{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:40:30Z","timestamp":1776386430726,"version":"3.51.2"},"reference-count":43,"publisher":"Korean Pediatric Society","issue":"5","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-cep.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pediatr"],"published-print":{"date-parts":[[2020,5,15]]},"abstract":"<jats:p>IgA vasculitis, formerly known as Henoch-Sch\u00f6nlein purpura, is a systemic IgA-mediated vasculitis of the small vessels commonly seen in children. The natural history of IgA vasculitis is generally self-limiting; however, one-third of patients experience symptom recurrence and a refractory course. This systematic review examined the use of dapsone in refractory IgA vasculitis cases. A literature search of PubMed databases retrieved 13 articles published until June 14, 2018. The most common clinical feature was a palpable rash (100% of patients), followed by joint pain (69.2%). Treatment response within 1\u20132 days was observed in 6 of 26 patients (23.1%) versus within 3\u20137 days in 17 patients (65.4%). Relapse after treatment discontinuation was reported in 17 patients (65.4%) but not in 3 patients (11.5 %). Four of the 26 patients (15.4%) reported adverse effects of dapsone including arthralgia (7.7%), rash (7.7%), and dapsone hypersensitivity syndrome (3.8%). Our findings suggest that dapsone may affect refractory IgA vasculitis. Multicenter randomized placebo-controlled trials are necessary to determine the standard dosage of dapsone at initial or tapering of treatment in IgA vasculitis patients and evaluate whether dapsone has a significant benefit versus steroids or other medications.<\/jats:p>","DOI":"10.3345\/kjp.2019.00514","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T05:32:03Z","timestamp":1569303123000},"page":"158-163","update-policy":"https:\/\/doi.org\/10.3345\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Treatment of refractory IgA vasculitis with dapsone: a systematic review"],"prefix":"10.3345","volume":"63","author":[{"given":"Keum Hwa","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hwi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhae","family":"Jun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngheun","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woogyeong","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayeon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeongho","family":"Joo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guhyun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunghee","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kronbichler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Eisenhut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-1820","authenticated-orcid":true,"given":"Jae Il","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1897","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32833af608"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.066035"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/03009740510026841"},{"key":"ref4","first-page":"124653","volume-title":"New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Sch\u00f6nlein purpura)","author":"Heineke","year":"2017"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2013.850028"},{"key":"ref6","first-page":"781","volume-title":"","author":"Shin","year":"2016"},{"key":"ref7","first-page":"639","volume-title":"Chronic recalcitrant Henoch-Schonlein purpura: successful treatment with dapsone","author":"Papandreou","year":"2010"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70100-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.061598"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/014107688307600717"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.126052"},{"key":"ref13","first-page":"220","volume-title":"Dapsone for the treatment of chronic HSP (Henoch-Schonlein)","author":"Bech","year":"2013"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2005.tb00729.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb08907.x"},{"key":"ref16","first-page":"464","volume-title":"Dapsone in Henoch-Sch\u00f6nlein purpura. 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