{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:11:54Z","timestamp":1778224314214,"version":"3.51.4"},"reference-count":66,"publisher":"Korean Neurosurgical Society","issue":"3","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["jkns.or.kr"],"crossmark-restriction":true},"short-container-title":["J Korean Neurosurg Soc"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>Objective : Alzheimer\u2019s disease is a progressive neurodegenerative disorder characterized by amyloid-beta (A\u03b2) peptide aggregation, representing a major therapeutic target. Emerging evidence suggests certain chemotherapeutic agents may attenuate A\u03b2 pathology.Methods : This study investigated the effects of imatinib, a tyrosine kinase inhibitor with limited blood-brain barrier (BBB) penetration, and nilotinib, with enhanced BBB permeability, in an intracerebroventricular streptozotocin (ICV-STZ) rat model of Alzheimer\u2019s disease. Outcomes included behavioral assessments (learning latency), hippocampal CA1 and CA3 neuronal counts, and brain concentrations of tumor necrosis factor (TNF)-\u03b1, nuclear factor kappa B (NF-\u03baB), brain-derived neurotrophic factor (BDNF), and neuregulin-1 (NRG-1).Results : ICV-STZ administration significantly elevated TNF-\u03b1 and NF-\u03baB levels and reduced BDNF and NRG-1 expression. Both imatinib and nilotinib mitigated these alterations, with imatinib demonstrating greater efficacy despite its limited BBB permeability. Imatinib and nilotinib reduced TNF-\u03b1 and NF-\u03baB levels, increased BDNF and NRG-1 expression, and significantly improved cognitive performance, with latency periods extending from 69.8 seconds in the disease model to 193.5 and 183.1 seconds, respectively.Conclusion : Imatinib and nilotinib ameliorated neuroinflammation, restored neurotrophic support, and improved cognitive deficits in a preclinical Alzheimer\u2019s disease model. These findings highlight the therapeutic potential of tyrosine kinase inhibitors, warranting further translational research in human studies.<\/jats:p>","DOI":"10.3340\/jkns.2025.0110","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T23:45:29Z","timestamp":1762818329000},"page":"421-432","update-policy":"https:\/\/doi.org\/10.3340\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Evaluation of Imatinib and Nilotinib in a Streptozotocin-Induced Rat Model of Alzheimer\u2019s Disease : Neuroprotective, Anti-inflammatory, and Cognitive Outcomes"],"prefix":"10.3340","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-1014","authenticated-orcid":true,"given":"Gokhan","family":"Gurkan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Izmir Economy University Medical Point Hospital, Izmir, 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