{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:04:11Z","timestamp":1792058651295,"version":"4.4.0"},"reference-count":25,"publisher":"Korean Pediatric Society","issue":"8","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-cep.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pediatr"],"published-print":{"date-parts":[[2025,8,15]]},"abstract":"<jats:p>Background: Liposomal iron, a novel oral formulation of ferric pyrophosphate that demonstrates improved gastrointestinal absorption and bioavailability with fewer side effects than conventional iron, represents a significant advancement in the treatment of iron-deficiency anemia (IDA).Purpose: To conduct an in-depth comparative study of liposomal SunActive and conventional iron supplements (iron polymaltose complex) for treating IDA in children aged 2\u201312 yearsMethods: This prospective randomized controlled trial included 192 children who visited the outpatient clinic of the Pediatric Department at Menoufia University Hospital and were diagnosed with IDA. The patients were divided into group 1, 96 pediatric patients receiving oral liposomal SunActive iron; and group 2, 96 pediatric patients treated with conventional oral iron (iron polymaltose complex).Results: After 1 month of oral iron therapy, group 1 exhibited higher hemoglobin, hematocrit, serum ferritin, and serum iron levels and greater transferrin saturation than group 2. After 6 months of oral iron therapy, hemoglobin level (P&lt;0.001), iron profile (P&lt;0.001), and growth-related anthropometric measurements were higher in group 1 versus group 2 (P&lt;0.001for z score for weight).Conclusion: Iron supplements effectively improve anthropometric measurements, complete blood count parameters, and iron profiles. However, orally administered liposomal SunActive iron exhibits better effects, reduced drug refusal rates, and improved compliance rates, thereby benefiting children's growth.<\/jats:p>","DOI":"10.3345\/cep.2025.00262","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T01:14:56Z","timestamp":1753060496000},"page":"608-615","update-policy":"https:\/\/doi.org\/10.3345\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Liposomal SunActive versus conventional iron for treatment of iron-deficiency anemia in children aged 2\u201312 years: a prospective randomized controlled trial"],"prefix":"10.3345","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-0572","authenticated-orcid":true,"given":"Wael A.","family":"Bahbah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin A.H.S.","family":"Younis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan Salama","family":"Elbelouny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2366-8009","authenticated-orcid":true,"given":"Asmaa 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iron oral salts","author":"Paz","year":"2016"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-020-01044-x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/ph16060847"},{"key":"ref23","first-page":"645","volume-title":"Effect of oral liposomal iron versus intravenous iron for treatment of iron deficiency anemia in CKD patients: a randomized trial","author":"Pisani","year":"2015"},{"key":"ref24","first-page":"34","volume-title":"Efficacy, tolerance and adherence to treatment with Sucrosomial\u00ae Iron in patients with chronic kidney disease stages 3-4 and iron deficiency","author":"Arenas","year":"2016"},{"key":"ref25","first-page":"30","volume-title":"Oral Sucrosomial\u00ae iron supplementation in patients affected by Hodgkin lymphoma with mild anemia before chemotherapy: an observational study","author":"Romano","year":"2016"}],"container-title":["Clinical and Experimental 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