{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:26:01Z","timestamp":1791300361869,"version":"4.1.0"},"reference-count":40,"publisher":"The Korean Association for the Study of the Liver","issue":"2","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1C1B5044890"],"award-info":[{"award-number":["2018R1C1B5044890"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A2C4070136"],"award-info":[{"award-number":["2019R1A2C4070136"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1F1A1076282"],"award-info":[{"award-number":["2020R1F1A1076282"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A2C4001401"],"award-info":[{"award-number":["2021R1A2C4001401"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-cmh.org"],"crossmark-restriction":true},"short-container-title":["Clin Mol Hepatol"],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:p>There is some dissatisfaction with the term \u201cnonalcoholic fatty liver disease (NAFLD),\u201d which overemphasizes alcohol and underemphasizes the importance of metabolic risk factors in this disease. Recently, a consensus recommended \u201cmetabolic (dysfunction)-associated fatty liver disease (MAFLD)\u201d as a more appropriate term to describe fatty liver diseases (FLD) associated with metabolic dysfunction. During the definition change from NAFLD to MAFLD, subjects with FLD and metabolic abnormalities, together with other etiologies of liver diseases such as alcohol, virus, or medication who have been excluded from the NAFLD criteria, were added to the MAFLD criteria, while subjects with FLD but without metabolic abnormality, who have been included in the NAFLD criteria, were excluded from the MAFLD criteria. This means that there is an emphasis on the metabolic dysfunction in MAFLD which may underestimate the prognostic value of hepatic steatosis itself, whereas the MAFLD criteria might better identify subjects who are at a higher risk of hepatic or cardiovascular outcomes. However, non-metabolic risk NAFLD subjects who are excluded from the MAFLD criteria are missed from the diagnosis, and their potential risk can be the cause of future diseases. Although huge controversies remain, this review focused on summarizing recent studies that compared the clinical and prognostic characteristics between subjects with NAFLD and MAFLD.<\/jats:p>","DOI":"10.3350\/cmh.2021.0067","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T19:20:45Z","timestamp":1616440845000},"page":"257-269","update-policy":"https:\/\/doi.org\/10.3350\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["From nonalcoholic fatty liver disease to metabolic-associated fatty liver disease: Big wave or ripple?"],"prefix":"10.3350","volume":"27","author":[{"given":"Seong Hee","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soung Won","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Up","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of Korean NAFLD Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1902","reference":[{"key":"ref1","first-page":"283","volume-title":"Nonalcoholic fatty liver disease","author":"Schaffner","year":"1986"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.312"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.052"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0136"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2018.0037"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"ref7","first-page":"1388","volume-title":"EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease","year":"2016"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14251"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.12.016"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.5009\/gnl20218"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14828"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.06.016"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14472"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322572"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.12.022"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154433"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14675"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.603654"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.12.033"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0137"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14548"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.10.046"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245762"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.12454"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2021.1860019"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13857"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30170"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c912"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-018-1571-5"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-019-05340-9"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05700-9"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0000000000000075"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.01.022"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.12.035"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(20)30294-6"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000000981"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31420"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.10.015"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v12.i12.1228"}],"container-title":["Clinical and Molecular Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-cmh.org\/upload\/pdf\/cmh-2021-0067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-cmh.org\/journal\/view.php?doi=10.3350\/cmh.2021.0067","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-cmh.org\/upload\/pdf\/cmh-2021-0067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T02:21:34Z","timestamp":1618280494000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-cmh.org\/journal\/view.php?doi=10.3350\/cmh.2021.0067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"URL":"https:\/\/doi.org\/10.3350\/cmh.2021.0067","relation":{},"ISSN":["2287-2728","2287-285X"],"issn-type":[{"value":"2287-2728","type":"print"},{"value":"2287-285X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"assertion":[{"value":"2021-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-22","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-01","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}