{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:10:04Z","timestamp":1742170204006,"version":"3.38.0"},"reference-count":26,"publisher":"Korean Ophthalmological Society","issue":"1","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002543","name":"Pusan National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ekjo.org"],"crossmark-restriction":true},"short-container-title":["Korean J Ophthalmol"],"published-print":{"date-parts":[[2025,2,5]]},"abstract":"<jats:p>Purpose: To investigate ocular manifestation of immune reconstitution inflammatory syndrome (IRIS) in HIV patients after starting highly active antiretroviral therapy (HAART) and its relationship to T cell immunity.Methods: HIV patients with ocular IRIS after HAART were retrospectively reviewed. Clinical presentations with previous opportunistic infection, duration from initiation of HAART to IRIS, blood CD4+, CD8+ T cell count, and HIV RNA copies before HAART and at IRIS were analyzed.Results: Among 19 patients (27 eyes) included, the most common previous opportunistic infection was cytomegalovirus (17 patients, 89.5%) followed by tuberculosis choroiditis (2 patients, 10.5%). The clinical manifestations included vitritis (20 eyes, 74.0%), retinitis (14 eyes, 51.9%), and anterior uveitis (5 eyes, 18.5%). The median duration from initiation of HAART to IRIS was 70 days. CD4+ T cell count before HAART increased at IRIS (&lt;i&gt;p&lt;\/i&gt; &lt; 0.001). CD8+ T cell count before HAART was negatively correlated with duration from HAART to IRIS (&lt;i&gt;p&lt;\/i&gt; &lt; 0.001). The cutoff value of CD8+ T cell count for discerning early or late onset of ocular IRIS was 258\/mm&lt;sup&gt;3&lt;\/sup&gt; (&lt;i&gt;p&lt;\/i&gt; = 0.001). When divided into two groups by CD8+ T cell count of 258\/mm&lt;sup&gt;3&lt;\/sup&gt;, 90% patients with CD8+ T cell count higher than 258\/mm&lt;sup&gt;3&lt;\/sup&gt; before HAART developed ocular IRIS within 70 days.Conclusions: There was a negative relationship between CD8+ T cell count before HAART and duration from HAART to ocular IRIS. Ocular IRIS with higher CD8+ T cell count before HAART developed earlier after HAART initiation compared to those with lower CD8+ T cell count.<\/jats:p>","DOI":"10.3341\/kjo.2024.0133","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T01:34:31Z","timestamp":1737336871000},"page":"71-79","update-policy":"https:\/\/doi.org\/10.3341\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ocular Manifestations of Immune Reconstitution Inflammatory Syndrome in HIV after Highly Active Antiretroviral Therapy: Clinical Use of CD8+ T cell"],"prefix":"10.3341","volume":"39","author":[{"given":"Jae Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Ho","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hoon","family":"Ban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Soo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1893","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(10)70026-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1086\/503903"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000131375.21070.06"},{"key":"ref4","first-page":"213","volume-title":"Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy","author":"Shelburne","year":"2002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/coh.0b013e328302cc3d"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu291"},{"key":"ref7","first-page":"730","volume-title":"Cytomegalovirus retinitis after initiation of antiretroviral therapy","author":"Ahmadinejad","year":"2013"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(05)63177-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(01)01048-x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.03.021"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200102000-00001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1086\/508997"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl049"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1086\/342044"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2009.009439"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(08)70184-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200602000-00007"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/nri3862"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(00)00356-1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200308000-00009"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.067"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1080\/09273940802056307"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12348-016-0110-3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080\/13550280500511741"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-10-21"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.05.031"}],"container-title":["Korean Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ekjo.org\/upload\/pdf\/kjo-2024-0133.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ekjo.org\/journal\/view.php?doi=10.3341\/kjo.2024.0133","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ekjo.org\/upload\/pdf\/kjo-2024-0133.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T23:55:44Z","timestamp":1742169344000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ekjo.org\/journal\/view.php?doi=10.3341\/kjo.2024.0133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"URL":"https:\/\/doi.org\/10.3341\/kjo.2024.0133","relation":{},"ISSN":["1011-8942","2092-9382"],"issn-type":[{"type":"print","value":"1011-8942"},{"type":"electronic","value":"2092-9382"}],"subject":[],"published":{"date-parts":[[2025,2,5]]},"assertion":[{"value":"2024-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-05","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}