{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:22:08Z","timestamp":1774682528766,"version":"3.50.1"},"reference-count":13,"publisher":"Korean Society for Parasitology","issue":"6","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","award":["800-20200549"],"award-info":[{"award-number":["800-20200549"]}],"id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["parasitol.kr"],"crossmark-restriction":true},"short-container-title":["Korean J Parasitol"],"abstract":"<jats:p>Antimalarial drugs play an important role in the control and treatment of malaria, a deadly disease caused by the protozoan parasite Plasmodium spp. The development of novel antimalarial agents effective against drug-resistant malarial parasites is urgently needed. The novel derivatives, SKM13-MeO and SKM13-F, were designed based on an SKM13 template by replacing the phenyl group with electron-donating (-OMe) or electron-withdrawing groups (-F), respectively, to reverse the electron density. A colorimetric assay was used to quantify cytotoxicity, and in vitro inhibition assays were performed on 3 different blood stages (ring, trophozoite, and schizonts) of P. falciparum 3D7 and the ring\/mixed stage of D6 strain after synchronization. The in vitro cytotoxicity analysis showed that 2 new SKM13 derivatives reduced the cytotoxicity of the SKM13 template. SKM13 maintained the IC&lt;sub&gt;50&lt;\/sub&gt; at the ring and trophozoite stages but not at the schizont stage. The IC&lt;sub&gt;50&lt;\/sub&gt; values for both the trophozoite stage of P. falciparum 3D7 and ring\/mixed stages of D6 demonstrated that 2 SKM13 derivatives had decreased antimalarial efficacy, particularly for the SKM13-F derivative. SKM13 may be comparably effective in ring and trophozoite, and electron-donating groups (-OMe) may be better maintain the antimalarial activity than electron-withdrawing groups (-F) in SKM13 modification.<\/jats:p>","DOI":"10.3347\/kjp.2022.60.6.401","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T23:14:55Z","timestamp":1672269295000},"page":"401-407","update-policy":"https:\/\/doi.org\/10.3347\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In Vitro Evaluation of Two Novel Antimalarial Derivatives of SKM13: SKM13-MeO and SKM13-F"],"prefix":"10.3347","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-8198","authenticated-orcid":true,"given":"Thuy-Tien Thi","family":"Trinh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3775-6173","authenticated-orcid":true,"given":"Young-ah","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-6998","authenticated-orcid":true,"given":"Hyelee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7193-9053","authenticated-orcid":true,"given":"Linh Thi Thuy","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5640-0287","authenticated-orcid":true,"given":"Hayoung","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon-Ai","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4916-6442","authenticated-orcid":true,"given":"Hak Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1406-1747","authenticated-orcid":true,"given":"Seon-Ju","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1900","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"ref1","volume-title":""},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S265602"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01881-12"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025619"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-1725-z"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00258-22"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/membranes12040397"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-66"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-014-0110-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc091737"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-12-r177"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2102310118"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60058"}],"container-title":["The Korean Journal of Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/parasitol.kr\/upload\/pdf\/kjp-60-6-401.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T23:15:09Z","timestamp":1672269309000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitol.kr\/journal\/view.php?doi=10.3347\/kjp.2022.60.6.401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,22]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,12]]}},"URL":"https:\/\/doi.org\/10.3347\/kjp.2022.60.6.401","relation":{},"ISSN":["0023-4001","1738-0006"],"issn-type":[{"value":"0023-4001","type":"print"},{"value":"1738-0006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,22]]},"assertion":[{"value":"2022-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}