{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:26:12Z","timestamp":1789057572853,"version":"build-2803163510"},"reference-count":31,"publisher":"Korean Society for Parasitology","issue":"2","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003605","name":"Korea International Cooperation Agency","doi-asserted-by":"publisher","award":["P2014-00076-1"],"award-info":[{"award-number":["P2014-00076-1"]}],"id":[{"id":"10.13039\/501100003605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["parasitol.kr"],"crossmark-restriction":true},"short-container-title":["Korean J Parasitol"],"abstract":"Echinococcosis occurs mainly in areas with heavy livestock farming, such as Central Asia, America, and Australia. <i>Echinococcus granulosus<\/i> sensu lato (s.l.) infection causes echinococcosis in intermediate hosts, such as sheep, cattle, goats, camels, and horses. Numerous cases of echinococcosis occur in Uzbekistan as stock farming is a primary industry. Epidemiological and genetic studies of <i>E. granulosus<\/i> s.l. are very important for mitigating its impact on public health and the economy; however, there are no such studies on <i>E. granulosus<\/i> s.l. in Uzbekistan. In the present study, to determine which genotypes exist and are transmitted, we isolated Echinococcus sp. from definitive hosts (one isolate each from jackal and dog) and intermediate hosts (52 isolates from humans and 6 isolates from sheep) in Uzbekistan and analyzed the isolates by sequencing 2 mitochondrial DNA components (<i>cox1<\/i> and <i>nad1<\/i>). The results showed that all of isolates except one belonged to the <i>E. granulosus<\/i> sensu stricto (s.s.) G1 and G3 genotypes. Phylogenetic analysis based on <i>cox1<\/i> sequences showed that 42 isolates from humans, 6 isolates from sheep, and one isolate from jackal were the G1 genotype, whereas the remaining 8 isolates from human and the one isolate from dog were the G3 genotype. These results suggest that the G1 and G3 genotypes of <i>E. granulosus<\/i> s.s. are predominant in Uzbekistan, and both wild animals and domestic animals are important for maintaining their life cycle. Only one isolate from human sample was confirmed to be <i>E. eqiinus<\/i> (G4 genotype), which is known to be for the first time.<\/jats:p>","DOI":"10.3347\/kjp.2020.58.2.205","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T12:52:14Z","timestamp":1588251134000},"page":"205-210","update-policy":"https:\/\/doi.org\/10.3347\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Phylogenetic Characteristics of Echinococcus granulosus Sensu Lato in Uzbekistan"],"prefix":"10.3347","volume":"58","author":[{"given":"Hye-Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai-Soon","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong Heon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gab-Man","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uktamjon","family":"Suvonkulov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitriy","family":"Kovalenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak Sun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1900","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"ref1","first-page":"1","volume-title":"","year":"2001"},{"key":"ref2","first-page":"74","volume-title":"Studies on the protoscoleces and hooks of Echinococcus granulosus<\/italic> from Libya by scanning electron microscope","author":"Elmajdoub","year":"2014"},{"key":"ref3","first-page":"165","volume-title":"Genetic variants within the genus Echinococcus<\/italic> identified by mitochondrial DNA sequencing","author":"Bowles","year":"1992"},{"key":"ref4","first-page":"969","volume-title":"NADH dehydrogenase 1 gene sequences compared for species and strains of the genus Echinococcus<\/italic>","author":"Bowles","year":"1993"},{"key":"ref5","first-page":"33","volume-title":"Genetic characterization of the Asian Taenia<\/italic>, a newly described taeniid cestode of humans","author":"Bowles","year":"1994"},{"key":"ref6","first-page":"1965","volume-title":"NADH dehydrogenase subunit 1 and cytochrome c oxidase subunit I sequences compared for members of the genus Taenia<\/italic> (Cestoda)","author":"Gasser","year":"1999"},{"key":"ref7","first-page":"85","volume-title":"Taxonomy, phylogeny and molecular epidemiology of Echinococcus multilocularis<\/italic>: from fundamental knowledge to health ecology","author":"Knapp","year":"2015"},{"key":"ref8","first-page":"1017","volume-title":"Phylogenetic systematics of the genus Echinococcus<\/italic> (Cestoda: Taeniidae)","author":"Nakao","year":"2013"},{"key":"ref9","first-page":"37","volume-title":"Molecular epidemiology of cystic echinococcosis","author":"McManus","year":"2003"},{"key":"ref10","first-page":"52","volume-title":"New mitogenome and nuclear evidence on the phylogeny and taxonomy of the highly zoonotic tapeworm Echinococcus granulosus<\/italic> sensu stricto","author":"Kinkar","year":"2017"},{"key":"ref11","first-page":"315","volume-title":"Global distribution of alveolar and cystic echinococcosis","author":"Deplazes","year":"2017"},{"key":"ref12","first-page":"647","volume-title":"Epidemiology of echinococcosis in Kazakhstan: an update","author":"Abdybekova","year":"2015"},{"key":"ref13","first-page":"367","volume-title":"Molecular and morphological characterization of Echinococcus granulosus<\/italic> of human and animal origin in Iran","author":"Harandi","year":"2002"},{"key":"ref14","first-page":"521","volume-title":"Sequence analysis of cox1<\/italic> and nad1<\/italic> genes in Echinococcus granulosus<\/italic> G3 genotype in camels (Camelus dromedarius) from central Iran","author":"Sharbatkhori","year":"2011"},{"key":"ref15","first-page":"383","volume-title":"Infection status of hydatid cysts in humans and sheep in Uzbekistan","author":"Hong","year":"2013"},{"key":"ref16","first-page":"679","volume-title":"Practical Algorisms for PCR-RFLP-Based Genotyping of Echinococcus granulosus<\/italic> sensu lato","author":"Kim","year":"2017"},{"key":"ref17","first-page":"452","volume-title":"Towards a taxonomic revision of the genus Echinococcus<\/italic>","author":"Thompson","year":"2002"},{"key":"ref18","first-page":"145","volume-title":"Variation in Echinococcus<\/italic>: towards a taxonomic revision of the genus","author":"Thompson","year":"1995"},{"key":"ref19","first-page":"1929","volume-title":"Molecular phylogeny based on six nuclear genes suggests that Echinococcus granulosus<\/italic> sensu lato genotypes G6\/G7 and G8\/G10 can be regarded as two distinct species","author":"Laurimae","year":"2018"},{"key":"ref20","first-page":"166","volume-title":"Cystic echinococcosis in South America: systematic review of species and genotypes of Echinococcus granulosus<\/italic> sensu lato in humans and natural domestic hosts","author":"Cucher","year":"2016"},{"key":"ref21","first-page":"1","volume-title":"Advances in Parasitology. Echinococcus<\/italic> and Echinococcosis, Part A. London, UK","author":"Thompson","year":"2017"},{"key":"ref22","first-page":"11","volume-title":"The echinococcoses in Asia: the present situation","author":"Ito","year":"2017"},{"key":"ref23","first-page":"e2262","volume-title":"Molecular characterization of Echinococcus granulosus<\/italic> cysts in north Indian patients: identification of G1, G3, G5 and G6 genotypes","author":"Sharma","year":"2013"},{"key":"ref24","first-page":"377","volume-title":"Genetic variability of Echinococcus granulosus<\/italic> sensu stricto in Europe inferred by mitochondrial DNA sequences","author":"Casulli","year":"2012"},{"key":"ref25","first-page":"729","volume-title":"Global phylogeography and genetic diversity of the zoonotic tapeworm Echinococcus granulosus<\/italic> sensu stricto genotype G1","author":"Kinkar","year":"2018"},{"key":"ref26","first-page":"125","volume-title":"Echinococcosis: a review","author":"Moro","year":"2009"},{"key":"ref27","first-page":"70","volume-title":"Questions about echinococcosis in cattle","author":"Suleimanova","year":"2015"},{"key":"ref28","first-page":"529","volume-title":"Echinococcus granulosus<\/italic> of equine origin from different countries possess uniform morphological characteristics","author":"Kumaratilake","year":"1986"},{"key":"ref29","first-page":"339","volume-title":"Comparative studies on the biology and morphology of Echinococcus granulosus<\/italic> from domestic livestock, moose and reindeer","author":"Sweatman","year":"1963"},{"key":"ref30","first-page":"95","volume-title":"Echinococcus<\/italic> and Taenia<\/italic> spp. from captive mammals in the United Kingdom","author":"Boufana","year":"2012"},{"key":"ref31","first-page":"187","volume-title":"Canine echinococcosis in northern Jordan: increased prevalence and dominance of sheep\/dog strain","author":"Al-Qaoud","year":"2003"}],"container-title":["The Korean Journal of Parasitology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/parasitol.kr\/upload\/pdf\/kjp-58-2-205.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T07:36:15Z","timestamp":1589355375000},"score":1,"resource":{"primary":{"URL":"http:\/\/parasitol.kr\/journal\/view.php?doi=10.3347\/kjp.2020.58.2.205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,4]]}},"URL":"https:\/\/doi.org\/10.3347\/kjp.2020.58.2.205","relation":{},"ISSN":["0023-4001","1738-0006"],"issn-type":[{"value":"0023-4001","type":"print"},{"value":"1738-0006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]},"assertion":[{"value":"2019-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}