{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:17:10Z","timestamp":1761513430718,"version":"3.37.3"},"reference-count":40,"publisher":"XMLink","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"funder":[{"name":"Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea","award":["HI10C2020"],"award-info":[{"award-number":["HI10C2020"]}]}],"content-domain":{"domain":["synapse.koreamed.org"],"crossmark-restriction":false},"short-container-title":["J Korean Med Sci"],"published-print":{"date-parts":[[2014]]},"DOI":"10.3346\/jkms.2014.29.3.392","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T10:05:36Z","timestamp":1394100336000},"page":"392","update-policy":"https:\/\/doi.org\/10.3346\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relationship between Tetrahydrobiopterin and Portal Hypertension in Patients with Chronic Liver Disease"],"prefix":"10.3346","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2229-6936","authenticated-orcid":false,"given":"Won Ki","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-3898","authenticated-orcid":false,"given":"Kwang Yong","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6245-2537","authenticated-orcid":false,"given":"Soon Koo","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-2206","authenticated-orcid":false,"given":"Moon Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7955-4211","authenticated-orcid":false,"given":"Mee Yon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-3885","authenticated-orcid":false,"given":"Yoon Ok","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8808-4530","authenticated-orcid":false,"given":"Young Shik","family":"Park","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Inje University College of Medicine, Gimhae, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1859-3425","authenticated-orcid":false,"given":"Jin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Inje University College of Medicine, Busan, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-8331","authenticated-orcid":false,"given":"Gaeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nursing, Keimyung University College of Nursing, Daegu, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-290X","authenticated-orcid":false,"given":"Youn Zoo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5408-8894","authenticated-orcid":false,"given":"Hye Won","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8152-9541","authenticated-orcid":false,"given":"Jin Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5449-0592","authenticated-orcid":false,"given":"Myeong Hun","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5050-570X","authenticated-orcid":false,"given":"Sang Ok","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18617","reference":[{"key":"10.3346\/jkms.2014.29.3.392_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3350\/kjhep.2012.18.1.1","volume":"18","author":"Suk","year":"2012","journal-title":"Korean J Hepatol"},{"key":"10.3346\/jkms.2014.29.3.392_ref2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3350\/cmh.2012.18.4.391","volume":"18","author":"Kim","year":"2012","journal-title":"Clin Mol Hepatol"},{"key":"10.3346\/jkms.2014.29.3.392_ref3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3350\/kjhep.2008.14.2.150","volume":"14","author":"Kim","year":"2008","journal-title":"Korean J Hepatol"},{"key":"10.3346\/jkms.2014.29.3.392_ref4","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/hep.510270315","volume":"27","author":"Kaneda","year":"1998","journal-title":"Hepatology"},{"key":"10.3346\/jkms.2014.29.3.392_ref5","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1053\/jhep.2002.31432","volume":"35","author":"Wiest","year":"2002","journal-title":"Hepatology"},{"key":"10.3346\/jkms.2014.29.3.392_ref6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4166\/kjg.2010.56.3.129","volume":"56","author":"Kim","year":"2010","journal-title":"Korean J Gastroenterol"},{"key":"10.3346\/jkms.2014.29.3.392_ref7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3350\/kjhep.2010.16.4.347","volume":"16","author":"Kim","year":"2010","journal-title":"Korean J Hepatol"},{"key":"10.3346\/jkms.2014.29.3.392_ref8","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/hep.510280405","volume":"28","author":"Gupta","year":"1998","journal-title":"Hepatology"},{"key":"10.3346\/jkms.2014.29.3.392_ref9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-5926-2-2","volume":"2","author":"Van De Casteele","year":"2003","journal-title":"Comp Hepatol"},{"key":"10.3346\/jkms.2014.29.3.392_ref10","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1053\/jhep.2003.50004","volume":"37","author":"Graupera","year":"2003","journal-title":"Hepatology"},{"key":"10.3346\/jkms.2014.29.3.392_ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3470001","volume":"347","author":"Th\u00f6ny","year":"2000","journal-title":"Biochem J"},{"key":"10.3346\/jkms.2014.29.3.392_ref12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1042\/BJ20110293","volume":"438","author":"Werner","year":"2011","journal-title":"Biochem J"},{"key":"10.3346\/jkms.2014.29.3.392_ref13","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/iub.1136","volume":"65","author":"Tejero","year":"2013","journal-title":"IUBMB Life"},{"key":"10.3346\/jkms.2014.29.3.392_ref14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/hep.21228","volume":"44","author":"Matei","year":"2006","journal-title":"Hepatology"},{"key":"10.3346\/jkms.2014.29.3.392_ref15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jhep.2008.04.014","volume":"49","author":"Matei","year":"2008","journal-title":"J Hepatol"},{"key":"10.3346\/jkms.2014.29.3.392_ref16","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.jhep.2011.02.012","volume":"55","author":"Kim","year":"2011","journal-title":"J Hepatol"},{"key":"10.3346\/jkms.2014.29.3.392_ref17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/hep.1840200104","volume":"20","year":"1994","journal-title":"Hepatology"},{"key":"10.3346\/jkms.2014.29.3.392_ref18","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1002\/pmic.200800973","volume":"9","author":"Lee","year":"2009","journal-title":"Proteomics"},{"key":"10.3346\/jkms.2014.29.3.392_ref19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1055\/s-2008-1040613","volume":"6","author":"Bosch","year":"1986","journal-title":"Semin Liver Dis"},{"key":"10.3346\/jkms.2014.29.3.392_ref20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/hep.20062","volume":"39","author":"Groszmann","year":"2004","journal-title":"Hepatology"},{"key":"10.3346\/jkms.2014.29.3.392_ref21","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1097\/MEG.0b013e32832a21c1","volume":"21","author":"Kim","year":"2009","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.3346\/jkms.2014.29.3.392_ref22","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1109\/58.996561","volume":"49","author":"Sandrin","year":"2002","journal-title":"IEEE Trans Ultrason Ferroelectr Freq Control"},{"key":"10.3346\/jkms.2014.29.3.392_ref23","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.ultrasmedbio.2003.07.001","volume":"29","author":"Sandrin","year":"2003","journal-title":"Ultrasound Med Biol"},{"key":"10.3346\/jkms.2014.29.3.392_ref24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jhep.2005.05.009","volume":"43","author":"De Franchis","year":"2005","journal-title":"J Hepatol"},{"key":"10.3346\/jkms.2014.29.3.392_ref25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","volume":"44","author":"D'Amico","year":"2006","journal-title":"J Hepatol"},{"key":"10.3346\/jkms.2014.29.3.392_ref26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4166\/kjg.2009.54.3.143","volume":"54","author":"Kim","year":"2009","journal-title":"Korean J Gastroenterol"},{"key":"10.3346\/jkms.2014.29.3.392_ref27","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/hep.1840200538","volume":"20","author":"Groszmann","year":"1994","journal-title":"Hepatology"},{"key":"10.3346\/jkms.2014.29.3.392_ref28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.ATV.0000110785.96039.f6","volume":"24","author":"Alp","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.3346\/jkms.2014.29.3.392_ref29","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1172\/JCI17786","volume":"112","author":"Alp","year":"2003","journal-title":"J Clin Invest"},{"key":"10.3346\/jkms.2014.29.3.392_ref30","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nchembio.557","volume":"7","author":"Chidley","year":"2011","journal-title":"Nat Chem Biol"},{"key":"10.3346\/jkms.2014.29.3.392_ref31","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1126\/science.1232972","volume":"340","author":"Haruki","year":"2013","journal-title":"Science"},{"key":"10.3346\/jkms.2014.29.3.392_ref32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/153537020122600104","volume":"226","author":"Johns","year":"2001","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.3346\/jkms.2014.29.3.392_ref33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev.nu.13.070193.001401","volume":"13","author":"Kaufman","year":"1993","journal-title":"Annu Rev Nutr"},{"key":"10.3346\/jkms.2014.29.3.392_ref34","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1146\/annurev.bi.54.070185.003501","volume":"54","author":"Nichol","year":"1985","journal-title":"Annu Rev Biochem"},{"key":"10.3346\/jkms.2014.29.3.392_ref35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijcard.2010.10.029","volume":"156","author":"Aoki","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.3346\/jkms.2014.29.3.392_ref36","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1476-5381.2010.01196.x","volume":"164","author":"F\u00f6rstermann","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.3346\/jkms.2014.29.3.392_ref37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1074\/jbc.M004392200","volume":"276","author":"Heller","year":"2001","journal-title":"J Biol Chem"},{"key":"10.3346\/jkms.2014.29.3.392_ref38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/molehr\/8.3.271","volume":"8","author":"T\u00f3th","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"10.3346\/jkms.2014.29.3.392_ref39","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2010.03.021","volume":"53","author":"Bosch","year":"2010","journal-title":"J Hepatol"},{"key":"10.3346\/jkms.2014.29.3.392_ref40","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1053\/j.gastro.2003.12.012","volume":"126","author":"Fernandez","year":"2004","journal-title":"Gastroenterology"}],"container-title":["Journal of Korean Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/synapse.koreamed.org\/pdf\/10.3346\/jkms.2014.29.3.392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.3346\/jkms.2014.29.3.392","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2014.29.3.392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T06:10:31Z","timestamp":1589523031000},"score":1,"resource":{"primary":{"URL":"https:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2014.29.3.392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.3346\/jkms.2014.29.3.392","relation":{},"ISSN":["1011-8934","1598-6357"],"issn-type":[{"type":"print","value":"1011-8934"},{"type":"electronic","value":"1598-6357"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.3346\/jkms.2014.29.3.392","URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.3346\/jkms.2014.29.3.392","name":"synapse","label":"Synapse","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"http:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2014.29.3.392","URL":"http:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2014.29.3.392","name":"the_journal","label":"the Journal","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2013-10-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-27","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2014 The Korean Academy of Medical Sciences.","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}