{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:07:39Z","timestamp":1787026059731,"version":"build-2736575974"},"reference-count":46,"publisher":"Korean Ophthalmological Society","issue":"4","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002569","name":"Wonkwang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ekjo.org"],"crossmark-restriction":true},"short-container-title":["Korean J Ophthalmol"],"published-print":{"date-parts":[[2021,8,5]]},"abstract":"<jats:p>Purpose: The purpose of this study was to determine the efficacy and safety of selective intra-arterial thrombolysis in patients with central retinal artery occlusion (CRAO).Methods: Medical records for 44 eyes of 44 patients diagnosed with acute non-arteritic CRAO and thrombolysis between October 2010 and February 2019 were analyzed retrospectively. Based on visual acuity, fundoscopic findings, and fluorescein angiography, the patients were classified into three stages: incomplete, subtotal, and total. The perfusion state using the best-corrected visual acuity (BCVA), arm to retina time, and arteriovenous passage times, after 1 month, 6 months, and at the final visit after the procedure, were compared with baseline readings.Results: Improvement of visual acuity was confirmed in 31 out of 44 patients (70.45%). The mean BCVA of 44 patients changed from 1.65 \u00b1 0.78 logarithmic minimum angle of resolution (logMAR) at the first visit to 1.18 \u00b1 0.91 logMAR at the last visit (p = 0.114). The BCVA according to CRAO stage was 0.08 \u00b1 0.11 logMAR for the incomplete stage at the first visit, 0.06 \u00b1 0.05 logMAR (p = 0.933) 1 month after the procedure, and 0.05 \u00b1 0.07 logMAR (p = 0.933) at the last visit. In the subtotal stage, the results were 1.81 \u00b1 0.54 logMAR at the first visit, 1.63 \u00b1 0.76 logMAR (p = 0.035) 1 month after the procedure, and 1.36 \u00b1 0.85 logMAR (p = 0.014) at the last visit. For the total stage of BCVA, the result at the first visit was 2.36 \u00b1 0.25 logMAR, and it was 2.30 \u00b1 0.30 logMAR (p = 0.510) 1 month after the procedure, and 2.42 \u00b1 0.30 logMAR (p = 0.642) at the last visit. Reperfusion was observed in 40 patients out of the 44 (90.91%).Conclusions: Selective intra-arterial thrombolysis can be helpful in patients with subtotal CRAO in terms of visual improvement and retinal arterial reperfusion.<\/jats:p>","DOI":"10.3341\/kjo.2020.0082","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T04:42:17Z","timestamp":1624250537000},"page":"261-271","update-policy":"https:\/\/doi.org\/10.3341\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Safety and Efficacy of Selective Intra-arterial Thrombolysis for Central Retinal Artery Occlusion"],"prefix":"10.3341","volume":"35","author":[{"given":"Sang Jun","family":"Ko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Choel","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Sung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Sik","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1893","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.05.014"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.038"},{"key":"ref3","first-page":"2489","volume-title":"Intra-arterial thrombolysis for central retinal artery occlusion","author":"Hakim","year":"2019"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.111.613653"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.22608\/apo.201871"},{"key":"ref6","first-page":"1597","volume-title":"Management of acute retinal ischemia: follow the guidelines!","author":"Biousse","year":"2018"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/iio.0000000000000087"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.25"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(99)00359-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd001989.pub2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(95)30758-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/1538574416682158"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/nrl.0000000000000129"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016687578"},{"key":"ref15","first-page":"1301","volume-title":"Prognosis of central retinal artery occlusion: local intraarterial fibrinolysis versus conservative treatment","author":"Schmidt","year":"2002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.037135"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(99)90165-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1017\/s0317167100004522"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.29.10.2076"},{"key":"ref20","first-page":"950","volume-title":"Multicenter study of the European Assessment Group for Lysis in the Eye (EAGLE) for the treatment of central retinal artery occlusion: design issues and implications. 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