{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T17:03:50Z","timestamp":1784653430991,"version":"3.55.0"},"reference-count":40,"publisher":"Korean Pediatric Society","issue":"4","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-cep.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pediatr"],"published-print":{"date-parts":[[2021,4,15]]},"abstract":"<jats:p>Background: Evidence shows that fluconazole prophylaxis is an effective treatment against invasive fungal infections in preterm neonates, however, the most efficient schedule of fluconazole prophylaxis for the colonization and mortality of invasive candidiasis (IC) is unknown. Purpose: This systematic review and meta-analysis aimed to assess the efficiency of different prophylactic fluconazole schedules in controlling IC colonization, infection, and mortality in very low birth weight (VLBW) and extremely low birth weight (ELBW) infants in neonatal intensive care units. Methods: We searched the PubMed, Scopus, Embase, and Cochrane databases using the keywords \u201ccandida,\u201d \u201cinvasive candidiasis,\u201d \u201cIC,\u201d \u201cfluconazole prophylaxis,\u201d \u201cpreterm infants,\u201d \u201cvery low birth weight infants,\u201d \u201cVLBW,\u201d \u201cextremely low birth weight,\u201d and \u201cELBW.\u201d Results: Mortality was significantly decreased in a meta-analysis of studies using different fluconazole prophylaxis regimens. The meta-analysis also indicated a significant decrease in the incidence of IC-associated mortality in ELBW infants using the same fluconazole prophylaxis schedules. Conclusion: Future studies should explore the effectiveness of other different fluconazole prophylaxis schedules on IC colonization, infection, and mortality.<\/jats:p>","DOI":"10.3345\/cep.2019.01431","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T06:22:17Z","timestamp":1589437337000},"page":"172-179","update-policy":"https:\/\/doi.org\/10.3345\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Fluconazole prophylaxis against invasive candidiasis in very low and extremely low birth weight preterm neonates: a systematic review and meta-analysis"],"prefix":"10.3345","volume":"64","author":[{"given":"Mahmoud","family":"Robati Anaraki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Nouri-Vaskeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5897-7883","authenticated-orcid":true,"given":"Shahram","family":"Abdoli Oskoei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1897","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2292"},{"key":"ref2","first-page":"66","volume-title":"Prevalence at birth of cleft lip with or without cleft palate: data from the International Perinatal Database of Typical Oral Clefts (IPDTOC)","year":"2011"},{"key":"ref3","first-page":"S27","volume-title":"Systemic fungal infections in neonates","author":"Rao","year":"2005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03288.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182863a1c"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1586\/eri.12.74"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-015-0238-x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010494"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.2.293"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065733"},{"key":"ref11","first-page":"830","volume-title":"Fluconazole prophylaxis against fungal colonization and invasive fungal infection in very low birth weight infants","author":"Parikh","year":"2007"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1130"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.11.002"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200006000-00002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-016-0605-y"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1645-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.03.036"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.02.039"},{"key":"ref19","volume-title":"","author":"Dorland","year":"2011"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-45"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.15296\/ijwhr.2015.44"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211570"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.04.016"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211914"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/inf.0b013e3181e9dea2"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.178996"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.02.020"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2227"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.2624"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1013933"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"ref33","first-page":"38","volume-title":"ESCMID* guideline for the diagnosis and management of Candida diseases 2012: prevention and management of invasive infections in neonates and children caused by Candida spp","author":"Hope","year":"2012"},{"key":"ref34","first-page":"158","volume-title":"Recommendations for the management of candidemia in neonates in Latin America. Latin America Invasive Mycosis Network","author":"Santolaya","year":"2013"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2010.12.012"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3412"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd003850.pub5"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2017.01.008"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2012.02543.x"}],"container-title":["Clinical and Experimental Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.e-cep.org\/upload\/pdf\/cep-2019-01431.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.e-cep.org\/journal\/view.php?doi=10.3345\/cep.2019.01431","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.e-cep.org\/upload\/pdf\/cep-2019-01431.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T04:10:04Z","timestamp":1617250204000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.e-cep.org\/journal\/view.php?doi=10.3345\/cep.2019.01431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"URL":"https:\/\/doi.org\/10.3345\/cep.2019.01431","relation":{},"ISSN":["2713-4148"],"issn-type":[{"value":"2713-4148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,15]]},"assertion":[{"value":"2019-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-14","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}