{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:44:09Z","timestamp":1781833449669,"version":"3.54.5"},"reference-count":36,"publisher":"Korean Ophthalmological Society","issue":"5","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016275","name":"Seoul National University Bundang Hospital","doi-asserted-by":"publisher","award":["02-2020-0005"],"award-info":[{"award-number":["02-2020-0005"]}],"id":[{"id":"10.13039\/100016275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ekjo.org"],"crossmark-restriction":true},"short-container-title":["Korean J Ophthalmol"],"published-print":{"date-parts":[[2025,10,5]]},"abstract":"<jats:p>Purpose: Although numerous studies have investigated the progression of myopia, a reliable animal model for hyperopia remains undeveloped. This study aimed to evaluate whether blue light exposure can suppress emmetropization in a manner comparable to lens-induced hyperopia, thereby facilitating the development of an experimental animal model of hyperopia.Methods: Five-day-old 24 guinea pigs were randomly assigned to four different experimental groups based on light exposure conditions. They were housed under a 12-hour light\/dark cycle (lights on at 8 AM and off at 8 PM) and exposed to either white light (control) or blue light (460 \u00b1 20 nm). To induce hyperopia, a custom-designed +10 diopters (D) lens was fabricated using a three-dimensional printer and securely attached to randomly selected one eye with hook-and-loop fasteners and tissue adhesive. Refractive errors, corneal curvature, and axial length were measured using streak retinoscopy and A-scan ultrasound, with repeated measurements to assess intereye deviation.Results: At the end of the treatment period of 6 weeks, guinea pigs reared under blue light with an attached +10 D lens exhibited a significantly greater hyperopic shift compared to those reared under blue light without the lens. In contrast, guinea pigs raised under white light underwent emmetropization regardless of +10 D lens attachment.Conclusions: Blue light exposure significantly suppressed emmetropization by inducing a marked hyperopic shift in guinea pigs, whereas white light conditions support normal emmetropization regardless of lens attachment. These findings suggest that blue light plays a crucial role in hyperopia induction and can be effectively utilized to establish a stable hyperopia animal model.<\/jats:p>","DOI":"10.3341\/kjo.2025.0100","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T07:51:12Z","timestamp":1754985072000},"page":"410-417","update-policy":"https:\/\/doi.org\/10.3341\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of a Hyperopia Animal Model Using Blue Light in Guinea Pigs"],"prefix":"10.3341","volume":"39","author":[{"given":"Yung 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