{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:37:11Z","timestamp":1793133431331,"version":"4.5.0"},"reference-count":30,"publisher":"XMLink","issue":"40","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018688","name":"Korea Disease Control and Prevention Agency","doi-asserted-by":"publisher","award":["2019E280500"],"award-info":[{"award-number":["2019E280500"]}],"id":[{"id":"10.13039\/100018688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018688","name":"Korea Disease Control and Prevention Agency","doi-asserted-by":"publisher","award":["2020E280700"],"award-info":[{"award-number":["2020E280700"]}],"id":[{"id":"10.13039\/100018688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018688","name":"Korea Disease Control and Prevention Agency","doi-asserted-by":"publisher","award":["2021-10-026"],"award-info":[{"award-number":["2021-10-026"]}],"id":[{"id":"10.13039\/100018688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jkms.org"],"crossmark-restriction":false},"short-container-title":["J Korean Med Sci"],"DOI":"10.3346\/jkms.2023.38.e313","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T19:51:34Z","timestamp":1695325894000},"update-policy":"https:\/\/doi.org\/10.3346\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Association Between Tachycardia and Mortality in Septic Shock Patients According to Serum Lactate Level: A Nationwide Multicenter Cohort Study"],"prefix":"10.3346","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8551-2472","authenticated-orcid":false,"given":"Soo Jin","family":"Na","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-9634","authenticated-orcid":false,"given":"Dong Kyu","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7004-6985","authenticated-orcid":false,"given":"Sunghoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7697-4272","authenticated-orcid":false,"given":"Yeon Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2737-7695","authenticated-orcid":false,"given":"Sang-Bum","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7710-0240","authenticated-orcid":false,"given":"Mi Hyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4945-5623","authenticated-orcid":false,"given":"Ryoung-Eun","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-6588","authenticated-orcid":false,"given":"Chae-Man","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4822-1772","authenticated-orcid":false,"given":"Kyeongman","family":"Jeon","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Korean Sepsis Alliance (KSA) Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","published-online":{"date-parts":[[2023]]},"reference":[{"issue":"1","key":"10.3346\/jkms.2023.38.e313_ref1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13613-021-00869-7","volume":"11","author":"Carrara","year":"2021","journal-title":"Ann Intensive Care"},{"issue":"8","key":"10.3346\/jkms.2023.38.e313_ref2","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/sj.bjp.0707673","volume":"153","author":"Heusch","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.3346\/jkms.2023.38.e313_ref3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/01.CCM.0000150028.64264.14","volume":"33","author":"Sander","year":"2005","journal-title":"Crit Care Med"},{"issue":"16","key":"10.3346\/jkms.2023.38.e313_ref4","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jama.2013.278477","volume":"310","author":"Morelli","year":"2013","journal-title":"JAMA"},{"issue":"6","key":"10.3346\/jkms.2023.38.e313_ref5","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.chest.2021.01.009","volume":"159","author":"Hasegawa","year":"2021","journal-title":"Chest"},{"issue":"9","key":"10.3346\/jkms.2023.38.e313_ref6","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S2213-2600(20)30037-0","volume":"8","author":"Kakihana","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"7","key":"10.3346\/jkms.2023.38.e313_ref7","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.3390\/jcm9072052","volume":"9","author":"Russell","year":"2020","journal-title":"J Clin Med"},{"issue":"5","key":"10.3346\/jkms.2023.38.e313_ref8","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/SHK.0000000000001907","volume":"57","author":"Na","year":"2022","journal-title":"Shock"},{"issue":"8","key":"10.3346\/jkms.2023.38.e313_ref9","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.3346\/jkms.2023.38.e313_ref10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5005\/jp\/books\/12674_32","volume-title":"Principles of Physiology","author":"Pramanik","year":"2015","edition":"5"},{"issue":"6","key":"10.3346\/jkms.2023.38.e313_ref11","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00134-018-5085-0","volume":"44","author":"Levy","year":"2018","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.3346\/jkms.2023.38.e313_ref12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/biostatistics\/kxh002","volume":"5","author":"Bonetti","year":"2004","journal-title":"Biostatistics"},{"issue":"3","key":"10.3346\/jkms.2023.38.e313_ref13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10557-017-6726-1","volume":"31","author":"Liu","year":"2017","journal-title":"Cardiovasc Drugs Ther"},{"issue":"19","key":"10.3346\/jkms.2023.38.e313_ref14","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1002\/(SICI)1097-0258(19981015)17:19<2265::AID-SIM918>3.0.CO;2-B","volume":"17","author":"D\u2019Agostino","year":"1998","journal-title":"Stat Med"},{"issue":"408","key":"10.3346\/jkms.2023.38.e313_ref15","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1080\/01621459.1989.10478868","volume":"84","author":"Rosenbaum","year":"1989","journal-title":"J Am Stat Assoc"},{"issue":"12","key":"10.3346\/jkms.2023.38.e313_ref16","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.ijsu.2014.07.013","volume":"12","author":"von Elm","year":"2014","journal-title":"Int J Surg"},{"issue":"20","key":"10.3346\/jkms.2023.38.e313_ref17","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1056\/NEJM199305203282008","volume":"328","author":"Parrillo","year":"1993","journal-title":"N Engl J Med"},{"issue":"1","key":"10.3346\/jkms.2023.38.e313_ref18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jcrc.2014.10.006","volume":"30","author":"Ostrowski","year":"2015","journal-title":"J Crit Care"},{"issue":"1-2","key":"10.3346\/jkms.2023.38.e313_ref19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.autneu.2007.10.006","volume":"138","author":"Pancoto","year":"2008","journal-title":"Auton Neurosci"},{"issue":"9","key":"10.3346\/jkms.2023.38.e313_ref20","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s00134-016-4249-z","volume":"42","author":"Andreis","year":"2016","journal-title":"Intensive Care Med"},{"issue":"2","key":"10.3346\/jkms.2023.38.e313_ref21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00392-011-0375-3","volume":"101","author":"Hoke","year":"2012","journal-title":"Clin Res Cardiol"},{"issue":"5","key":"10.3346\/jkms.2023.38.e313_ref22","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1186\/cc12889","volume":"17","author":"Wilson","year":"2013","journal-title":"Crit Care"},{"issue":"9","key":"10.3346\/jkms.2023.38.e313_ref23","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1097\/CCM.0b013e31828a678d","volume":"41","author":"Morelli","year":"2013","journal-title":"Crit Care Med"},{"issue":"10","key":"10.3346\/jkms.2023.38.e313_ref24","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1007\/s00134-016-4351-2","volume":"42","author":"Morelli","year":"2016","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.3346\/jkms.2023.38.e313_ref25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13054-020-03445-w","volume":"25","author":"Levy","year":"2021","journal-title":"Crit Care"},{"issue":"Suppl 3","key":"10.3346\/jkms.2023.38.e313_ref26","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/cc4829","volume":"10","author":"Zanotti Cavazzoni","year":"2006","journal-title":"Crit Care"},{"issue":"9","key":"10.3346\/jkms.2023.38.e313_ref27","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00210-018-1527-z","volume":"391","author":"Yamashita","year":"2018","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"8","key":"10.3346\/jkms.2023.38.e313_ref28","doi-asserted-by":"crossref","first-page":"e630","DOI":"10.1097\/CCM.0000000000003806","volume":"47","author":"Desai","year":"2019","journal-title":"Crit Care Med"},{"issue":"7","key":"10.3346\/jkms.2023.38.e313_ref29","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/eurheartj\/ehr351","volume":"33","author":"Landesberg","year":"2012","journal-title":"Eur Heart J"},{"issue":"3","key":"10.3346\/jkms.2023.38.e313_ref30","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.chest.2020.09.274","volume":"159","author":"Lanspa","year":"2021","journal-title":"Chest"}],"container-title":["Journal of Korean Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jkms.org\/pdf\/10.3346\/jkms.2023.38.e313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2023.38.e313","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2023.38.e313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T21:32:11Z","timestamp":1697405531000},"score":1,"resource":{"primary":{"URL":"https:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2023.38.e313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":30,"journal-issue":{"issue":"40","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.3346\/jkms.2023.38.e313","relation":{},"ISSN":["1011-8934","1598-6357"],"issn-type":[{"value":"1011-8934","type":"print"},{"value":"1598-6357","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"2023-02-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2023 The Korean Academy of Medical Sciences.","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}],"article-number":"e313"}}