{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:03:11Z","timestamp":1792159391514,"version":"4.4.0"},"reference-count":25,"publisher":"Korean Ophthalmological Society","issue":"5","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Foundation for Retinal Research and Advancement"}],"content-domain":{"domain":["ekjo.org"],"crossmark-restriction":true},"short-container-title":["Korean J Ophthalmol"],"published-print":{"date-parts":[[2025,10,5]]},"abstract":"<jats:p>Purpose: To evaluate real-world functional and anatomical outcomes, treatment patterns, and ocular examination trends in diabetic macular edema (DME) in Korea.Methods: A prospective, multicenter, observational study was conducted at 17 hospitals (2017\u20132022) involving adults with DME. Patients were categorized into center-involving DME (CI-DME) and non-CI-DME groups based on optical coherence tomography findings. Serial changes in best-corrected visual acuity (BCVA), central subfoveal thickness (CST), and treatment and examination patterns were recorded at baseline and follow-up visits (6, 12, 18, and 24 months), and analyzed using linear mixed models and paired t-tests.Results: A total of 209 participants (81 female patients, 38.8%; mean age, 60.2 \u00b1 10.8 years) were enrolled. Over 24 months, 10 of 68 non-CI-DME patients (14.7%) developed CI-DME. CST significantly decreased in the CI-DME group (from 419 \u00b5m at baseline to 343 \u00b5m, &lt;i&gt;p&lt;\/i&gt; = 0.001), whereas BCVA remained unchanged in both groups. Throughout the 2-year period, the average number of anti\u2013vascular endothelial growth factor (anti-VEGF) injections was 3.1 \u00b1 3.6, while steroid injections averaged 0.7 \u00b1 1.5. The CI-DME group received significantly more anti-VEGF injections compared to the non-CI-DME group (3.8 \u00b1 3.9 vs. 2.0 \u00b1 2.8, &lt;i&gt;p&lt;\/i&gt; = 0.004). Additionally, the CI-DME group had more frequent visits (15.8 vs. 11.3, &lt;i&gt;p&lt;\/i&gt; = 0.017) and optical coherence tomography examinations (9.7 vs. 7.4, &lt;i&gt;p&lt;\/i&gt; = 0.023). The number of anti-VEGF injections decreased in the CI-DME group over time, while the number of visits decreased in both groups.Conclusions: In real-world clinical practice in Korea, the treatment and monitoring frequency for DME was lower than in major clinical trials, potentially contributing to suboptimal visual outcomes.<\/jats:p>","DOI":"10.3341\/kjo.2025.0057","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T07:51:12Z","timestamp":1754985072000},"page":"399-409","update-policy":"https:\/\/doi.org\/10.3341\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment Trends of Diabetic Macular Edema in Korea (TRACK) Study: A Prospective Multicenter Study"],"prefix":"10.3341","volume":"39","author":[{"given":"Min 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