{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T01:08:47Z","timestamp":1778461727417,"version":"3.51.4"},"reference-count":41,"publisher":"XMLink","issue":"18","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2025IP0046-1"],"award-info":[{"award-number":["2025IP0046-1"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00335644"],"award-info":[{"award-number":["RS-2024-00335644"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jkms.org"],"crossmark-restriction":false},"short-container-title":["J Korean Med Sci"],"DOI":"10.3346\/jkms.2026.41.e137","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:26:35Z","timestamp":1775190395000},"update-policy":"https:\/\/doi.org\/10.3346\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proposal for Modified Alpha Fetoprotein Use in Hepatocellular Carcinoma Surveillance: Analysis of the 2018\u20132020 National Cancer Screening Program"],"prefix":"10.3346","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9527-5853","authenticated-orcid":false,"given":"Shinae","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-5897","authenticated-orcid":false,"given":"Sollip","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."},{"name":"Institute of Digital Healthcare, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-134X","authenticated-orcid":false,"given":"Hyeongsu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Medicine, Konkuk University, Chungju, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9175-6441","authenticated-orcid":false,"given":"Hye Ryun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, National Medical Center, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-5850","authenticated-orcid":false,"given":"Jonggi","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18617","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"3","key":"10.3346\/jkms.2026.41.e137_ref1","first-page":"209","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"10.3346\/jkms.2026.41.e137_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17998\/jlc.2022.11.07","volume":"23","author":"Korean Liver Cancer Association (KLCA) and National Cancer Center (NCC) Korea","year":"2023","journal-title":"J Liver Cancer"},{"issue":"9","key":"10.3346\/jkms.2026.41.e137_ref3","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.amjmed.2017.01.021","volume":"130","author":"Singal","year":"2017","journal-title":"Am J Med"},{"issue":"1","key":"10.3346\/jkms.2026.41.e137_ref4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jhep.2022.01.023","volume":"77","author":"Singal","year":"2022","journal-title":"J Hepatol"},{"issue":"1","key":"10.3346\/jkms.2026.41.e137_ref5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13561-020-00296-7","volume":"10","author":"Wu","year":"2020","journal-title":"Health Econ Rev"},{"issue":"10","key":"10.3346\/jkms.2026.41.e137_ref6","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.14309\/ajg.0000000000000715","volume":"115","author":"Parikh","year":"2020","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.3346\/jkms.2026.41.e137_ref7","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1097\/HEP.0000000000000466","volume":"78","author":"Singal","year":"2023","journal-title":"Hepatology"},{"issue":"4","key":"10.3346\/jkms.2026.41.e137_ref8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12072-017-9799-9","volume":"11","author":"Omata","year":"2017","journal-title":"Hepatol Int"},{"issue":"1","key":"10.3346\/jkms.2026.41.e137_ref9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","volume":"69","author":"Galle","year":"2018","journal-title":"J Hepatol"},{"key":"10.3346\/jkms.2026.41.e137_ref10","unstructured":"Ministry of Health and Welfare (KR). Cancer Screening Implementation Guidelines. Updated 2024. Accessed July 9, 2025.  https:\/\/www.law.go.kr\/admRulLsInfoP.do?chrClsCd=&admRulSeq=2100000252092"},{"issue":"1","key":"10.3346\/jkms.2026.41.e137_ref11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.47429\/lmo.2025.15.1.84","volume":"15","author":"Kim","year":"2025","journal-title":"Lab Med Online"},{"issue":"2","key":"10.3346\/jkms.2026.41.e137_ref12","doi-asserted-by":"crossref","first-page":"e0228857","DOI":"10.1371\/journal.pone.0228857","volume":"15","author":"Zhang","year":"2020","journal-title":"PLoS One"},{"key":"10.3346\/jkms.2026.41.e137_ref13","unstructured":"Ministry of Health and Welfare (KR). National Cancer Screening Program. Updated 2025. Accessed December 2, 2024.  https:\/\/www.mohw.go.kr\/menu.es?mid=a10703010300"},{"key":"10.3346\/jkms.2026.41.e137_ref14","unstructured":"National Health Service (UK). NHS screening. Updated 2024. Accessed December 2, 2024.  https:\/\/www.nhs.uk\/conditions\/nhs-screening\/"},{"issue":"6","key":"10.3346\/jkms.2026.41.e137_ref15","doi-asserted-by":"crossref","first-page":"djv436","DOI":"10.1093\/jnci\/djv436","volume":"108","author":"Caverly","year":"2016","journal-title":"J Natl Cancer Inst"},{"key":"10.3346\/jkms.2026.41.e137_ref16","unstructured":"The U.S. Department of Health & Human Services. Viral Hepatitis National Strategic Plan. Updated 2020. Accessed December 2, 2024.  https:\/\/www.hhs.gov\/hepatitis\/viral-hepatitis-national-strategic-plan\/index.html"},{"issue":"5","key":"10.3346\/jkms.2026.41.e137_ref17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.35772\/ghm.2021.01063","volume":"3","author":"Takeuchi","year":"2021","journal-title":"Glob Health Med"},{"key":"10.3346\/jkms.2026.41.e137_ref18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2147\/JHC.S159581","volume":"6","author":"Geh","year":"2019","journal-title":"J Hepatocell Carcinoma"},{"issue":"4","key":"10.3346\/jkms.2026.41.e137_ref19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11901-019-00488-8","volume":"18","author":"Petrasek","year":"2019","journal-title":"Curr Hepatol Rep"},{"issue":"4","key":"10.3346\/jkms.2026.41.e137_ref20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4285\/jkstn.2019.33.4.83","volume":"33","author":"Cho","year":"2019","journal-title":"Korean J Transplant"},{"issue":"7","key":"10.3346\/jkms.2026.41.e137_ref21","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3348\/kjr.2019.0140","volume":"20","author":"Korean Liver Cancer Association (KLCA) and National Cancer Center (NCC), Goyang, Korea","year":"2019","journal-title":"Korean J Radiol"},{"issue":"4","key":"10.3346\/jkms.2026.41.e137_ref22","first-page":"CD013346","volume":"4","author":"Colli","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.3346\/jkms.2026.41.e137_ref23","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/hep.24545","volume":"54","author":"Trinchet","year":"2010","journal-title":"Hepatology"},{"issue":"5","key":"10.3346\/jkms.2026.41.e137_ref24","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1158\/1055-9965.EPI-11-1005","volume":"21","author":"Singal","year":"2012","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"4","key":"10.3346\/jkms.2026.41.e137_ref25","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1001\/jamaoncol.2016.3147","volume":"3","author":"Kim","year":"2017","journal-title":"JAMA Oncol"},{"issue":"4","key":"10.3346\/jkms.2026.41.e137_ref26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3350\/cmh.2022.0294","volume":"28","author":"Korean Liver Cancer Association (KLCA) and National Cancer Center (NCC) Korea","year":"2022","journal-title":"Clin Mol Hepatol"},{"issue":"12","key":"10.3346\/jkms.2026.41.e137_ref27","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3348\/kjr.2022.0822","volume":"23","author":"Korean Liver Cancer Association (KLCA) and National Cancer Center (NCC) Korea","year":"2022","journal-title":"Korean J Radiol"},{"issue":"4","key":"10.3346\/jkms.2026.41.e137_ref28","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cgh.2012.11.029","volume":"11","author":"Lee","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"10.3346\/jkms.2026.41.e137_ref29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cgh.2015.07.049","volume":"14","author":"Tayob","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"10.3346\/jkms.2026.41.e137_ref30","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.cgh.2022.08.018","volume":"21","author":"Choi","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"10.3346\/jkms.2026.41.e137_ref31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ijc.32723","volume":"147","author":"Petrick","year":"2020","journal-title":"Int J Cancer"},{"issue":"5","key":"10.3346\/jkms.2026.41.e137_ref32","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1053\/j.gastro.2023.01.033","volume":"164","author":"Toh","year":"2023","journal-title":"Gastroenterology"},{"issue":"6","key":"10.3346\/jkms.2026.41.e137_ref33","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1053\/j.gastro.2011.12.061","volume":"142","author":"El-Serag","year":"2012","journal-title":"Gastroenterology"},{"issue":"4","key":"10.3346\/jkms.2026.41.e137_ref34","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1053\/j.gastro.2017.06.012","volume":"153","author":"Kanwal","year":"2017","journal-title":"Gastroenterology"},{"issue":"1","key":"10.3346\/jkms.2026.41.e137_ref35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1542-3565(05)00864-5","volume":"4","author":"Llovet","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"10.3346\/jkms.2026.41.e137_ref36","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1159\/000531016","volume":"41","author":"Quek","year":"2023","journal-title":"Dig Dis"},{"issue":"5","key":"10.3346\/jkms.2026.41.e137_ref37","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3343\/alm.2023.43.5.425","volume":"43","author":"Cho","year":"2023","journal-title":"Ann Lab Med"},{"issue":"6","key":"10.3346\/jkms.2026.41.e137_ref38","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3343\/alm.2024.0082","volume":"44","author":"Kim","year":"2024","journal-title":"Ann Lab Med"},{"issue":"6","key":"10.3346\/jkms.2026.41.e137_ref39","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1053\/j.gastro.2018.01.064","volume":"154","author":"Tzartzeva","year":"2018","journal-title":"Gastroenterology"},{"issue":"2","key":"10.3346\/jkms.2026.41.e137_ref40","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cgh.2023.08.003","volume":"22","author":"Daher","year":"2024","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"36","key":"10.3346\/jkms.2026.41.e137_ref41","first-page":"1654","volume":"47","author":"Cedrone","year":"2000","journal-title":"Hepatogastroenterology"}],"container-title":["Journal of Korean Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jkms.org\/pdf\/10.3346\/jkms.2026.41.e137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2026.41.e137","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2026.41.e137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:26:01Z","timestamp":1778459161000},"score":1,"resource":{"primary":{"URL":"https:\/\/jkms.org\/DOIx.php?id=10.3346\/jkms.2026.41.e137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":41,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.3346\/jkms.2026.41.e137","relation":{},"ISSN":["1011-8934","1598-6357"],"issn-type":[{"value":"1011-8934","type":"print"},{"value":"1598-6357","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"2025-05-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2026 The Korean Academy of Medical Sciences.","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}],"article-number":"e137"}}