{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:57:19Z","timestamp":1789077439725,"version":"build-2803163510"},"reference-count":31,"publisher":"Korean Ophthalmological Society","issue":"5","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ekjo.org"],"crossmark-restriction":true},"short-container-title":["Korean J Ophthalmol"],"published-print":{"date-parts":[[2025,10,5]]},"abstract":"Purpose: To evaluate and compare the short-term outcomes of an accelerated corneal cross-linking (CXL) protocol with a total energy dose of 7.2 J\/cm<sup>2<\/sup> in pediatric and adult keratoconus patients.Methods: This study included 113 eyes of 82 keratoconus patients who underwent accelerated epithelium-off CXL (12 mW\/cm<sup>2<\/sup> for 10 minutes) at a university hospital. Patients were divided into two groups based on age: <18 years (group 1, 48 eyes; mean age, 15.4 \u00b1 1.6 years) and \u226518 years (group 2, 65 eyes; mean age, 23.4 \u00b1 3.4 years). Preoperative and postoperative (6-month) uncorrected visual acuity, best-corrected visual acuity, keratometric indices, central corneal thickness, and endothelial cell density were analyzed and compared between groups.Results: Significant improvements in best-corrected visual acuity and reductions in keratometric indices were observed in both groups (<i>p<\/i> < 0.05). While both groups demonstrated significant visual and structural improvements, group 2 exhibited a greater magnitude of change in most keratometric and refractive parameters. Both groups exhibited significant decreases in central corneal thickness (<i>p<\/i> < 0.001). Posterior keratometric values showed statistically significant changes in both groups (<i>p<\/i> < 0.001). Endothelial cell density remained stable, and no severe complications were noted.Conclusions: Accelerated CXL with a total energy dose of 7.2 J\/cm<sup>2<\/sup> demonstrated a favorable safety profile and significant efficacy in stabilizing keratoconus in both pediatric and adult patients over a 6-month period. Notably, adult patients exhibited a greater extent of keratometric and refractive improvement, suggesting a potentially age-dependent biomechanical response. These findings support the utility of this protocol as an early intervention strategy, particularly in young adults with progressive disease.<\/jats:p>","DOI":"10.3341\/kjo.2025.0066","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T04:57:34Z","timestamp":1755147454000},"page":"432-440","update-policy":"https:\/\/doi.org\/10.3341\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of 7.2 J\/cm2 Accelerated Corneal Cross-Linking in Pediatric and Adult Keratoconus: A Comparative 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