{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:09:05Z","timestamp":1788761345217,"version":"build-2803163510"},"reference-count":26,"publisher":"Korean Neurosurgical Society","issue":"5","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["jkns.or.kr"],"crossmark-restriction":true},"short-container-title":["J Korean Neurosurg Soc"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>Objective : Early oral or enteral nutrition (EN) is recommended for critically ill patients; however, individuals with traumatic brain injury (TBI) often fail to meet their nutritional goals. Supplementary parenteral nutrition (SPN) in this instance may be of benefit, but evidence is lacking. This study examined the association between early SPN and nutritional adequacy and clinical outcomes in patients with TBI.Methods : This retrospective, non-randomized, single-center cohort study analyzed adult patients with TBI admitted to a trauma intensive care unit (ICU) from January 2023 to December 2024. Patients who received oral nutrition or EN on hospital day 4 (HD4) were included and classified based on their use of SPN. We assessed total caloric and protein intake on HD4, as well as survival rates, lengths of ICU and hospital stays, the occurrence of infectious complications, and unplanned ICU readmissions.Results : Among 260 screened patients, 122 were included in the study. The SPN group achieved higher caloric intake (1508 vs. 852 kcal; &lt;i&gt;p&lt;\/i&gt;&lt;0.05) and total protein intake (79 vs. 41 g; &lt;i&gt;p&lt;\/i&gt;&lt;0.05). Additionally, SPN was associated with lower rates of urinary tract infections (19.7% vs. 44.3%; &lt;i&gt;p&lt;\/i&gt;=0.004) and unplanned ICU readmissions (9.8% vs. 31.1%; &lt;i&gt;p&lt;\/i&gt;=0.004). Logistic regression analysis revealed a reduced risk for urinary tract infections (odds ratio [OR], 0.38; &lt;i&gt;p&lt;\/i&gt;=0.026) and unplanned ICU readmissions (OR, 0.25; &lt;i&gt;p&lt;\/i&gt;=0.007).Conclusion : Early SPN was associated with improved caloric and protein delivery and fewer infectious complications and unplanned ICU readmissions in TBI patients. Despite several limitations, these results suggest that SPN may be a beneficial strategy when oral or EN alone is inadequate.<\/jats:p>","DOI":"10.3340\/jkns.2026.0042","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:19:23Z","timestamp":1784157563000},"page":"770-778","update-policy":"https:\/\/doi.org\/10.3340\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Early Supplemental Parenteral Nutrition with Clinical Outcomes in Patients with Traumatic Brain Injury"],"prefix":"10.3340","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3641-7196","authenticated-orcid":true,"given":"Heejin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Uijeongbu St. Mary\u2019s Hospital, Uijeongbu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2451-8581","authenticated-orcid":true,"given":"Jingyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Uijeongbu St. Mary\u2019s Hospital, Uijeongbu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9287-5097","authenticated-orcid":true,"given":"Jihyeon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Nutrition Team, Uijeongbu St. Mary\u2019s Hospital, Uijeongbu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3923-7835","authenticated-orcid":true,"given":"Mihwa","family":"Jang","sequence":"additional","affiliation":[{"name":"Nursing Team, Uijeongbu St. Mary\u2019s Hospital, Uijeongbu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-3186","authenticated-orcid":true,"given":"Eunyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-0125","authenticated-orcid":true,"given":"Dae-Sang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6174-7579","authenticated-orcid":true,"given":"Min Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7255-7058","authenticated-orcid":true,"given":"Hyung Sun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care, Section of Critical Care Medicine, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8973-5622","authenticated-orcid":true,"given":"Maru","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1892","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4880-3","type":"journal-article"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.08.494","type":"journal-article"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1102662","type":"journal-article"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2020.02.008","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2267","type":"journal-article"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/0884533617691745","type":"journal-article"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10353-025-00872-3","type":"journal-article"},{"key":"ref8","first-page":"505","type":"journal-article","volume-title":"Tracheal intubation in traumatic brain injury: a multicentre prospective observational 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