{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:53:32Z","timestamp":1782514412471,"version":"3.54.5"},"reference-count":26,"publisher":"Korean Society for Parasitology","issue":"2","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["parahostdis.org"],"crossmark-restriction":true},"short-container-title":["Parasites Hosts Dis"],"abstract":"<jats:p>Lampung is a malaria-endemic region in Indonesia with an annual parasite incidence of 0.06 per 1,000 population. The socio-demographic factors, clinical conditions, and artemisinin combination therapy (ACT) types might affect parasite clearance and parasite density. This study aims to investigate factors that influence parasite clearance and parasite density in malaria patients. A retrospective analytic observational and a cross-sectional approach was used to conduct this study. A total of 66 malaria patients were examined to investigate parasite density and clearance, socio-demographic profiles, clinical conditions, and ACT types. To analyze data, univariate, bivariate, and multivariate tests were used. Age (P=0.045; r=0.238) and ACT type (P=0.021; r=0.273) were the only variables that had a significant correlation with parasite clearance. Age (P=0.003; r=0.345) had a significant correlation with parasite density. The most influential factors related to parasite clearance were the ACT type (dihydroartemisinin piperaquine) (P=0.017; odds ratio (OR) 0.109; 95.0% confidence interval (CI), 0.018\u20130.675) and age (P=0.030; OR 0.132; 95.0% CI, 0.021\u20130.823). Age (P=0.046; OR 0.320; 0.105\u20130.978, 95.0% CI) was the most significant variable associated with parasite density.<\/jats:p>","DOI":"10.3347\/phd.22073","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T02:30:38Z","timestamp":1685500238000},"page":"147-153","update-policy":"https:\/\/doi.org\/10.3347\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Determinant of parasite clearance and density on uncomplicated falciparum malaria infections in malaria-endemic area of Lampung Province, Indonesia"],"prefix":"10.3347","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6938-1628","authenticated-orcid":true,"given":"Jhons Fatriyadi","family":"Suwandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1969-5503","authenticated-orcid":true,"given":"Agnes","family":"Kurniawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6128-6976","authenticated-orcid":true,"given":"Lisawati","family":"Susanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1900","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"ref1","volume-title":"","year":"2020"},{"key":"ref2","volume-title":"","year":"2022"},{"key":"ref3","volume-title":"","year":"2022"},{"key":"ref4","volume-title":"","year":"2022"},{"key":"ref5","volume-title":"","year":"2020"},{"key":"ref6","first-page":"238","volume-title":"","year":"2020"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0445-x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0678-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1323-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025569"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1086\/597258"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2011.06.004"},{"key":"ref13","volume-title":"","year":"2008"},{"key":"ref14","volume-title":"Polymorphism of PfMDR1 and PfATP6 genes in <italic>Plasmodium<\/italic> isolates from <italic>Falciparum<\/italic> malaria patients in Pesawaran District","author":"Suwandi","year":"2014"},{"key":"ref15","first-page":"143","volume-title":"Efficacy of artemisinin base combination therapy and genetic diversity of <italic>Plasmodium falciparum<\/italic> from uncomplicated malaria <italic>Falciparum<\/italic> patient in district of Pesawaran, Province of Lampung, Indonesia","author":"Suwandi","year":"2019"},{"key":"ref16","volume-title":"","author":"Sastroasmoro","year":"2011"},{"key":"ref17","volume-title":"","year":"2003"},{"key":"ref18","volume-title":"","author":"Wijayanti","year":"2011"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-1731-1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4103\/0970-258X.291292"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3923\/aje.2017.19.25"},{"key":"ref22","first-page":"871","volume-title":"Study of the K13 gene polymorphisms in <italic>Plasmodium falciparum<\/italic> in Pesawaran, Lampung, Indonesia","author":"Kurniawan","year":"2018"},{"key":"ref23","first-page":"29","volume-title":"Malaria Vector Bioecology of Anopheles sundaicus in Nongsa Subdistrict, Batam City 2008","author":"Ariati","year":"2008"},{"key":"ref24","first-page":"21","volume-title":"Anopheles mosquito behavior in South Lampung Regency, Lampung Province","author":"Suwito","year":"2012"},{"key":"ref25","first-page":"119","volume-title":"The relationship between parasites density with the clinical manifestation on malaria <italic>Plasmodium falciparum<\/italic> and <italic>Plasmodium vivax<\/italic>","author":"Avrina","year":"2011"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2014.03.011"}],"container-title":["Parasites, Hosts and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/parahostdis.org\/upload\/pdf\/PHD-22073.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T04:23:38Z","timestamp":1685507018000},"score":1,"resource":{"primary":{"URL":"https:\/\/parahostdis.org\/journal\/view.php?doi=10.3347\/PHD.22073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,5]]}},"URL":"https:\/\/doi.org\/10.3347\/phd.22073","relation":{},"ISSN":["2982-5164","2982-6799"],"issn-type":[{"value":"2982-5164","type":"print"},{"value":"2982-6799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,23]]},"assertion":[{"value":"2022-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}