{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:14:01Z","timestamp":1777709641610,"version":"3.51.4"},"reference-count":35,"publisher":"Korean Pediatric Society","issue":"10","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-cep.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pediatr"],"published-print":{"date-parts":[[2025,10,15]]},"abstract":"<jats:p>Background: Helicobacter pylori infection is a common gastrointestinal pathogen associated with gastritis and peptic ulcers. The early detection of H. pylori-related gastritis is crucial to its effective management, especially in pediatric patients with dyspepsia.Purpose: This study aimed to assess the expression of miRNA-146a and miRNA-125b as potential indicators of H. pylori-associated gastritis in children.Methods: This cross-sectional study included 70 H. pylori-positive children and 50 H. pylori-negative controls aged \u226418 years with recurrent abdominal pain who underwent upper gastrointestinal endoscopy. The miRNA-146a and miRNA-125b expression levels in gastric biopsies were determined using quantitative reverse transcriptase\u2013polymerase chain reaction.Results: H. pylori-positive children had significantly higher levels of miRNA-146a than H. pylori-negative children across all endoscopic findings (range, 2.2\u20132.7 vs. 1.07\u20131.2; P&lt;0.001) and histologic grades of gastritis (range, 2.0\u20132.4 vs. 1.2\u20131.3; P&lt;0.001). Conversely, the H. pylori-positive group showed consistently lower miRNA-125b levels across all parameters (range, 0.3\u20130.8 vs. 0.4\u20130.9; P&lt;0.001). Both miRNAs differentiated H. pylori status with an area under the curve of &gt;0.95.Conclusion: The altered expression of miRNA-146a and miRNA-125b in gastric biopsies of H. pylori-positive children suggests their potential role as molecular markers of H. pylori-associated gastritis.<\/jats:p>","DOI":"10.3345\/cep.2025.00192","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T22:02:20Z","timestamp":1743458540000},"page":"781-789","update-policy":"https:\/\/doi.org\/10.3345\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Role of miRNA-146a and miRNA-125b in Helicobacter pylori"],"prefix":"10.3345","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7092-9216","authenticated-orcid":true,"given":"Nashwa Farouk","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-4933","authenticated-orcid":true,"given":"Ola 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