{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T14:04:41Z","timestamp":1775570681683,"version":"3.50.1"},"reference-count":35,"publisher":"Korean Pediatric Society","issue":"1","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP17km0105001"],"award-info":[{"award-number":["JP17km0105001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21tm0124005"],"award-info":[{"award-number":["JP21tm0124005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21tm0424601"],"award-info":[{"award-number":["JP21tm0424601"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24gn0110088"],"award-info":[{"award-number":["JP24gn0110088"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JST SPRING","award":["JPMJSP2114"],"award-info":[{"award-number":["JPMJSP2114"]}]}],"content-domain":{"domain":["e-cep.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pediatr"],"published-print":{"date-parts":[[2026,1,15]]},"abstract":"<jats:p>Background: Associations have been suggested between prenatal exposure and allergic diseases in children as well as between respiratory allergies and maternal sleep disorders during pregnancy.Purpose: This study aimed to examine the association between maternal sleep disorders during pregnancy and allergic diseases, including respiratory, skin, and ocular allergies, in their children.Methods: This study was based on the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Sleep disorders during pregnancy were defined as an Athens Insomnia Scale score of \u22656. Allergic diseases in children up to 5 years of age were assessed by maternal self-report on \u201cbronchial asthma,\u201d \u201catopic dermatitis,\u201d \u201cfood allergy,\u201d and \u201callergic conjunctivitis\/allergic rhinitis\/hay fever.\u201d Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using a Cox proportional hazards model.Results: A total of 11,123 mother-child pairs were included. The mean gestational age at registration was 19.6\u00b17.6 weeks. During pregnancy, 4,115 women (37.0%) experienced sleep disorders. Additionally, 53.7% of the participants had a history of parity, 8.8% worked night shifts, and 0.4% used sleep medications. In the crude models, maternal sleep disorders during pregnancy were associated with all examined allergic diseases in children. After the adjustment for all confounders, the associations remained significant for atopic dermatitis and allergic conjunctivitis\/allergic rhinitis\/hay fever (HR [95% CI], 1.09 [0.97\u20131.23] for bronchial asthma, 1.17 [1.05\u20131.31] for atopic dermatitis, 1.11 [0.98\u20131.26] for food allergy, and 1.25 [1.13\u20131.39] for allergic conjunctivitis\/allergic rhinitis\/hay fever).Conclusion: Maternal sleep disorders during pregnancy were associated with atopic dermatitis as well as allergic conjunctivitis\/allergic rhinitis\/hay fever in children.<\/jats:p>","DOI":"10.3345\/cep.2025.01165","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T06:15:06Z","timestamp":1761113706000},"page":"36-45","update-policy":"https:\/\/doi.org\/10.3345\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal sleep disorders during pregnancy and subsequent risk of allergic diseases in Japanese children: the TMM BirThree Cohort Study"],"prefix":"10.3345","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2209-919X","authenticated-orcid":true,"given":"Ami","family":"Uematsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4871-8455","authenticated-orcid":true,"given":"Masatsugu","family":"Orui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2884-0023","authenticated-orcid":true,"given":"Mami","family":"Ishikuro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2103-4106","authenticated-orcid":true,"given":"Keiko","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-6848","authenticated-orcid":true,"given":"Aoi","family":"Noda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7551-880X","authenticated-orcid":true,"given":"Genki","family":"Shinoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-1674","authenticated-orcid":true,"given":"Taku","family":"Obara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-0911","authenticated-orcid":true,"given":"Shinichi","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1897","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3345\/cep.2025.00423"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2020.1819793"},{"key":"ref3","first-page":"156","volume-title":"The 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