{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:29:09Z","timestamp":1772638149401,"version":"3.50.1"},"reference-count":40,"publisher":"Korean Ophthalmological Society","issue":"5","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ekjo.org"],"crossmark-restriction":true},"short-container-title":["Korean J Ophthalmol"],"published-print":{"date-parts":[[2024,10,5]]},"abstract":"<jats:p>Purpose: There has been a lack of data on health-related quality of life (HRQoL) in children with vernal keratoconjunctivitis (VKC) from Southeast Asia. This study evaluated the levels (mean total score and subscales score) of HRQoL, comparing the VKC and normal children groups, and within the VKC severity groups.Methods: A cross-sectional study was conducted in two tertiary hospitals, specifically the pediatric ophthalmology services at Hospital Selayang and Universiti Sains Malaysia, spanning from 2019 to 2020. Participants aged between 8 and 15 years were categorized into two groups: those diagnosed with VKC and healthy children serving as the control group. Each participant completed the Quality of Life in Children with Vernal Keratoconjunctivitis (QUICK) questionnaire, consisting of 16 questions, divided into two subscales: 12 questions focusing on symptoms and four questions for daily activities.Results: A total of 240 children took part in the study, with 120 children diagnosed with VKC and another 120 in the control group. The mean age of participants with VKC was 11.21 \u00b1 1.91 years, with a male predominance of 4:1 compared to female. Tearing (98.4%) and itchiness (98.3%) emerged as the most prevalent symptoms affecting HRQoL, while the most challenging activities were outdoor play (36.6%) and participation in recreational water activities (34.2%). The mean total score was significantly higher in the VKC group compared to the control group. Additionally, both the mean total score and all subscale scores were significantly higher in the severe type compared to the mild-moderate type.Conclusions: VKC significantly reduce the HRQoL among Malaysian children, and the negative impact increases with the disease severity.<\/jats:p>","DOI":"10.3341\/kjo.2024.0048","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T01:14:21Z","timestamp":1724030061000},"page":"364-374","update-policy":"https:\/\/doi.org\/10.3341\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Health-related Quality of Life in Children with Vernal Keratoconjunctivitis in Malaysia"],"prefix":"10.3341","volume":"38","author":[{"given":"Kamalul Khusus","family":"Khairil-Ridzwan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen Sheng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chew Lee Min","family":"Fiona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Shatriah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1893","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.117812"},{"key":"ref2","first-page":"482","volume-title":"Epidemiology of allergic conjunctivitis: clinical appearance and treatment patterns in a population-based study","author":"Leonardi","year":"2015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/09286580802573177"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-301376"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215528"},{"key":"ref6","first-page":"226","volume-title":"Vernal keratoconjunctivitis among primary school students in Butajira town","author":"Kassahun","year":"2012"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-016-0345-7"},{"key":"ref8","first-page":"371","volume-title":"Prevalence of allergic conjunctivitis in school children of Karachi","author":"Baig","year":"2010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2020.03.005"},{"key":"ref10","first-page":"237","volume-title":"Allergic conjunctivitis","author":"Kosrirukvongs","year":"2001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/09273940802184182"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.882240"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/srep23858"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2017.7.2.57"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/djo.djo_42_18"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2015.1123737"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.03.041"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-311171"},{"key":"ref19","first-page":"64","volume-title":"Comparative evaluation of quality of life in patients of vernal keratoconjunctivitis treated with bepotastine besilate versus olopatadine and ketorolac combination in eye department at tertiary care hospital in Indian population","author":"Dahiya","year":"2019"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2022.100701"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.11.020"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1745243"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13520"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.7869\/djo.84"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/aci.0b013e3282efb726"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.06.028"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.04.023"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-3-67"},{"key":"ref29","volume-title":"","author":"Kolanu","year":"2016"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2021.1708"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.119431"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.11.018"},{"key":"ref33","first-page":"59","volume-title":"A cross-sectional study of refractive errors in vernal keratoconjunctivitis","author":"Shetty","year":"2018"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.18231\/j.ijceo.2020.016"},{"key":"ref35","first-page":"92","volume-title":"Profile of vernal keratoconjunctivitis in Nepal: a hospital based study","author":"Kansakar","year":"2011"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/945317"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.4103\/kjo.kjo_100_17"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(00)00092-0"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.11.016"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2013.874483"}],"container-title":["Korean Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ekjo.org\/upload\/pdf\/kjo-2024-0048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ekjo.org\/journal\/view.php?doi=10.3341\/kjo.2024.0048","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ekjo.org\/upload\/pdf\/kjo-2024-0048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T08:06:54Z","timestamp":1738742814000},"score":1,"resource":{"primary":{"URL":"http:\/\/ekjo.org\/journal\/view.php?doi=10.3341\/kjo.2024.0048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"URL":"https:\/\/doi.org\/10.3341\/kjo.2024.0048","relation":{},"ISSN":["1011-8942","2092-9382"],"issn-type":[{"value":"1011-8942","type":"print"},{"value":"2092-9382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,5]]},"assertion":[{"value":"2024-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-16","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-05","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}