{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:42:18Z","timestamp":1782931338300,"version":"3.54.5"},"reference-count":25,"publisher":"Korean Pediatric Society","issue":"1","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-cep.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pediatr"],"published-print":{"date-parts":[[2025,1,15]]},"abstract":"<jats:p>Background: Central precocious puberty (CPP) is typically treated with gonadotropin-releasing hormone (GnRH) agonists. Although numerous GnRH agonist variants are available, limited research has compared the efficacy of leuprolide acetate and triptorelin pamoate administered at 3-month intervals.Purpose: This study aimed to assess the efficacy of CPP treatment with triptorelin pamoate and leuprolide acetate administered at 3-month intervals.Methods: This retrospective cohort study included 116 girls with CPP: 71 treated with leuprolide acetate every 3 months and 45 treated with triptorelin pamoate every 3 months. Anthropometric measurements were compared before and after therapy. At 6 months after the therapy, luteinizing hormone (LH) suppression was evaluated.Results: When administered every 3 months, leuprolide acetate and triptorelin pamoate significantly suppressed LH. The predicted adult height (PAH) and degree of bone age advancement at the end of treatment were comparable.Conclusion: Treatment with leuprolide acetate and triptorelin pamoate every 3 months did not have significantly different effects on LH suppression or PAH.<\/jats:p>","DOI":"10.3345\/cep.2024.00822","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T07:43:51Z","timestamp":1730879031000},"page":"91-96","update-policy":"https:\/\/doi.org\/10.3345\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of leuprolide acetate versus triptorelin pamoate administered every 3 months for treatment of central precocious 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of central precocious puberty with triptorelin 11.25 mg depot formulation","author":"Mart\u00ednez-Aguayo","year":"2006"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/583751"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2021.36.e219"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-023-02617-8"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2040134.067"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1043293"}],"container-title":["Clinical and Experimental 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