{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:14:40Z","timestamp":1790295280976,"version":"4.1.0"},"reference-count":30,"publisher":"Korean Pediatric Society","issue":"9","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004697","name":"Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["code140102271363"],"award-info":[{"award-number":["code140102271363"]}],"id":[{"id":"10.13039\/501100004697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-cep.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pediatr"],"published-print":{"date-parts":[[2024,9,15]]},"abstract":"<jats:p>Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by severe social communication deficits and stereotypical repetitive behaviors.Purpose: This umbrella review assessed neonatal risk factors associated with ASD using meta-analyses and systematic reviews.Methods: We conducted a systematic search of interna- tional databases including PubMed, Scopus, and Web of Science for studies published through April 2022 utilizing pertinent keywords. A random-e\ufb00ects model was used to calculate the odds ratio (OR) and 95% confidence interval (CI). Substantial heterogeneity was considered at values of I2\u226550%. A quality assessment of the included studies was performed using the A MeaSurement Tool to Assess Systematic Reviews (AMSTAR2) checklist.Results: A total of 207,221 children with ASD and22,993,128 neurotypical children were included. Six meta- analyses were included in this umbrella review. The factors of congenital heart disease (OR, 1.35; 95% CI, 1.17\u20131.52),macrosomia (OR, 1.11; 95% CI, 1.05\u20131.18), low birth weight (OR, 1.63; 95% CI, 1.48\u20131.81), very low birth weight (OR, 2.25; 95% CI, 1.79\u20132.83), small for gestational age (OR,1.17; 95% CI, 1.09\u20131.24), jaundice (OR, 1.74; 95% CI, 1.42\u20132.12), male sex (OR, 1.47; 95% CI, 1.39\u20131.55) and 1-minuteApgar score &lt;7 (OR, 1.40; 95% CI, 1.26\u20131.55) were graded as suggestive evidence (class III). Only 3 studies reported heterogeneity (I2&lt;50%). Based on the AMSTAR2 analysis, the methodological quality was critically low in 3 meta- analyses, low in 2, and moderate in 1.Conclusion: Based on these results, clinicians should consider the risk factors for ASD and screen children in clinics.<\/jats:p>","DOI":"10.3345\/cep.2024.00136","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:49:34Z","timestamp":1721350174000},"page":"459-464","update-policy":"https:\/\/doi.org\/10.3345\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neonatal risk factors associated with autism spectrum disorders: an umbrella review"],"prefix":"10.3345","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1724-6432","authenticated-orcid":true,"given":"Amir Mohammad","family":"Salehi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8829-9304","authenticated-orcid":true,"given":"Erfan","family":"Ayubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5918-2310","authenticated-orcid":true,"given":"Salman","family":"Khazaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-0814","authenticated-orcid":true,"given":"Ensiyeh","family":"Jenabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-087X","authenticated-orcid":true,"given":"Saeid","family":"Bashirian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5125-9512","authenticated-orcid":true,"given":"Zohreh","family":"Salimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1897","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.044"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1408133"},{"key":"ref3","first-page":"1","volume-title":"Prevalence and characteristics of autism spectrum disorder among children aged 8 years - 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