{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:36:04Z","timestamp":1781274964519,"version":"3.54.1"},"reference-count":39,"publisher":"Annals of Laboratory Medicine","issue":"2","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2024IL0024"],"award-info":[{"award-number":["2024IL0024"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annlabmed.org"],"crossmark-restriction":true},"short-container-title":["Ann Lab Med"],"published-print":{"date-parts":[[2026,3,1]]},"DOI":"10.3343\/alm.2025.0274","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T07:48:01Z","timestamp":1759218481000},"page":"136-145","update-policy":"https:\/\/doi.org\/10.3343\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clonal Burden, Immunoglobulin Heavy Chain Variable Gene Somatic Hypermutations, and Immunoglobulin Gene Repertoire in Korean Patients with Chronic Lymphocytic Leukemia Assessed by Next-generation Sequencing"],"prefix":"10.3343","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1422-4964","authenticated-orcid":false,"given":"Taegeun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Dongguk University Ilsan Hospital, Goyang, Korea"},{"name":"Department of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-8740","authenticated-orcid":false,"given":"Daehyun","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea"},{"name":"Department of Laboratory Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-5044","authenticated-orcid":false,"given":"Miyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea"},{"name":"Department of Laboratory Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4403-8989","authenticated-orcid":false,"given":"Young-Uk","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea"},{"name":"Department of Laboratory Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3201-5728","authenticated-orcid":false,"given":"Sang-Hyun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea"},{"name":"Department of Laboratory Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3127-0068","authenticated-orcid":false,"given":"Jung-Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8289-3548","authenticated-orcid":false,"given":"Dok Hyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4307-2795","authenticated-orcid":false,"given":"Hyungwoo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0045-1747","authenticated-orcid":false,"given":"Seongsoo","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea"},{"name":"Department of Laboratory Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27150","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"ref1","unstructured":"Naresh KN, Akinola NO, et al. Chronic lymphocytic leukaemia\/small lymphocytic lymphoma. In: Akkari Y, Alaggio R, et al, eds. WHO classification of tumours haematolymphoid tumours part B. 5th ed. Lyon: International Agency for Research on Cancer (International Arctic Research Center), 2024:368-77."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.0018"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30029-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01604-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184624"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253541"},{"key":"ref7","unstructured":"Invivoscribe technologies, Inc. Instructions for use LymphoTrack Dx IGHV leader somatic hypermutation assay - MiSeq. <a href=\"https:\/\/invivoscribe.com\/uploads\/products\/informationalDownloads\/280351.pdf\" target=\"_blank\">https:\/\/invivoscribe.com\/uploads\/products\/informationalDownloads\/280351.pdf<\/a> (updated on Feb 2017)."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2013.02.019"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01092.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000803"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.02.005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20987"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0818"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-012948"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21824"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12659"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2019.210"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043177"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-013-1286-z"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.12.001"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.074"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.12.021"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2023.43.4.323"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2023.43.4.328"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2023.0412"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-022-00300-2"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43171-9"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15205064"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001077"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2023.0298"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2016.10.002"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0132"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093\/nargab\/lqab019"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/nature14666"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2023.02.005"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24808"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040544"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1511"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02499-x"}],"container-title":["Annals of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/ALM\/2026\/046\/ALM046-02-136.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/pdf.medrang.co.kr\/ALM\/2026\/046\/ALM046-02-136.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T02:12:20Z","timestamp":1770603140000},"score":1,"resource":{"primary":{"URL":"http:\/\/annlabmed.org\/journal\/view.html?doi=10.3343\/alm.2025.0274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,1]]}},"alternative-id":["10.3343\/alm.2025.0274"],"URL":"https:\/\/doi.org\/10.3343\/alm.2025.0274","relation":{},"ISSN":["2234-3806","2234-3814"],"issn-type":[{"value":"2234-3806","type":"print"},{"value":"2234-3814","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"http:\/\/annlabmed.org\/journal\/view.html?doi=10.3343\/alm.2025.0274","URL":"http:\/\/annlabmed.org\/journal\/view.html?doi=10.3343\/alm.2025.0274","name":"the_journal","label":"Ann Lab Med","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2025-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":3,"name":"published","label":"Online First","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-01","order":4,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2026 The Korean Society for Laboratory Medicine","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}