{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:58:20Z","timestamp":1768791500908,"version":"3.49.0"},"reference-count":27,"publisher":"Korean Pediatric Society","issue":"5","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-cep.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pediatr"],"published-print":{"date-parts":[[2024,5,15]]},"abstract":"<jats:p>Background: The effect of vitamin E supplementation on bilirubin levels in infants was previously explored, but the results were inconclusive.Purpose: To examine the effect of vitamin E supplementation on bilirubin levels in term infants in the neonatal intensive care unit (NICU).Methods: This interventional double-blind randomized clinical trial was conducted in the Sanandaj Besat Hospital NICU. Enrolled newborns were between 37 and 42 weeks and 6 days of gestation and required phototherapy according to American Academy of Pediatrics clinical guidelines. A total of 138 infants were randomly assigned to vitamin E (n=68) or placebo (n=70) groups. In addition to phototherapy, the vitamin E group received 0.5 mL (5 IU) of supplemental vitamin E daily, whereas the placebo group received 0.5 mL of oral dextrose daily. STATA 17 was used for the data analysis.Results: Changes in bilirubin levels at 24 hours postintervention did not differ significantly from baseline in either group. Vitamin E supplementation did not significantly reduce total bilirubin levels at 24 hours postintervention (mean difference [MD], -0.18; P=0.204; 95% confidence interval [CI], -1.39 to 1.02). However, the vitamin E group exhibited lower total bilirubin levels than the placebo group at 48 hours postintervention (MD, 0.18; P=0.365; 95% CI, -0.89 to 1.27) and 72 hours (MD, 0.36; P=0.356; 95% CI, -2.34 to 1.61), although the differences were not statistically significant. A subgroup analysis revealed that female infants experienced a greater reduction in total bilirubin levels than male infants.Conclusion: Infants administered vitamin E versus placebo demonstrated similar reductions in bilirubin levels and hospital stays. Although the average bilirubin changes did not differ significantly between groups, the vitamin E group showed a more noticeable reduction over time, indicating a positive effect of vitamin E supplementation on serum bilirubin reduction.Trial registration: IRCT20220806055625N2 (registered December 26, 2022; http:\/\/irct.ir\/trial\/67135).<\/jats:p>","DOI":"10.3345\/cep.2023.01312","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T01:23:36Z","timestamp":1711416216000},"page":"249-256","update-policy":"https:\/\/doi.org\/10.3345\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of vitamin E supplementation on bilirubin levels in infants with hyperbilirubinemia: a double-blind randomized clinical trial"],"prefix":"10.3345","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3629-4570","authenticated-orcid":true,"given":"Mojtaba","family":"Cheraghi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8491-427X","authenticated-orcid":true,"given":"Maziar","family":"Nikouei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0619-7364","authenticated-orcid":true,"given":"Majid","family":"Mansouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0068-6156","authenticated-orcid":true,"given":"Siros","family":"Hemmatpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-5930","authenticated-orcid":true,"given":"Yousef","family":"Moradi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1897","reference":[{"key":"ref1","first-page":"873","volume-title":"Evaluation and treatment of neonatal hyperbilirubinemia","author":"Muchowski","year":"2014"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542\/pir.32.8.341"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.21608\/anj.2020.69366"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2018.08.006"},{"key":"ref5","first-page":"Doc03","volume-title":"Antioxidant vitamins and hyperbilirubinemia in neonates","author":"Abdul-Razzak","year":"2007"},{"key":"ref6","first-page":"E4","volume-title":"Neonatal hyperbilirubinemia: an evidence-based approach","author":"Pace","year":"2019"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.212"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0395"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.e130"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1494"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-4160-4_43"},{"key":"ref12","first-page":"58","volume-title":"El alfatocoferol y el acido alfa-lipoico. Una sinergia antioxidante con potencial en medicina preventiva Alpha-tocopherol and alpha-lipoic acid. 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