{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:06:39Z","timestamp":1793747199555,"version":"4.6.1"},"reference-count":51,"publisher":"The Korean Association for the Study of the Liver","issue":"1","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-cmh.org"],"crossmark-restriction":true},"short-container-title":["Clin Mol Hepatol"],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:p>Background\/Aims: Maternal and fetal outcomes in pregnant patients with Non-alcoholic fatty liver disease (NAFLD) have been largely unexplored. To determine the level of evidence associated with maternal and fetal outcomes in pregnant women with NAFLD.Methods: We conducted a comprehensive literature search. The studies included pregnant patients with a previous, current or subsequent diagnosis of NAFLD. We used a random-effects model using odds ratios (OR) with 95% confidence intervals (CI).Results: Twenty-two studies, with 13,641 female NAFLD patients were reviewed. The results highlight that NAFLD patients had a statistically significant increased likelihood of baseline diabetes mellitus (OR, 6.00; 95% CI, 2.21\u201316.31; P&lt;0.001; n=7), baseline Hypertension (OR, 3.75; 95% CI, 2.13\u20136.59; P&lt;0.001; n=4), gestational hypertension (OR, 1.83; 95% CI, 1.03\u20133.26; P=0.041; n=2), and pre-eclampsia (OR, 2.43; 95% CI, 1.46\u20134.04; P=0.001; n=3). The odds for a past and current history of gestational diabetes mellitus were OR, 3.78; 95% CI, 2.21\u20136.44; P&lt;0.001; n=5 and OR, 3.23; 95% CI, 1.97\u2013 5.31; P&lt;0.001; n=6, respectively. As for fetal outcomes, pregnant NAFLD patients were significantly more likely to have a premature birth (OR, 2.02; 95% CI, 1.44\u20132.85; P&lt;0.001; n=4), large for gestational age birth (OR, 2.01; 95% CI, 1.72\u20132.37; P&lt;0.001; n=2) or a history of prior miscarriage or abortion (OR, 1.15; 95% CI, 1.02\u20131.30; P=0.02; n=2). Egger\u2019s regression revealed no evidence of publication bias (P&gt;0.05).Conclusions: This meta-analysis provides pooled evidence that NAFLD is associated with a substantial increase in maternal diabetic and hypertensive complications and multiple adverse fetal outcomes. This data is important for clinicians managing these patients before, during and after pregnancy.<\/jats:p>","DOI":"10.3350\/cmh.2021.0205","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T01:29:55Z","timestamp":1631842195000},"page":"52-66","update-policy":"https:\/\/doi.org\/10.3350\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Systematic review with meta-analysis: Non-alcoholic fatty liver disease and the association with pregnancy outcomes"],"prefix":"10.3350","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-2548","authenticated-orcid":true,"given":"Hydar","family":"El Jamaly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy 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