{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:25:18Z","timestamp":1789673118716,"version":"4.0.1"},"reference-count":20,"publisher":"The Korean Association for the Study of the Liver","issue":"1","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Nurturing Clinician Scientist Scheme"},{"name":"SingHealth Duke-NUS Academic Medical Centre"}],"content-domain":{"domain":["e-cmh.org"],"crossmark-restriction":true},"short-container-title":["Clin Mol Hepatol"],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:p>Background\/Aims: The utility of Baveno-VII criteria of clinically significant portal hypertension (CSPH) to predict decompensation in compensated advanced chronic liver disease (cACLD) patient needs validation. We aim to validate the performance of CSPH criteria to predict the risk of decompensation in an international real-world cohort of cACLD patients.Methods: cACLD patients were stratified into three categories (CSPH excluded, grey zone, and CSPH). The risks of decompensation across different CSPH categories were estimated using competing risk regression for clustered data, with death and hepatocellular carcinoma as competing events. The performance of \u201ctreating definite CSPH\u201d strategy to prevent decompensation using non-selective beta-blocker (NSBB) was compared against other strategies in decision curve analysis.Results: One thousand one hundred fifty-nine cACLD patients (36.8% had CSPH) were included; 7.2% experienced decompensation over a median follow-up of 40 months. Non-invasive assessment of CSPH predicts a 5-fold higher risk of liver decompensation in cACLD patients (subdistribution hazard ratio, 5.5; 95% confidence interval, 4.0\u20137.4). \u201cProbable CSPH\u201d is suboptimal to predict decompensation risk in cACLD patients. CSPH exclusion criteria reliably exclude cACLD patients at risk of decompensation, regardless of etiology. Among the grey zone, the decompensation risk was negligible among viral-related cACLD, but was substantially higher among the non-viral cACLD group. Decision curve analysis showed that \u201ctreating definite CSPH\u201d strategy is superior to \u201ctreating all varices\u201d or \u201ctreating probable CSPH\u201d strategy to prevent decompensation using NSBB.Conclusions: Non-invasive assessment of CSPH may stratify decompensation risk and the need for NSBB in cACLD patients.<\/jats:p>","DOI":"10.3350\/cmh.2022.0181","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T22:08:42Z","timestamp":1662415722000},"page":"135-145","update-policy":"https:\/\/doi.org\/10.3350\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Baveno-VII criteria to predict decompensation and initiate non-selective beta-blocker in compensated advanced chronic liver disease patients"],"prefix":"10.3350","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-1183","authenticated-orcid":true,"given":"Yu Jun","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhaojin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilia","family":"Tosetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Degasperi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanchit","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samagra","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Chuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Yiong","family":"Huak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xiaolong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Saraya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Primignani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1902","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-017-9808-z"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.024"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)31875-0"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/978-3-031-08552-9","volume-title":"BavenoVII - renewing consensus in portalhypertension: report of the Baveno VII consensus workshop: personalized care in portal hypertension","author":"de Franchis","year":"2022"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001158"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.11.053"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.025"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000994"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-07277-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxr032"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s41512-019-0064-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.05.021"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15324"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.09.004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28824"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001887"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2029349"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.03.003"},{"key":"ref19","first-page":"636","volume-title":"Green endoscopy network. Green endoscopy: a call for sustainability in the midst of COVID-19","author":"Maurice","year":"2020"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2021.0015"}],"container-title":["Clinical and Molecular Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-cmh.org\/upload\/pdf\/cmh-2022-0181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-cmh.org\/journal\/view.php?doi=10.3350\/cmh.2022.0181","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-cmh.org\/upload\/pdf\/cmh-2022-0181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T19:35:53Z","timestamp":1673811353000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-cmh.org\/journal\/view.php?doi=10.3350\/cmh.2022.0181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"URL":"https:\/\/doi.org\/10.3350\/cmh.2022.0181","relation":{},"ISSN":["2287-2728","2287-285X"],"issn-type":[{"value":"2287-2728","type":"print"},{"value":"2287-285X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,1]]},"assertion":[{"value":"2022-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-05","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-01","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}