{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:24:57Z","timestamp":1792027497563,"version":"4.4.0"},"reference-count":35,"publisher":"Korean Pediatric Society","issue":"4","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-cep.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pediatr"],"published-print":{"date-parts":[[2026,4,15]]},"abstract":"<jats:p>Background: Multiple perinatal factors influence hemodynamically significant patent ductus arteriosus (HS PDA) in preterm infants.Purpose: This study aimed to identify the risk factors associated with HS PDA in very low birth weight infants (VLBWIs) and determine the predictors of surgical ligation.Methods: This retrospective study included VLBWIs born at 23\u201332 weeks\u2019 gestation whose HS PDA properties could be identified using echocardiography. The infants were stratified into 2 groups based on gestational age (23\u201327 and 28\u201332 weeks).Results: Among the 496 included VLBWIs, 171 had no PDA, 90 had non-HS PDA, and 235 had HS PDA. In infants born at 23\u201327 weeks\u2019 gestation, risk factors for HS PDA included low birth weight, the absence of histological chorioamnionitis, and premature rupture of membranes. For VLBWIs born at 28\u201332 weeks\u2019 gestation, HS PDA was associated with lower birth weight, frequent surfactant treatment, and maternal hypertension. Within the HS PDA group, infants with a lower birth weight or who received incomplete antenatal steroid administration had an increased likelihood of requiring surgical ligation, whereas those with a small-for-gestational-age status had a decreased need for surgical ligation.Conclusion: Recognizing these risk factors can aid the development of targeted treatment strategies for HS PDA in VLBWIs, enabling early ligation and potentially reducing the need for surgical management.<\/jats:p>","DOI":"10.3345\/cep.2025.01893","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T23:58:14Z","timestamp":1774396694000},"page":"313-321","update-policy":"https:\/\/doi.org\/10.3345\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Perinatal risk factors for hemodynamically significant patent ductus arteriosus in very low birth weight 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