{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:52:15Z","timestamp":1777949535080,"version":"3.51.4"},"reference-count":29,"publisher":"Korean Pediatric Society","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-cep.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pediatr"],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:p>Background: Impaired renal function (IRF), defined as the rate of decline in serum creatinine levels during the week after birth, frequently affects neonates with moderate or severe hypoxic-ischemic encephalopathy (HIE). However, its clinical relevance in this vulnerable population requires further investigation.Purpose: This study aimed to evaluate the association between IRF and brain injury severity in neonates with HIE.Methods: This retrospective single-center study included neonates treated with therapeutic hypothermia for moderate or severe HIE. A multivariable logistic regression analysis evaluated the association between IRF and the combined outcomes of early death or severe brain injury (ED\/SevereBI).Results: Of the 147 included neonates, 67 (45.6%) had IRF and 32 (22%) had ED\/SevereBI. Those with ED\/SevereBI were more likely to have a lower 5-min Apgar score (median [interquartile range]: 4 [2\u20135] vs. 2 [1\u20133], P&lt;0.01), have a higher initial blood lactate level (mean cord blood lactate level, +34%, P&lt;0.05), be intubated in the delivery room (50% vs. 75%, P=0.01), and have IRF (39% vs. 69%, P&lt;0.01). After the adjustment for neonatal characteristics and perinatal asphyxia parameters, neonates with IRF had a 2- to 3-fold higher odds of ED\/SevereBI than those without IRF (adjusted odds ratio [95% confidence interval]: 2.66 [1.09\u20136.84], P=0.03).Conclusion: In neonates treated with therapeutic hypothermia for HIE, IRF can be used as a marker of adverse outcomes. Further studies are required to evaluate its long-term prognostic value.<\/jats:p>","DOI":"10.3345\/cep.2025.02670","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:56:19Z","timestamp":1777276579000},"page":"437-442","update-policy":"https:\/\/doi.org\/10.3345\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between impaired renal function based on decline in serum creatinine level and brain injury in neonates with hypoxic-ischemic encephalopathy"],"prefix":"10.3345","volume":"69","author":[{"given":"M\u00e9laine","family":"Boget","sequence":"first","affiliation":[{"name":"APHM, Hospital University La Conception, Neonatal Unit, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3596-2192","authenticated-orcid":true,"given":"William","family":"Rozalen","sequence":"additional","affiliation":[{"name":"APHM, Hospital University La Conception, Neonatal Unit, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Fayard","sequence":"additional","affiliation":[{"name":"APHM, Hospital University La Conception, Neonatal Unit, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-4386","authenticated-orcid":true,"given":"Mohamed","family":"Boucekine","sequence":"additional","affiliation":[{"name":"AMU, EA 3279: CEReSS - Health Service Research and Quality of Life Center, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Gillot","sequence":"additional","affiliation":[{"name":"APHM, Hospital University La Conception, Neonatal Unit, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-6734","authenticated-orcid":true,"given":"Isabelle","family":"Grandvuillemin","sequence":"additional","affiliation":[{"name":"APHM, Hospital University La Conception, Neonatal Unit, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3039-2036","authenticated-orcid":true,"given":"Farid","family":"Boubred","sequence":"additional","affiliation":[{"name":"APHM, Hospital University La Conception, Neonatal Unit, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1897","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.3269"},{"key":"ref2","first-page":"31","volume-title":"Hypoxic-ischemic encephalopathy: changing outcomes across the spectrum","author":"Pappas","year":"2023"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.06.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01846-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcps050929"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd003311"},{"key":"ref7","first-page":"184","volume-title":"Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study","author":"Jetton","year":"2017"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.10.002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-019-04406-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.230"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-023-06214-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.136"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3317-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.09.043"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-024-06287-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.reaurg.2010.10.001"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2021.101304"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-301524"},{"key":"ref19","volume-title":"Growth Fenton 2013"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1361831"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-020-04632-1"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9030049"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-024-01937-z"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.140"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2007080901"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04632-1"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.131"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-022-02735-5"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.2174\/1573396314666180813121652"}],"container-title":["Clinical and Experimental Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.e-cep.org\/upload\/pdf\/cep-2025-02670.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.e-cep.org\/journal\/view.php?doi=10.3345\/cep.2025.02670","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.e-cep.org\/upload\/pdf\/cep-2025-02670.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:50:21Z","timestamp":1777855821000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.e-cep.org\/journal\/view.php?doi=10.3345\/cep.2025.02670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"URL":"https:\/\/doi.org\/10.3345\/cep.2025.02670","relation":{},"ISSN":["2713-4148"],"issn-type":[{"value":"2713-4148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]},"assertion":[{"value":"2025-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}