{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:35:12Z","timestamp":1784028912513,"version":"3.55.0"},"reference-count":41,"publisher":"Korean Ophthalmological Society","issue":"2","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ekjo.org"],"crossmark-restriction":true},"short-container-title":["Korean J Ophthalmol"],"published-print":{"date-parts":[[2023,4,5]]},"abstract":"<jats:p>Purpose: Thyroid receptor antibodies can quantify thyroid eye disease activity, predict outcomes and aid timing of interventions. The type and generation of assay is frequently unspecified, complicating meta-analyses. To determine the clinical and biochemical relationships between a second-generation thyrotropin receptor-binding inhibition antibody (TRAb) immunoassay, detecting stimulatory and blocking antibodies, with the thyroid stimulating immunoglobulin (TSI) bridging immunoassay detecting the stimulatory component only.Methods: Retrospective review of 100 consecutive patients attending a regional specialist service. For each patient and visit, both a TRAb and TSI were performed, and a clinical activity score (CAS) recorded.Results: A significant positive correlation between TRAb and TSI (rho = 0.828, &lt;i&gt;p&lt;\/i&gt; &lt; 0.01) but a weaker correlation between the assays and CAS (TRAb: rho = 0.439, &lt;i&gt;p&lt;\/i&gt; &lt; 0.01; TSI: r = 0.357, &lt;i&gt;p&lt;\/i&gt; &lt; 0.01) were found. In 10% of the episodic data, patients had a TRAb level that was disproportionately high (39.41 \u00b1 52.84 IU\/L), compared to their TSI levels (9.53 \u00b1 12.10 IU\/L) with a higher-than-average CAS (2.47 \u00b1 1.78; range, 0\u20135). Within 12 months of diagnosis, a significant positive correlation between CAS and TRAb (rho = 0.503, &lt;i&gt;p&lt;\/i&gt; &lt; 0.01) as well as between CAS and TSI (rho = 0.329, &lt;i&gt;p&lt;\/i&gt; &lt; 0.01) were found. In patients with a diagnosis over 12 months, the correlation with CAS for both TSI and TRAb were Spearman rank correlation coefficient of 0.347 (&lt;i&gt;p&lt;\/i&gt; &lt; 0.01) and 0.327 (&lt;i&gt;p&lt;\/i&gt; &lt; 0.01), respectively.Conclusions: TRAb and TSI correlate strongly and to a lesser extent with the CAS. For most patients, TRAb can be replaced with the more economical TSI. TRAb also correlates better with newly diagnosed, more active patients than TSI. In a subset of patients, blocking antibodies may play a significant pathogenic role, requiring different treatment and monitoring. Further studies are required to investigate this relationship.<\/jats:p>","DOI":"10.3341\/kjo.2022.0131","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T01:20:35Z","timestamp":1680744035000},"page":"147-156","update-policy":"https:\/\/doi.org\/10.3341\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Thyrotropin Receptor Autoantibody Assessment in Thyroid Eye Disease: Does the Assay Type 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