{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:42:18Z","timestamp":1782304938218,"version":"3.54.5"},"reference-count":47,"publisher":"XMLink","issue":"33","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008126","name":"Jeju National University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008126","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jkms.org"],"crossmark-restriction":false},"short-container-title":["J Korean Med Sci"],"DOI":"10.3346\/jkms.2025.40.e200","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T19:17:17Z","timestamp":1751570237000},"update-policy":"https:\/\/doi.org\/10.3346\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Greater White Matter Hyperintensities and More Severe Cognitive Dysfunction in Mild Cognitive Impairment With Motoric Cognitive Risk Syndrome"],"prefix":"10.3346","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0396-5284","authenticated-orcid":false,"given":"Joon Hyuk","family":"Park","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Jeju National University School of Medicine, Jeju, Korea."},{"name":"Department of Psychiatry, Jeju National University Hospital, Jeju, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-6122","authenticated-orcid":false,"given":"Hyun Ju","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jeju National University School of Medicine, Jeju, Korea."},{"name":"Department of Psychiatry, Jeju National University Hospital, Jeju, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2892-6392","authenticated-orcid":false,"given":"Suyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jeju National University Hospital, Jeju, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8148-9041","authenticated-orcid":false,"given":"Bong Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jeju National University School of Medicine, Jeju, Korea."},{"name":"Department of Radiology, Jeju National University Hospital, Jeju, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"4","key":"10.3346\/jkms.2025.40.e200_ref1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/gerona\/gls191","volume":"68","author":"Verghese","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.3346\/jkms.2025.40.e200_ref2","first-page":"100162","volume":"8","author":"Marquez","year":"2022","journal-title":"Lancet Reg Health Am"},{"key":"10.3346\/jkms.2025.40.e200_ref3","doi-asserted-by":"crossref","first-page":"103990","DOI":"10.1016\/j.archger.2019.103990","volume":"87","author":"Shim","year":"2020","journal-title":"Arch Gerontol Geriatr"},{"issue":"3","key":"10.3346\/jkms.2025.40.e200_ref4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1365-2796.2004.01380.x","volume":"256","author":"Winblad","year":"2004","journal-title":"J Intern Med"},{"issue":"3","key":"10.3346\/jkms.2025.40.e200_ref5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch Neurol"},{"issue":"8","key":"10.3346\/jkms.2025.40.e200_ref6","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/ene.13331","volume":"24","author":"Sekhon","year":"2017","journal-title":"Eur J Neurol"},{"issue":"1","key":"10.3346\/jkms.2025.40.e200_ref7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12877-020-01992-z","volume":"21","author":"Cheng","year":"2021","journal-title":"BMC Geriatr"},{"issue":"6","key":"10.3346\/jkms.2025.40.e200_ref8","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/ene.15281","volume":"29","author":"Yaqub","year":"2022","journal-title":"Eur J Neurol"},{"issue":"3-4","key":"10.3346\/jkms.2025.40.e200_ref9","first-page":"117","volume":"24","author":"Nagamalla","year":"2024","journal-title":"Neurodegener Dis"},{"issue":"3-4","key":"10.3346\/jkms.2025.40.e200_ref10","first-page":"97","volume":"24","author":"Vazquez","year":"2024","journal-title":"Neurodegener Dis"},{"issue":"6","key":"10.3346\/jkms.2025.40.e200_ref11","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/jcsm.12807","volume":"12","author":"Ogama","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.3346\/jkms.2025.40.e200_ref12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuroimage.2014.05.017","volume":"99","author":"Bolandzadeh","year":"2014","journal-title":"Neuroimage"},{"issue":"2","key":"10.3346\/jkms.2025.40.e200_ref13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00401-017-1717-7","volume":"134","author":"Kapasi","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"2","key":"10.3346\/jkms.2025.40.e200_ref14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000329277","volume":"66","author":"Shim","year":"2011","journal-title":"Eur Neurol"},{"issue":"1","key":"10.3346\/jkms.2025.40.e200_ref15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13195-019-0521-0","volume":"11","author":"Puzo","year":"2019","journal-title":"Alzheimers Res Ther"},{"issue":"2","key":"10.3346\/jkms.2025.40.e200_ref16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3233\/JAD-170573","volume":"63","author":"van den Berg","year":"2018","journal-title":"J Alzheimers Dis"},{"issue":"23","key":"10.3346\/jkms.2025.40.e200_ref17","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1212\/WNL.0000000000000505","volume":"82","author":"Kloppenborg","year":"2014","journal-title":"Neurology"},{"issue":"6","key":"10.3346\/jkms.2025.40.e200_ref18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1159\/000334498","volume":"32","author":"Poggesi","year":"2011","journal-title":"Cerebrovasc Dis"},{"key":"10.3346\/jkms.2025.40.e200_ref19","doi-asserted-by":"crossref","first-page":"1412735","DOI":"10.3389\/fnagi.2024.1412735","volume":"16","author":"Li","year":"2024","journal-title":"Front Aging Neurosci"},{"issue":"9","key":"10.3346\/jkms.2025.40.e200_ref20","doi-asserted-by":"crossref","first-page":"e30007","DOI":"10.1016\/j.heliyon.2024.e30007","volume":"10","author":"Xie","year":"2024","journal-title":"Heliyon (Lond)"},{"issue":"3","key":"10.3346\/jkms.2025.40.e200_ref21","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3233\/JAD-220712","volume":"91","author":"Zh\u00e0o","year":"2023","journal-title":"J Alzheimers Dis"},{"key":"10.3346\/jkms.2025.40.e200_ref22","first-page":"100150","volume":"3","author":"Doi","year":"2022","journal-title":"Cereb Circ Cogn Behav"},{"issue":"3","key":"10.3346\/jkms.2025.40.e200_ref23","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/alz.12412","volume":"18","author":"Gomez","year":"2022","journal-title":"Alzheimers Dement"},{"issue":"2","key":"10.3346\/jkms.2025.40.e200_ref24","first-page":"73","volume":"1","author":"Mergeche","year":"2016","journal-title":"J Neuroimaging Psychiatry Neurol"},{"issue":"3","key":"10.3346\/jkms.2025.40.e200_ref25","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JAD-150523","volume":"50","author":"Wang","year":"2016","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"10.3346\/jkms.2025.40.e200_ref26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/geronb\/57.1.P47","volume":"57","author":"Lee","year":"2002","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"issue":"4","key":"10.3346\/jkms.2025.40.e200_ref27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000297523","volume":"29","author":"Kim","year":"2010","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"6","key":"10.3346\/jkms.2025.40.e200_ref28","first-page":"437","volume":"48","author":"Kim","year":"2009","journal-title":"J Korean Neuropsychiatr Assoc"},{"issue":"3","key":"10.3346\/jkms.2025.40.e200_ref29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jpsychores.2004.01.004","volume":"57","author":"Bae","year":"2004","journal-title":"J Psychosom Res"},{"issue":"5","key":"10.3346\/jkms.2025.40.e200_ref30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"issue":"3","key":"10.3346\/jkms.2025.40.e200_ref31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1001\/archneur.55.3.326","volume":"55","author":"Berg","year":"1998","journal-title":"Arch Neurol"},{"issue":"3","key":"10.3346\/jkms.2025.40.e200_ref32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/archneur.58.3.397","volume":"58","author":"Morris","year":"2001","journal-title":"Arch Neurol"},{"issue":"2","key":"10.3346\/jkms.2025.40.e200_ref33","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1037\/0894-4105.14.2.224","volume":"14","author":"Gunning-Dixon","year":"2000","journal-title":"Neuropsychology"},{"issue":"7","key":"10.3346\/jkms.2025.40.e200_ref34","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S1474-4422(02)00190-4","volume":"1","author":"Rom\u00e1n","year":"2002","journal-title":"Lancet Neurol"},{"issue":"10","key":"10.3346\/jkms.2025.40.e200_ref35","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1001\/archneur.58.10.1654","volume":"58","author":"Tierney","year":"2001","journal-title":"Arch Neurol"},{"issue":"7","key":"10.3346\/jkms.2025.40.e200_ref36","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1590\/0004-282X20130057","volume":"71","author":"Sudo","year":"2013","journal-title":"Arq Neuropsiquiatr"},{"issue":"3","key":"10.3346\/jkms.2025.40.e200_ref37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrneurol.2015.10","volume":"11","author":"Prins","year":"2015","journal-title":"Nat Rev Neurol"},{"issue":"5","key":"10.3346\/jkms.2025.40.e200_ref38","doi-asserted-by":"crossref","first-page":"17m11763","DOI":"10.4088\/JCP.17m11763","volume":"79","author":"Park","year":"2018","journal-title":"J Clin Psychiatry"},{"issue":"3","key":"10.3346\/jkms.2025.40.e200_ref39","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3233\/JAD-210494","volume":"83","author":"Yang","year":"2021","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"10.3346\/jkms.2025.40.e200_ref40","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1038\/s41598-018-20084-y","volume":"8","author":"de Bresser","year":"2018","journal-title":"Sci Rep"},{"key":"10.3346\/jkms.2025.40.e200_ref41","doi-asserted-by":"crossref","first-page":"102607","DOI":"10.1016\/j.nicl.2021.102607","volume":"30","author":"Kim","year":"2021","journal-title":"Neuroimage Clin"},{"key":"10.3346\/jkms.2025.40.e200_ref42","doi-asserted-by":"crossref","first-page":"102042","DOI":"10.1016\/j.arr.2023.102042","volume":"90","author":"Badji","year":"2023","journal-title":"Ageing Res Rev"},{"issue":"1","key":"10.3346\/jkms.2025.40.e200_ref43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.trci.2019.02.001","volume":"5","author":"Alber","year":"2019","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.3346\/jkms.2025.40.e200_ref44","doi-asserted-by":"crossref","first-page":"120011","DOI":"10.1016\/j.jns.2021.120011","volume":"433","author":"Narasimhan","year":"2022","journal-title":"J Neurol Sci"},{"issue":"1","key":"10.3346\/jkms.2025.40.e200_ref45","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/17474930221144911","volume":"18","author":"Markus","year":"2023","journal-title":"Int J Stroke"},{"issue":"2","key":"10.3346\/jkms.2025.40.e200_ref46","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2214\/ajr.149.2.351","volume":"149","author":"Fazekas","year":"1987","journal-title":"AJR Am J Roentgenol"},{"key":"10.3346\/jkms.2025.40.e200_ref47","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jad.2015.04.008","volume":"180","author":"Park","year":"2015","journal-title":"J Affect Disord"}],"container-title":["Journal of Korean Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jkms.org\/pdf\/10.3346\/jkms.2025.40.e200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2025.40.e200","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2025.40.e200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T23:40:41Z","timestamp":1756078841000},"score":1,"resource":{"primary":{"URL":"https:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2025.40.e200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":47,"journal-issue":{"issue":"33","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.3346\/jkms.2025.40.e200","relation":{},"ISSN":["1011-8934","1598-6357"],"issn-type":[{"value":"1011-8934","type":"print"},{"value":"1598-6357","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"2024-11-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2025 The Korean Academy of Medical Sciences.","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}],"article-number":"e200"}}