{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:47:21Z","timestamp":1740185241936,"version":"3.37.3"},"reference-count":28,"publisher":"Korean Society for Parasitology","issue":"1","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Shanghai Natural Science Foundation","doi-asserted-by":"crossref","award":["21ZR1469900"],"award-info":[{"award-number":["21ZR1469900"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai","award":["2023\u20132025"],"award-info":[{"award-number":["2023\u20132025"]}]},{"name":"Key Discipline Project","award":["GWVI-11.1-12"],"award-info":[{"award-number":["GWVI-11.1-12"]}]},{"name":"National Parasitic Resources Center","award":["NPRC-2019-194-30"],"award-info":[{"award-number":["NPRC-2019-194-30"]}]},{"name":"Ministry of Science and Technology"}],"content-domain":{"domain":["parahostdis.org"],"crossmark-restriction":true},"short-container-title":["Parasites Hosts Dis"],"abstract":"<jats:p>The intracellular parasite &lt;i&gt;Babesia microti&lt;\/i&gt; is among the most significant species causing human babesiosis and is an emerging threat to human health worldwide. Unravelling the pathogenic molecular mechanisms of babesiosis is crucial in developing new diagnostic and preventive methods. This study assessed how priming with &lt;i&gt;B. microti&lt;\/i&gt; surface antigen 1 (BHSA 1) and seroreactive antigen 5-1-1 (BHSA 5-1-1) mediate protection against &lt;i&gt;B. microti&lt;\/i&gt; infection. The results showed that 500 \u00b5g\/ml rBMSA1 and rBMSA5-1-1 partially inhibited the invasion of &lt;i&gt;B. microti&lt;\/i&gt; in vitro by 42.0 \u00b1 3.0%, and 48.0 \u00b1 2.1%, respectively. Blood smears revealed that peak infection at 7 days post-infection (dpi) was 19.6%, 24.7%, and 46.7% in the rBMSA1, rBmSA5-1-1, compared to the control groups (healthy mice infected with &lt;i&gt;B. microti&lt;\/i&gt; only), respectively. Routine blood tests showed higher white blood cell, red blood cell counts, and haemoglobin levels in the 2 groups (BMSA1 and BMSA5 5-1-1) than in the infection control group at 0\u201328 dpi. Moreover, the 2 groups had higher serum interferon-\u03b3, tumor necrosis factor-\u03b1 and Interleukin-17A levels, and lower IL-10 levels than the infection control group throughout the study. These 2 potential vaccine candidate proteins partially inhibit in vitro and in vivo &lt;i&gt;B. microti&lt;\/i&gt; infection and enhance host immunological response against &lt;i&gt;B. microti&lt;\/i&gt; infection.<\/jats:p>","DOI":"10.3347\/phd.23077","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T05:37:27Z","timestamp":1709185047000},"page":"53-63","update-policy":"https:\/\/doi.org\/10.3347\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The protective effects of BMSA1 and BMSA5-1-1 proteins against Babesia microti infection"],"prefix":"10.3347","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3488-2147","authenticated-orcid":true,"given":"Yu Chun","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun 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Hosts and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/parahostdis.org\/upload\/pdf\/PHD-23077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T05:38:30Z","timestamp":1709185110000},"score":1,"resource":{"primary":{"URL":"https:\/\/parahostdis.org\/journal\/view.php?doi=10.3347\/PHD.23077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2]]}},"URL":"https:\/\/doi.org\/10.3347\/phd.23077","relation":{},"ISSN":["2982-5164","2982-6799"],"issn-type":[{"type":"print","value":"2982-5164"},{"type":"electronic","value":"2982-6799"}],"subject":[],"published":{"date-parts":[[2024,2,23]]},"assertion":[{"value":"2023-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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