{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:50:45Z","timestamp":1746499845677},"reference-count":37,"publisher":"Korean Ophthalmological Society","issue":"5","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008130","name":"Pusan National University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ekjo.org"],"crossmark-restriction":true},"short-container-title":["Korean J Ophthalmol"],"published-print":{"date-parts":[[2023,10,5]]},"abstract":"<jats:p>Purpose: This study aimed to evaluate the 1-year surgical outcomes of XEN45 gel stent implantation with an open conjunctiva approach in patients with open-angle glaucoma (OAG).Methods: This retrospective cohort study included 19 eyes of 19 patients who underwent XEN45 gel stent implantation with an open conjunctival approach. Surgical success was defined by intraocular pressure (IOP) \u226418 mmHg and one of the following: IOP reduction \u226530% or reduction of two glaucoma medications with final IOP if baseline IOP \u226418 mmHg. The cumulative probability of success rate was analyzed using Kaplan-Meier survival analysis. Cox proportional hazard regression analysis was used to assess prognostic factors for surgical failure.Results: IOP reduced from 32.37 \u00b1 12.08 mmHg preoperatively to 15.14 \u00b1 2.25 mmHg at 1 year (&lt;i&gt;p&lt;\/i&gt; = 0.001). The number of glaucoma medication reduced from 3.89 \u00b1 0.32 preoperatively to 0.86 \u00b1 1.35 at 1 year (&lt;i&gt;p&lt;\/i&gt; = 0.001). The success rates were 78.9% at 6 months and 73.7% at 1 year. Eyes with bleb horizontal extent \u22652 clock hours at 1 month postoperatively had a significantly higher success rate (log-rank test, &lt;i&gt;p&lt;\/i&gt; &lt; 0.001). Greater bleb horizontal extent at 2 weeks and 1 month postoperatively was associated with a lower surgical failure rate (2 weeks: hazard ratio, 0.119; &lt;i&gt;p&lt;\/i&gt; = 0.024; 1 month: hazard ratio, 0.046; &lt;i&gt;p&lt;\/i&gt; = 0.007). Bleb needling and additional glaucoma surgeries were necessary in 10 (52.6%) and five eyes (26.3%), respectively.Conclusions: XEN45 gel stent implantation with the open conjunctiva approach is effective in reducing IOP and glaucoma medication for over 1 year in patients with OAG.<\/jats:p>","DOI":"10.3341\/kjo.2023.0044","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T23:33:03Z","timestamp":1691537583000},"page":"353-364","update-policy":"http:\/\/dx.doi.org\/10.3341\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["One-Year Outcomes of Ab Externo XEN45 Gel Stent Implantation with an Open Conjunctiva Approach in Patients with Open-Angle 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