{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:03:33Z","timestamp":1790298213143,"version":"4.1.0"},"reference-count":32,"publisher":"The Korean Association for the Study of the Liver","issue":"1","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-cmh.org"],"crossmark-restriction":true},"short-container-title":["Clin Mol Hepatol"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:p>Background\/Aims: Liver cirrhosis is an important cause of morbidity and mortality globally. Every episode of decompensation and hospitalization reduces survival. We studied the clinical profile and long-term outcomes comparing alcohol-related cirrhosis (ALC) and non-ALC.&lt;br\/&gt;Methods: Cirrhosis patients at index hospitalisation (from January 2010 to June 2017), with \u22651 year follow-up were included.&lt;br\/&gt;Results: Five thousand and one hundred thirty-eight cirrhosis patients (age, 49.8\u00b114.6 years; male, 79.5%; alcohol, 39.5%; Child-A:B:C, 11.7%:41.6%:46.8%) from their index hospitalization were analysed. The median time from diagnosis of cirrhosis to index hospitalization was 2 years (0.2\u201310). One thousand and seven hundred seven patients (33.2%) died within a year; 1,248 (24.3%) during index hospitalization. 59.5% (2,316\/3,890) of the survivors, required at least one readmission, with additional mortality of 19.8% (459\/2,316). ALC compared to non-ALC were more often (P&lt;0.001) male (97.7% vs. 67.7%), younger (40\u201350 group, 36.2% vs. 20.2%; P&lt;0.001) with higher liver related complications at baseline, (P&lt;0.001 for each), sepsis: 20.3% vs. 14.9%; ascites: 82.2% vs. 65.9%; spontaneous bacterial peritonitis: 21.8% vs. 15.7%; hepatic encephalopathy: 41.0% vs. 25.0%; acute variceal bleeding: 32.0% vs. 23.7%; and acute kidney injury 30.5% vs. 19.6%. ALC patients had higher Child-Pugh (10.6\u00b12.0 vs. 9.0\u00b12.3), model for end-stage liver-disease scores (21.49\u00b18.47 vs. 16.85\u00b17.79), and higher mortality (42.3% vs. 27.3%, P&lt;0.001) compared to non-ALC.&lt;br\/&gt;Conclusions: One-third of cirrhosis patients die in index hospitalization. 60% of the survivors require at least one rehospitalization within a year. ALC patients present with higher morbidity and mortality and at a younger age.<\/jats:p>","DOI":"10.3350\/cmh.2020.0068","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T07:09:46Z","timestamp":1608016186000},"page":"175-185","update-policy":"https:\/\/doi.org\/10.3350\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Alcohol associated liver cirrhotics have higher mortality after index hospitalization: Long-term data of 5,138 patients"],"prefix":"10.3350","volume":"27","author":[{"given":"Priyanka","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saggere Muralikrishna","family":"Shasthry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok 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