{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:07:48Z","timestamp":1787026068478,"version":"build-2736575974"},"reference-count":29,"publisher":"Korean Pediatric Society","issue":"10","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"ICMR MD\/MS Thesis Research Grant","award":["MD20JUN-0083"],"award-info":[{"award-number":["MD20JUN-0083"]}]},{"name":"Manipal Research grant"}],"content-domain":{"domain":["e-cep.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pediatr"],"published-print":{"date-parts":[[2022,10,15]]},"abstract":"<jats:p>Background: Changes in maternal weight affect the maternal and fetal hypothalamic-pituitary-adrenal axis, influencing birth weight and contributing to the fetal origin of adult diseases (Barker\u2019s hypothesis). This study primarily focused on cord blood cortisol levels and identified the association between maternal prepregnancy body mass index (pre-BMI) and birth weight. It also assessed cord blood lipid profile changes related to maternal pre-BMI, birth weight, and cord blood cortisol levels.Purpose: To study the mediation effect of cord blood cortisol level between maternal pre-BMI and birth weight and its correlation with cord blood lipid profile.Methods: A total of 169 maternal-neonatal pairs were included at 2 tertiary care centers. Mediation analysis was used to estimate the extent of the association between maternal weight changes and birth weight.Results: For each unit increase in maternal pre-BMI, birth weight increased by 90.5 g; for every kilogram increase in gestational weight, birth weight increased by 128.44 g. No considerable mediation effect of cortisol was found between pre-BMI and gestational weight gain or between rate of weight gain and birth weight. Pre-BMI and birth weight had a significant negative correlation with high-density lipoprotein cholesterol (HDL-C) levels, i.e., HDL-C was decreased by 1.1 mg\/dL for every unit increase in BMI (P=0.017) and for every 100-g increase in birth weight, HDL-C decreased by 0.6 mg\/dL (P=0.046). A significant positive correlation was found between cord blood lipid profile and cortisol levels, especially HDL-C (P=0.041).Conclusion: Cord blood cortisol levels did not mediate the association between maternal weight change and birth weight. A positive correlation was noted between cord blood cortisol levels and HDL-C level. Cord blood HDL-C level was negatively correlated with maternal pre-BMI and birth weight.<\/jats:p>","DOI":"10.3345\/cep.2022.00122","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T20:46:38Z","timestamp":1659041198000},"page":"500-506","update-policy":"https:\/\/doi.org\/10.3345\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mediation effect of cord blood cortisol levels between maternal prepregnancy body mass index and birth weight: a hospital-based cross-sectional study"],"prefix":"10.3345","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7616-160X","authenticated-orcid":true,"given":"Nisanth","family":"Selvam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3931-5360","authenticated-orcid":true,"given":"Jayashree","family":"K","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7153-411X","authenticated-orcid":true,"given":"Prasanna","family":"Mithra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1897","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.11.043"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7555\/jbr.26.20120037"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135641"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.6.1235"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-03071-y"},{"key":"ref6","first-page":"170","volume-title":"The impact of maternal obesity on maternal and fetal health","author":"Leddy","year":"2008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1128-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10266-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.09.019"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030978"},{"key":"ref11","first-page":"15","volume-title":"Corticosteroids-mechanisms of action in health and disease","author":"Ramamoorthy","year":"2016"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22524"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00073"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.32677\/ijch.2018.v05.i09.010"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57373-z"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pepo.2013.08.004"},{"key":"ref17","volume-title":"","year":"2000"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(05)82056-6"},{"key":"ref19","first-page":"210","volume-title":"Weight gain during pregnancy. Committee Opinion No. 548","year":"2013"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1542\/peds.37.3.403"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1515\/cclm.2001.068"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2249-z"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.11606\/s1518-8787.2018052000125"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s40608-018-0194-4"},{"key":"ref25","first-page":"1396","volume-title":"Lifestyle interventions limit gestational weight gain in women with overweight or obesity: LIFE-Moms prospective meta-analysis Alan","author":"Peaceman","year":"2018"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/65854"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2007.00870.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.33.6.1364"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000116692.85043.ef"}],"container-title":["Clinical and Experimental Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-cep.org\/upload\/pdf\/cep-2022-00122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-cep.org\/journal\/view.php?doi=10.3345\/cep.2022.00122","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-cep.org\/upload\/pdf\/cep-2022-00122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T21:38:58Z","timestamp":1664833138000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-cep.org\/journal\/view.php?doi=10.3345\/cep.2022.00122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,15]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"URL":"https:\/\/doi.org\/10.3345\/cep.2022.00122","relation":{},"ISSN":["2713-4148"],"issn-type":[{"value":"2713-4148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,15]]},"assertion":[{"value":"2022-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-29","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}