{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:56:41Z","timestamp":1790834201921,"version":"4.1.0"},"reference-count":19,"publisher":"Korean Society for Parasitology","issue":"1","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["820\/2563"],"award-info":[{"award-number":["820\/2563"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["parahostdis.org"],"crossmark-restriction":true},"short-container-title":["Parasit Host Dis"],"abstract":"The use of an effective antimalarial drug is the cornerstone of malaria control. However, the development and spread of resistant <i>Plasmodium falciparum<\/i> strains have placed the global eradication of malaria in serious jeopardy. Molecular marker analysis constitutes the hallmark of the monitoring of <i>Plasmodium<\/i> drug-resistance. This study included 96 <i>P. falciparum<\/i> PCR-positive samples from southern Somalia. The <i>P. falciparum chloroquine resistance transporter<\/i> gene had high frequencies of K76T, A220S, Q271E, N326S, and R371I point mutations. The N86Y and Y184F mutant alleles of the <i>P. falciparum multidrug resistance 1<\/i> gene were present in 84.7 and 62.4% of the isolates, respectively. No mutation was found in the <i>P. falciparum Kelch-13<\/i> gene. This study revealed that chloroquine resistance markers are present at high frequencies, while the parasite remains sensitive to artemisinin (ART). The continuous monitoring of ART-resistant markers and in vitro susceptibility testing are strongly recommended to track resistant strains in real time.<\/jats:p>","DOI":"10.3347\/phd.22140","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T18:33:41Z","timestamp":1677522821000},"page":"78-83","update-policy":"https:\/\/doi.org\/10.3347\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Monitoring antimalarial drug-resistance markers in Somalia"],"prefix":"10.3347","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4701-4683","authenticated-orcid":true,"given":"Abdifatah Abdullahi","family":"Jalei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesara","family":"Na-Bangchang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phunuch","family":"Muhamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3720-3878","authenticated-orcid":true,"given":"Wanna","family":"Chaijaroenkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1900","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00051-10"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5897\/AJPP2018.4942"},{"key":"ref3","volume-title":"","year":"2015"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2008.10.009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12847"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nature12876"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2021.06.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200101253440403"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67787-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1147-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204347"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17781-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2004.03.016"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-106"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-2977-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11553"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-264"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/srep08308"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1095-y"}],"container-title":["Parasites, Hosts and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/parahostdis.org\/upload\/pdf\/PHD-22140.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T19:55:53Z","timestamp":1679860553000},"score":1,"resource":{"primary":{"URL":"https:\/\/parahostdis.org\/journal\/view.php?doi=10.3347\/PHD.22140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,22]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,2]]}},"URL":"https:\/\/doi.org\/10.3347\/phd.22140","relation":{},"ISSN":["2982-5164","2982-6799"],"issn-type":[{"value":"2982-5164","type":"print"},{"value":"2982-6799","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,22]]},"assertion":[{"value":"2022-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}