{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:40:34Z","timestamp":1781091634614,"version":"3.54.1"},"reference-count":30,"publisher":"Annals of Laboratory Medicine","issue":"4","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270826"],"award-info":[{"award-number":["82270826"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200874"],"award-info":[{"award-number":["82200874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170802"],"award-info":[{"award-number":["82170802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070816"],"award-info":[{"award-number":["82070816"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870537"],"award-info":[{"award-number":["81870537"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["20161318"],"award-info":[{"award-number":["20161318"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Minhang District","award":["2021MHZ085"],"award-info":[{"award-number":["2021MHZ085"]}]}],"content-domain":{"domain":["annlabmed.org"],"crossmark-restriction":true},"short-container-title":["Ann Lab Med"],"published-print":{"date-parts":[[2024,7,1]]},"DOI":"10.3343\/alm.2023.0337","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T07:50:35Z","timestamp":1709538635000},"page":"343-353","update-policy":"https:\/\/doi.org\/10.3343\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>TSHR<\/i> Variant Screening and Phenotype Analysis in 367 Chinese Patients With Congenital Hypothyroidism"],"prefix":"10.3343","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9853-168X","authenticated-orcid":false,"given":"Hai-Yang","family":"Zhang","sequence":"first","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3256-1270","authenticated-orcid":false,"given":"Feng-Yao","family":"Wu","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5679-3724","authenticated-orcid":false,"given":"Xue-Song","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrine Metabolism, Minhang Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5740-7241","authenticated-orcid":false,"given":"Ping-Hui","family":"Tu","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-0225","authenticated-orcid":false,"given":"Cao-Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1890-0409","authenticated-orcid":false,"given":"Rui-Meng","family":"Yang","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0599-9434","authenticated-orcid":false,"given":"Ren-Jie","family":"Cui","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2428-8922","authenticated-orcid":false,"given":"Chen-Yang","family":"Wu","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-1586","authenticated-orcid":false,"given":"Ya","family":"Fang","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6409-5202","authenticated-orcid":false,"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9609-5803","authenticated-orcid":false,"given":"Huai-Dong","family":"Song","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-9541","authenticated-orcid":false,"given":"Shuang-Xia","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27150","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0333"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-020-00267-x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02646-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0112"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0070"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30380"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.01.008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.6.8536"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.27"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2017.03.004"},{"key":"ref11","unstructured":"Cassio A, Nicoletti A, Rizzello A, Zazzetta E, Bal M, Baldazzi L. Current loss-of-function mutations in the thyrotropin receptor gene: when to investigate, clinical effects, and treatment. J Clin Res Pediatr Endocrinol 2013;5 Suppl 1:29-39."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320305"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.07.031"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-1017"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-021-01237-3"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1891"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/cge.14065"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.09.007"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11078"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.02.009"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.5005\/jp\/books\/13094_9"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0618"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1767"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2010.209"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.01967.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-0153"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)45312-9"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.27.123"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9372"}],"container-title":["Annals of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/ALM\/2024\/044\/ALM044-04-343.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/pdf.medrang.co.kr\/ALM\/2024\/044\/ALM044-04-343.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T08:21:41Z","timestamp":1711354901000},"score":1,"resource":{"primary":{"URL":"http:\/\/annlabmed.org\/journal\/view.html?doi=10.3343\/alm.2023.0337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7,1]]}},"alternative-id":["10.3343\/alm.2023.0337"],"URL":"https:\/\/doi.org\/10.3343\/alm.2023.0337","relation":{},"ISSN":["2234-3806","2234-3814"],"issn-type":[{"value":"2234-3806","type":"print"},{"value":"2234-3814","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,4]]},"assertion":[{"value":"http:\/\/annlabmed.org\/journal\/view.html?doi=10.3343\/alm.2023.0337","URL":"http:\/\/annlabmed.org\/journal\/view.html?doi=10.3343\/alm.2023.0337","name":"the_journal","label":"Ann Lab Med","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2023-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-04","order":3,"name":"published","label":"Online First","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-01","order":4,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2024 The Korean Society for Laboratory Medicine","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}