{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T23:36:25Z","timestamp":1764113785763,"version":"3.46.0"},"reference-count":20,"publisher":"Korean Society for Parasitology","issue":"4","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018688","name":"Korea Disease Control and Prevention Agency","doi-asserted-by":"crossref","award":["R25TA00530132-00"],"award-info":[{"award-number":["R25TA00530132-00"]}],"id":[{"id":"10.13039\/100018688","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["parahostdis.org"],"crossmark-restriction":true},"short-container-title":["Parasites Hosts Dis"],"abstract":"<jats:p>Balamuthia mandrillaris is a causative agent of granulomatous amebic encephalitis, a rare but often fatal condition. To investigate the role of T helper (Th) cell subsets in the immune response against B. mandrillaris, we examined 3 mouse strains with distinct immunological profiles: C57BL\/6 (Th1-dominant), BALB\/c (Th2-dominant), and ICR (balanced Th1\/Th2). Mice were infected intranasally with 1\u00d7105 amoebae. Body weight and neurologic symtoms were monitored weekly, and cytokine expression was assessed biweekly over 6 weeks. Minimal weight loss and no mortality were observed in C57BL\/6 mice, whereas BALB\/c and ICR mice exhibited significant early and delayed mortality, respectively. Interleukin-17A expression was notably elevated in C57BL\/6 mice compared with the other strains. These findings indicate that a robust Th17 response, particularly interleukin-17A production, is a critical component of the host defense against B. mandrillaris infection.<\/jats:p>","DOI":"10.3347\/phd.25066","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T23:32:42Z","timestamp":1764113562000},"page":"371-377","update-policy":"https:\/\/doi.org\/10.3347\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Strain-dependent immune responses reveal a critical role of IL-17A in defense against Balamuthia mandrillaris"],"prefix":"10.3347","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6179-3701","authenticated-orcid":true,"given":"Yu Jin","family":"Jeong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9722-870X","authenticated-orcid":true,"given":"Dong 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