/jkns.or.kr\/journal\/view.php?doi=10.3340\/jkns.2022.0144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"URL":"https:\/\/doi.org\/10.3340\/jkns.2022.0144","relation":{},"ISSN":["2005-3711","1598-7876"],"issn-type":[{"value":"2005-3711","type":"print"},{"value":"1598-7876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,1]]},"assertion":[{"value":"2022-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-20","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-01","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}