{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T02:39:18Z","timestamp":1782355158037,"version":"3.54.5"},"reference-count":39,"publisher":"Korean Pediatric Society","issue":"4","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-cep.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pediatr"],"published-print":{"date-parts":[[2021,4,15]]},"abstract":"<jats:p>Background: Severe perinatal asphyxia results in multiple organ involvement, neonate hospitalization, and eventual death.Purpose: This study aimed to investigate the predictive factors of death in newborns with hypoxic-ischemic encephalopathy (HIE) receiving selective head cooling.Methods: This cross-sectional descriptive-retrospective study was conducted from 2013 to 2018 in Fatemieh Hospital of Hamadan and included 51 newborns who were admitted to the neonatal intensive care unit with a diagnosis of HIE. Selective head cooling for patients with moderate to severe HIE began within 6 hours of birth and continued for 72 hours. The required data for the predictive factors of death were extracted from the patients\u2019 medical files, recorded on a premade form, and analyzed using SPSS ver. 16.Results: Of the 51 neonates with moderate to severe HIE who were treated with selective head cooling, 16 (31%) died. There were significant relationships between death and the need for advanced neonatal resuscitation (P=0.002), need for mechanical ventilation (P=0.016), 1-minute Apgar score (P=0.040), and severely abnormal amplitude-integrated electroencephalography (a-EEG) (P=0.047). Multiple regression of variables or data showed that the need for advanced neonatal resuscitation was an independent predictive factor of death (P=0.0075) and severely abnormal a-EEG was an independent predictive factor of asphyxia severity (P=0.0001).Conclusion: All cases of neonatal death in our study were severe HIE (stage 3). Advanced neonatal resuscitation was an independent predictor of death, while a severely abnormal a-EEG was an independent predictor of asphyxia severity in infants with HIE.<\/jats:p>","DOI":"10.3345\/cep.2019.01382","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T07:56:27Z","timestamp":1598514987000},"page":"180-187","update-policy":"https:\/\/doi.org\/10.3345\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Predictive factors of death in neonates with hypoxic-ischemic encephalopathy receiving selective head cooling"],"prefix":"10.3345","volume":"64","author":[{"given":"Behnaz","family":"Basiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadkazem","family":"Sabzehei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4640-226X","authenticated-orcid":true,"given":"Mohammadmahdi","family":"sabahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1897","reference":[{"key":"ref1","volume-title":"","author":"Gillam-Krakauer","year":"2020"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000348823"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd003311"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.08.004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v5.i1.67"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2015.07.008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2018.09.001"},{"key":"ref9","first-page":"299","volume-title":"Early 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