{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T05:40:13Z","timestamp":1774158013661,"version":"3.50.1"},"reference-count":50,"publisher":"Korean Neurosurgical Society","issue":"3","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["jkns.or.kr"],"crossmark-restriction":true},"short-container-title":["J Korean Neurosurg Soc"],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:p>While the survival rate of preterm infants has increased dramatically over the last few decades, intraventricular hemorrhage and subsequent hydrocephalus remain major unsolved problems in neonatal intensive care. Once intraventricular hemorrhage occurs, severe neurological sequelae are inevitable. Treatment of this complicated pathology and achievement of favorable neurofunctional outcomes in fragile infants are crucial challenges for pediatric neurosurgeons. Fibrinolytic therapy, which chemically dissolves hematoma, is a promising and useful treatment method. In this paper, the historical background of fibrinolytic therapy for postintraventricular hemorrhagic hydrocephalus in preterm infants is reviewed and a recent method of fibrinolytic therapy using urokinase is introduced.<\/jats:p>","DOI":"10.3340\/jkns.2022.0258","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T06:09:50Z","timestamp":1673849390000},"page":"263-273","update-policy":"https:\/\/doi.org\/10.3340\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fibrinolytic (Thrombolytic) Therapy for Post Intraventricular Hemorrhagic Hydrocephalus in Preterm Infants"],"prefix":"10.3340","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2271-1332","authenticated-orcid":true,"given":"Young Soo","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1892","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0423"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/bf00417665"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3171\/2020.5.peds20211"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000331797"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-021-05206-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3171\/2015.7.peds15140"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.08.014"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.04.169"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-022-05606-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.07.079"},{"key":"ref11","first-page":"137","volume-title":"Early endoscopic ventricular irrigation for the treatment of neonatal posthemorrhagic hydrocephalus: a feasible treatment option or not? A multicenter study","author":"Etus","year":"2018"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.05.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb15186.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s0887-8994(97)00130-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318594"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-021-05373-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000121207"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2022.37.e263"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-021-05400-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2724"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318231"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3171\/2014.7.peds14322"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3171\/2019.12.peds19381"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(78)80282-0"},{"key":"ref25","first-page":"51","volume-title":"","author":"Park","year":"2022"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2176\/jns-nmc.2022-0100"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-020-04766-5"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/bf01428504"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s003810000418"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb02834.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200102000-00013"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3171\/2014.2.peds13397"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10244"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-016-3217-9"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3171\/2020.2.peds2037"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.74.1.0081"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250103"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250202"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.190173"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2841"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1960"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13795.x"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1007\/bf02075763"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.4.759"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.1_spec_no.12"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1136\/fn.75.1.f20"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1416"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/s0967-5868(03)00028-6"},{"key":"ref50","first-page":"e309","volume-title":"Two-year outcomes of Korean very low birth weight infants born in 2013-2014","author":"Youn","year":"2018"}],"container-title":["Journal of Korean Neurosurgical Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/jkns.or.kr\/upload\/pdf\/jkns-2022-0258.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jkns.or.kr\/journal\/view.php?doi=10.3340\/jkns.2022.0258","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jkns.or.kr\/upload\/pdf\/jkns-2022-0258.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T06:13:28Z","timestamp":1683785608000},"score":1,"resource":{"primary":{"URL":"http:\/\/jkns.or.kr\/journal\/view.php?doi=10.3340\/jkns.2022.0258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,1]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"URL":"https:\/\/doi.org\/10.3340\/jkns.2022.0258","relation":{},"ISSN":["2005-3711","1598-7876"],"issn-type":[{"value":"2005-3711","type":"print"},{"value":"1598-7876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,1]]},"assertion":[{"value":"2022-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-16","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-01","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}