{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:36:04Z","timestamp":1783942564927,"version":"3.55.0"},"reference-count":20,"publisher":"Korean Ophthalmological Society","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ekjo.org"],"crossmark-restriction":true},"short-container-title":["Korean J Ophthalmol"],"published-print":{"date-parts":[[2026,6,5]]},"abstract":"<jats:p>Purpose: To evaluate systemic oxidative stress by comparing serum 8-hydroxy-2\u2032-deoxyguanosine (8-OHdG), coenzyme Q10 (CoQ10), malondialdehyde (MDA), and 25-hydroxyvitamin D (25(OH)D) levels between primary open-angle glaucoma (POAG) patients and healthy controls.Methods: This prospective case-control study included 37 POAG patients and 35 age-matched controls. Serum levels were measured via enzyme-linked immunosorbent assay. Nonparametric tests (Mann-Whitney U-test and Spearman correlations) and multivariate linear regression adjusting for age and sex were used.Results: POAG patients showed significantly higher MDA (3.01 vs. 2.46 nmol\/mL, p = 0.021) and 8-OHdG (9.34 vs. 6.52 ng\/mL, p &lt; 0.001), but lower CoQ10 (7.28 vs. 8.98 ng\/mL, p &lt; 0.001) and 25(OH)D (15.02 vs. 17.45 ng\/mL, p = 0.013). MDA and 8-OHdG showed a strong positive correlation (rho = 0.855, p &lt; 0.001). CoQ10 and 8-OHdG showed a moderate positive correlation (rho = 0.466, p = 0.004). No significant correlation was found between 25(OH)D and 8-OHdG (rho = \u20130.118, p = 0.488). After adjusting for age and sex, POAG remained independently associated with lower CoQ10 (p &lt; 0.001). No oxidative marker correlated with intraocular pressure, visual field mean deviation, or retinal nerve fiber layer thickness in POAG patients (all p &gt; 0.05).Conclusions: POAG patients exhibit systemic oxidative imbalance with elevated oxidative damage and reduced antioxidant capacity. The positive CoQ10\u20138-OHdG correlation may suggest a compensatory relationship. This imbalance is associated with POAG but does not correlate with clinical severity cross-sectionally, suggesting it reflects a systemic disease component rather than a direct severity marker.<\/jats:p>","DOI":"10.3341\/kjo.2025.0130","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:06:37Z","timestamp":1773201997000},"page":"308-314","update-policy":"https:\/\/doi.org\/10.3341\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oxidative DNA Damage and Antioxidant Depletion: A Systemic Profile in Primary Open-Angle Glaucoma"],"prefix":"10.3341","volume":"40","author":[{"given":"Kubra","family":"Akyol","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kahramankazan State Hospital, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Kocer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ataturk University Research Hospital, Erzurum, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil \u0130brahim","family":"Ozkan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Bal\u0131kesir University School of Medicine, Bal\u0131kesir, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1893","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1609-2"},{"key":"ref2","volume-title":"Open angle glaucoma","author":"Tripathy"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/09286580600681339"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.06.001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2011.584370"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1021\/tx00050a007"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.341"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.05.011"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1212"},{"key":"ref10","first-page":"292","volume-title":"Role of oxidative stress in patients with primary open angle glaucoma and senile cataract","author":"Ocakoglu","year":"2008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701565"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(03)00114-1"},{"key":"ref13","volume-title":"","author":"Mumcu","year":"2011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.06.004"},{"key":"ref15","first-page":"438","volume-title":"Association of severity of primary open-angle glaucoma with serum vitamin D levels in patients of African descent","author":"Ayyagari","year":"2019"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.10.022"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02455.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2656"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.244781"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.529"}],"container-title":["Korean Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ekjo.org\/upload\/pdf\/kjo-2025-0130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ekjo.org\/journal\/view.php?doi=10.3341\/kjo.2025.0130","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ekjo.org\/upload\/pdf\/kjo-2025-0130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:16:38Z","timestamp":1781511398000},"score":1,"resource":{"primary":{"URL":"http:\/\/ekjo.org\/journal\/view.php?doi=10.3341\/kjo.2025.0130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"URL":"https:\/\/doi.org\/10.3341\/kjo.2025.0130","relation":{},"ISSN":["1011-8942","2092-9382"],"issn-type":[{"value":"1011-8942","type":"print"},{"value":"2092-9382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]},"assertion":[{"value":"2025-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}