{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:55:33Z","timestamp":1791608133306,"version":"4.3.4"},"reference-count":40,"publisher":"XMLink","issue":"7","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1D1A1B07046419"],"award-info":[{"award-number":["NRF-2018R1D1A1B07046419"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["synapse.koreamed.org"],"crossmark-restriction":false},"short-container-title":["Yonsei Med J"],"published-print":{"date-parts":[[2019]]},"DOI":"10.3349\/ymj.2019.60.7.667","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T08:29:40Z","timestamp":1561537780000},"page":"667","update-policy":"https:\/\/doi.org\/10.3349\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Poorly-Controlled Type 1 Diabetes Mellitus Impairs LH-LHCGR Signaling in the Ovaries and Decreases Female Fertility in Mice"],"prefix":"10.3349","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6801-7149","authenticated-orcid":false,"given":"Jaewang","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biomedical Laboratory Science, College of Health Science, Eulji University, Seongnam, Korea."},{"name":"Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-8918","authenticated-orcid":false,"given":"Hoi Chang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1013-6852","authenticated-orcid":false,"given":"So-Youn","family":"Kim","sequence":"additional","affiliation":[{"name":"Olson Center for Women's Health, Department of Obstetrics and Gynecology, and Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-0944","authenticated-orcid":false,"given":"Geum Joon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA."},{"name":"Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1197-3399","authenticated-orcid":false,"given":"Teresa K.","family":"Woodruff","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","reference":[{"key":"10.3349\/ymj.2019.60.7.667_ref1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/humupd\/dms024","volume":"18","author":"Codner","year":"2012","journal-title":"Hum Reprod Update"},{"key":"10.3349\/ymj.2019.60.7.667_ref2","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.3389\/fimmu.2017.01898","volume":"8","author":"Clark","year":"2017","journal-title":"Front Immunol"},{"key":"10.3349\/ymj.2019.60.7.667_ref3","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/1753-0407.12031","volume":"5","author":"Gerard-Gonzalez","year":"2013","journal-title":"J Diabetes"},{"key":"10.3349\/ymj.2019.60.7.667_ref4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1055\/s-0035-1571196","volume":"34","author":"Abell","year":"2016","journal-title":"Semin Reprod Med"},{"key":"10.3349\/ymj.2019.60.7.667_ref5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.fertnstert.2010.10.041","volume":"95","author":"Codner","year":"2011","journal-title":"Fertil Steril"},{"key":"10.3349\/ymj.2019.60.7.667_ref6","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1210\/en.2004-1472","volume":"146","author":"Chang","year":"2005","journal-title":"Endocrinology"},{"key":"10.3349\/ymj.2019.60.7.667_ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/jrf.0.0860001","volume":"86","author":"Diamond","year":"1989","journal-title":"J Reprod Fertil"},{"key":"10.3349\/ymj.2019.60.7.667_ref8","doi-asserted-by":"crossref","first-page":"E1198","DOI":"10.1152\/ajpendo.00097.2007","volume":"293","author":"Ratchford","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3349\/ymj.2019.60.7.667_ref9","doi-asserted-by":"crossref","first-page":"e15901","DOI":"10.1371\/journal.pone.0015901","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"10.3349\/ymj.2019.60.7.667_ref10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1172\/JCI4431","volume":"103","author":"Wang","year":"1999","journal-title":"J Clin Invest"},{"key":"10.3349\/ymj.2019.60.7.667_ref11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.2040-1124.2010.00075.x","volume":"2","author":"Yamane","year":"2011","journal-title":"J Diabetes Investig"},{"key":"10.3349\/ymj.2019.60.7.667_ref12","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3349\/ymj.2007.48.3.526","volume":"48","author":"Jo","year":"2007","journal-title":"Yonsei Med J"},{"key":"10.3349\/ymj.2019.60.7.667_ref13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3349\/ymj.1986.27.2.121","volume":"27","author":"Lee","year":"1986","journal-title":"Yonsei Med J"},{"key":"10.3349\/ymj.2019.60.7.667_ref14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1258\/la.2010.010090","volume":"45","author":"Deeds","year":"2011","journal-title":"Lab Anim"},{"key":"10.3349\/ymj.2019.60.7.667_ref15","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/bit.22250","volume":"103","author":"Xu","year":"2009","journal-title":"Biotechnol Bioeng"},{"key":"10.3349\/ymj.2019.60.7.667_ref16","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3349\/ymj.2015.56.6.1590","volume":"56","author":"Choi","year":"2015","journal-title":"Yonsei Med J"},{"key":"10.3349\/ymj.2019.60.7.667_ref17","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1167\/iovs.04-1340","volume":"46","author":"Barber","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.3349\/ymj.2019.60.7.667_ref18","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1210\/en.2014-1926","volume":"156","author":"Kim","year":"2015","journal-title":"Endocrinology"},{"key":"10.3349\/ymj.2019.60.7.667_ref19","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3349\/ymj.2012.53.6.1142","volume":"53","author":"Kim","year":"2012","journal-title":"Yonsei Med J"},{"key":"10.3349\/ymj.2019.60.7.667_ref20","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1177\/1933719117737851","volume":"25","author":"Kim","year":"2018","journal-title":"Reprod Sci"},{"key":"10.3349\/ymj.2019.60.7.667_ref21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1095\/biolreprod.111.091124","volume":"85","author":"Mainigi","year":"2011","journal-title":"Biol Reprod"},{"key":"10.3349\/ymj.2019.60.7.667_ref22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1095\/biolreprod.113.115311","volume":"90","author":"Richani","year":"2014","journal-title":"Biol Reprod"},{"key":"10.3349\/ymj.2019.60.7.667_ref23","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1007\/s00125-014-3376-8","volume":"57","author":"Wiebe","year":"2014","journal-title":"Diabetologia"},{"key":"10.3349\/ymj.2019.60.7.667_ref24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1242\/dev.114850","volume":"142","author":"Wu","year":"2015","journal-title":"Development"},{"key":"10.3349\/ymj.2019.60.7.667_ref25","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/molehr\/8.7.619","volume":"8","author":"Gordo","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"10.3349\/ymj.2019.60.7.667_ref26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1095\/biolreprod.115.131862","volume":"94","author":"Sutton-McDowall","year":"2016","journal-title":"Biol Reprod"},{"key":"10.3349\/ymj.2019.60.7.667_ref27","doi-asserted-by":"crossref","first-page":"22772","DOI":"10.1038\/srep22772","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci Rep"},{"key":"10.3349\/ymj.2019.60.7.667_ref28","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1177\/1933719115574342","volume":"22","author":"Lee","year":"2015","journal-title":"Reprod Sci"},{"key":"10.3349\/ymj.2019.60.7.667_ref29","first-page":"53","volume":"40","author":"Chillar\u00f3n","year":"2015","journal-title":"Minerva Endocrinol"},{"key":"10.3349\/ymj.2019.60.7.667_ref30","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.2337\/db11-1527","volume":"61","author":"Schoeller","year":"2012","journal-title":"Diabetes"},{"key":"10.3349\/ymj.2019.60.7.667_ref31","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1210\/en.2014-1119","volume":"155","author":"Schoeller","year":"2014","journal-title":"Endocrinology"},{"key":"10.3349\/ymj.2019.60.7.667_ref32","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1095\/biolreprod20.3.552","volume":"20","author":"Johnson","year":"1979","journal-title":"Biol Reprod"},{"key":"10.3349\/ymj.2019.60.7.667_ref33","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1210\/en.2011-1815","volume":"153","author":"Wang","year":"2012","journal-title":"Endocrinology"},{"key":"10.3349\/ymj.2019.60.7.667_ref34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.mito.2010.03.002","volume":"10","author":"Wang","year":"2010","journal-title":"Mitochondrion"},{"key":"10.3349\/ymj.2019.60.7.667_ref35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1083\/jcb.201112094","volume":"197","author":"Burkart","year":"2012","journal-title":"J Cell Biol"},{"key":"10.3349\/ymj.2019.60.7.667_ref36","doi-asserted-by":"crossref","first-page":"e1006580","DOI":"10.1371\/journal.pgen.1006580","volume":"13","author":"Xiong","year":"2017","journal-title":"PLoS Genet"},{"key":"10.3349\/ymj.2019.60.7.667_ref37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1095\/biolreprod.109.080887","volume":"83","author":"Wai","year":"2010","journal-title":"Biol Reprod"},{"key":"10.3349\/ymj.2019.60.7.667_ref38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1477-7827-11-31","volume":"11","author":"Zhang","year":"2013","journal-title":"Reprod Biol Endocrinol"},{"key":"10.3349\/ymj.2019.60.7.667_ref39","first-page":"E38","volume":"275","author":"Moley","year":"1998","journal-title":"Am J Physiol"},{"key":"10.3349\/ymj.2019.60.7.667_ref40","doi-asserted-by":"crossref","first-page":"E226","DOI":"10.1152\/ajpendo.00046.2002","volume":"283","author":"Chi","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"}],"container-title":["Yonsei Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/synapse.koreamed.org\/pdf\/10.3349\/ymj.2019.60.7.667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.3349\/ymj.2019.60.7.667","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eymj.org\/DOIx.php?id=10.3349\/ymj.2019.60.7.667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T07:53:10Z","timestamp":1589529190000},"score":1,"resource":{"primary":{"URL":"https:\/\/eymj.org\/DOIx.php?id=10.3349\/ymj.2019.60.7.667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.3349\/ymj.2019.60.7.667","relation":{},"ISSN":["0513-5796","1976-2437"],"issn-type":[{"value":"0513-5796","type":"print"},{"value":"1976-2437","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.3349\/ymj.2019.60.7.667","URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.3349\/ymj.2019.60.7.667","name":"synapse","label":"Synapse","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"https:\/\/www.eymj.org\/DOIx.php?id=10.3349\/ymj.2019.60.7.667","URL":"https:\/\/www.eymj.org\/DOIx.php?id=10.3349\/ymj.2019.60.7.667","name":"the_journal","label":"the Journal","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2019-02-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-23","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-24","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 Copyright: Yonsei University College of Medicine 2019","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}