{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T11:56:01Z","timestamp":1783857361234,"version":"3.55.0"},"reference-count":17,"publisher":"Korean Society for Parasitology","issue":"5","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Directorate of Higher Education of the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia","award":["1\/EI\/KP.PT.PTNBH\/2021"],"award-info":[{"award-number":["1\/EI\/KP.PT.PTNBH\/2021"]}]},{"name":"IPB Higher Education Research Grant"}],"content-domain":{"domain":["parasitol.kr"],"crossmark-restriction":true},"short-container-title":["Korean J Parasitol"],"abstract":"The development of drug resistance is one of the most severe concerns of malaria control because it increases the risk of malaria morbidity and death. A new candidate drug with antiplasmodial activity is urgently needed. This study evaluated the efficacy of different dosages of aqueous extract of <i>Strychnos ligustrina<\/i> combined with dihydroartemisinin and piperaquine phosphate (DHP) against murine <i>Plasmodium berghei<\/i> infection. The BALB\/c mice aged 6-8 weeks were divided into 6 groups, each consisting of 10 mice. The growth inhibition of compounds against <i>P. berghei<\/i> was monitored by calculating the percentage of parasitemia. The results showed that the mice receiving aqueous extract and combination treatment showed growth inhibition of <i>P. berghei<\/i> in 74% and 94%, respectively. <i>S. ligustrina<\/i> extract, which consisted of brucine and strychnine, effectively inhibited the multiplication of <i>P. berghei<\/i>. The treated mice showed improved hematology profiles, body weight, and temperature, as compared to control mice. Co-treatment with <i>S. ligustrina<\/i> extract and DHP revealed significant antimalarial and antipyretic effects. Our results provide prospects for further discovery of antimalarial drugs that may show more successful chemotherapeutic treatment.<\/jats:p>","DOI":"10.3347\/kjp.2022.60.5.339","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:22:51Z","timestamp":1667175771000},"page":"339-344","update-policy":"https:\/\/doi.org\/10.3347\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antimalarial Efficacy of Aqueous Extract of Strychnos ligustrina and Its Combination with Dihydroartemisinin and Piperaquine Phosphate (DHP) against Plasmodium berghei Infection"],"prefix":"10.3347","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6248-9911","authenticated-orcid":true,"given":"Umi","family":"Cahyaningsih","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti","family":"Sa\u2019diah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasrin","family":"Syafii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5377-1384","authenticated-orcid":true,"given":"Rita Kartika","family":"Sari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Jafar","family":"Maring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arifin Budiman","family":"Nugraha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1900","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"ref1","volume-title":"","year":"2020"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-144"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1134\/1.1405220"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3923\/rjmp.2016.403.408"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5658\/wood.2019.47.5.587"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1416"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1992.11812694"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(99)00096-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1529-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.9.2328"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.12.011"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1280473"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1051\/e3sconf\/202015101023"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00377"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.12.045"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X18500015"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/640790"}],"container-title":["The Korean Journal of Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/parasitol.kr\/upload\/pdf\/kjp-60-5-339.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:23:10Z","timestamp":1667175790000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitol.kr\/journal\/view.php?doi=10.3347\/kjp.2022.60.5.339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,10]]}},"URL":"https:\/\/doi.org\/10.3347\/kjp.2022.60.5.339","relation":{},"ISSN":["0023-4001","1738-0006"],"issn-type":[{"value":"0023-4001","type":"print"},{"value":"1738-0006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,21]]},"assertion":[{"value":"2022-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}